التفاصيل البيبلوغرافية
| العنوان: |
Three-Day Blood Glucose Control via a Glucose Modulator of Glycopolymersome: Sugar versus Sugar |
| المؤلفون: |
Yufen Xiao, Jiamin Zhang, Tong Wu, Shuai Chen, Zhixiong Huang, Jianzhong Du |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Pharmacology, Biotechnology, Science Policy, Chemical Sciences not elsewhere classified, phenylboronic acid derivative, pba either randomly, open new avenues, modulating molecule levels, may provide guidance, exhibits excellent long, bgl regulating efficacy, >- acryloyl glucosamine, statistical copolymer structure, reversible sugar substituting, longest effective sugar, acrylamidophenylboronic acid -<, regulate glucose levels, better glucose responsiveness, >- aga )], >- p, molecular structure, pcl -<, glucose modulator, glucose according, stat <, smartly take, regulation time, natural modulators |
| الوصف: |
Natural modulators, such as insulin, play a significant role in modulating molecule levels. Inspired by the role of natural modulators, herein, we propose a glucose modulator that is composed of a glycopolymersome only to regulate glucose levels. This insulin- and drug-free strategy can smartly take in and snap out glucose according to the surrounding blood glucose levels (BGLs) by reversible sugar substituting. The glycopolymersome is self-assembled from a biodegradable glycopolymer that is composed of sugar and phenylboronic acid derivative, poly(ε-caprolactone)- block -poly[(3-acrylamidophenylboronic acid- stat - N -acryloyl glucosamine] [PCL- b -P(AAPBA- stat -AGA)]. It exhibits excellent long-term hypoglycemic effects toward type 1 diabetic mice for at least 3 days upon one shot without observed side effects, which is the longest effective sugar-regulation time for the insulin and drug-free strategy. Most notably, we explored the effect of the molecular structure of the glycopolymers on the BGL regulating efficacy, where the glucosyl moiety was polymerized with PBA either randomly or separately. Block-statistical glycopolymersomes exhibited lower binding energy to glucose, better glucose responsiveness, and prolonged hypoglycemic effect due to the abundant intramolecular and intermolecular dynamic covalent bonds between AAPBA and AGA. Our finding confirmed the importance of a block-statistical copolymer structure and the key role of sugar in regulating BGLs without involving medication, which may provide guidance and open new avenues for design blood glucose regulating materials. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Three-Day_Blood_Glucose_Control_via_a_Glucose_Modulator_of_Glycopolymersome_Sugar_versus_Sugar/25070519Test |
| DOI: |
10.1021/acs.chemmater.3c03140.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.chemmater.3c03140.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.8E612961 |
| قاعدة البيانات: |
BASE |
