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1دورية أكاديمية
المؤلفون: Xinyue Du, Bingxin Gu, Xiao Wang, Xiangwei Wang, Mengjing Ji, Jianping Zhang, Simin He, Xiaoping Xu, Zhongyi Yang, Shaoli Song
مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Cancer, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, various solid malignancies, mice bearing ht, manual radiolabeling procedures, low nanomolar ic, least 3 h, high radiochemical yields, 24 ± 4, 17 ± 6, high target affinity, fetal bovine serum, blocking experiments implied, 68 sup, 177 sup, clinical [< sup, positive fap expression, ex vivo <, ga /< sup, 50 sub, pet imaging procedures, higher tumor uptake, fap tumors showed, [< sup
الإتاحة: https://doi.org/10.1021/acs.molpharmaceut.3c01008.s001Test
https://figshare.com/articles/journal_contribution/Preclinical_Evaluation_and_a_Pilot_Clinical_Positron_Emission_Tomography_Imaging_Study_of_sup_68_sup_Ga_Ga-FAPI-FUSCC-II/24948052Test -
2دورية أكاديمية
المؤلفون: Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni, Stefano Jottini, Attilio Corradi, Micaela Ricca, Elena Rossetti, Federico Armando, Angelo Peli, Anna Ferrari, Giovanni Martinelli, Maria Teresa Scupoli, Carlo Visco, Massimiliano Bonifacio, Alessia Ripamonti, Carlo Gambacorti-Passerini, Antonio Bonati, Roberto Perris, Paolo Lunghi
المساهمون: Mazzera, Laura, Abeltino, Manuela, Lombardi, Guerino, Cantoni, Anna Maria, Jottini, Stefano, Corradi, Attilio, Ricca, Micaela, Rossetti, Elena, Armando, Federico, Peli, Angelo, Ferrari, Anna, Martinelli, Giovanni, Teresa Scupoli, Maria, Visco, Carlo, Bonifacio, Massimiliano, Ripamonti, Alessia, Gambacorti-Passerini, Carlo, Bonati, Antonio, Perris, Roberto, Lunghi, Paolo
مصطلحات موضوعية: Resistance to tyrosine kinase inhibitors (TKIs) remains a clinical challenge in Ph-positive variants of chronic myeloid leukemia. We provide mechanistic insights into a previously undisclosed MEK1/2/BCR::ABL1/BCR/ABL1-driven signaling loop that may determine the efficacy of arsenic trioxide (ATO) in TKI-resistant leukemic patients. We find that activated MEK1/2 assemble into a pentameric complex with BCR::ABL1, BCR and ABL1 to induce phosphorylation of BCR and BCR::ABL1 at Tyr360 and Tyr177, and ABL1, at Thr735 and Tyr412 residues thus provoking loss of BCR’s tumor-suppression functions, enhanced oncogenic activity of BCR::ABL1, cytoplasmic retention of ABL1 and consequently drug resistance. Coherently, pharmacological blockade of MEK1/2 induces dissociation of the pentameric MEK1/2/BCR::ABL1/BCR/ABL1 complex and causes a concurrent BCRY360/Y177, BCR::ABL1Y360/Y177 and cytoplasmic ABL1Y412/T735 dephosphorylation thereby provoking the rescue of the BCR’s anti-oncogenic activities, nuclear accumulation of ABL1 with tumor-suppressive functions and consequently, growth inhibition of the leukemic cells and an ATO sensitization via BCR-MYC and ABL1-p73 signaling axes activation. Additionally, the allosteric activation of nuclear ABL1 was consistently found to enhance the anti-leukemic effects of the MEK1/2 inhibitor Mirdametinib, which when combined with ATO, significantly prolonged the survival of mice bearing BCR::ABL1-T315I-induced leukemia. These findings highlight the therapeutic potential of MEK1/2-inhibitors/ATO combination for the treatment of TKI-resistant leukemia
العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001022147500002; numberofpages:15; journal:LEUKEMIA; https://hdl.handle.net/11381/2953092Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85163592595
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3دورية أكاديمية
المؤلفون: Ying Liang, Quanlin An, Huaxin Song, Yigang Tang, Shujun Xiao, Jiale Wu, Ni Yan, Biao Yu, Xin Cao, Min Lu
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, similar binding mechanism, potential clinical candidate, potent cellular uptake, poor cellular uptake, frequently mutated protein, acglcas significantly extended, targeting ato trials, targeting arsenical, xenograft tumor, targets pml, sulfur atoms, rationally developed, preclinical studies, oral bioavailability, novel arsenical, normal lines, mutated cancers, miraculous success, mice bearing, mediated pathway, maximally 127
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00104.s001Test
https://figshare.com/articles/journal_contribution/AcGlcAs_A_Novel_P53-Targeting_Arsenical_with_Potent_Cellular_Uptake_and_Cancer_Cell_Selectivity/24781865Test -
4دورية أكاديمية
المؤلفون: Longshuai Zhang (1471612), Jiawei Sun (772107), Wenchao Huang (542678), Sanke Zhang (14332218), Xuliang Deng (306023), Weiping Gao (3624878)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Virology, Chemical Sciences not elsewhere classified, tertiary amine ), novel findings demonstrate, mice bearing melanoma, important protein drug, bulky hydrodynamic volume, blood circulation time, acidic tumor microenvironment, enhanced tumor penetration, tumor penetration, unsatisfactory outcomes, triggered bioreduction, solid tumors, situ growth, simultaneously reduces, nonfouling function, n <, mediated transcytosis, interferon alpha, higher bioactivity, great promise
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5دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )
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6دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )
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7دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )
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8دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )
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9دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )
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10دورية أكاديمية
المؤلفون: Ethan Emberley (11642767), Alison Pan (493316), Jason Chen (15937), Rosalyn Dang (11642770), Matt Gross (11642773), Tony Huang (6483005), Weiqun Li (8297628), Andrew MacKinnon (3448271), Devansh Singh (11642776), Natalija Sotirovska (11642779), Susanne M. Steggerda (11642782), Tracy Wang (2454571), Francesco Parlati (1261995)
مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Developmental Biology, Cancer, Hematology, Chemical Sciences not elsewhere classified, results demonstrate potent, renal cell carcinoma, mice bearing caki, either agent alone, dependence strongly correlated, everolimus plus telaglenastat, everolimus via, telaglenastat revealed, telaglenastat resulted, warburg effect, tumor activity, tricarboxylic acid, proliferative effects, phenomenon known, mtor inhibitor, metabolic profiling, metabolic conversion, highly dependent, gls inhibition, gls )