RAAS, ACE2 and COVID-19; a mechanistic review
| العنوان: | RAAS, ACE2 and COVID-19; a mechanistic review |
|---|---|
| المؤلفون: | Ahmed Elshafei, Emad Gamil Khidr, Maher H. Gomaa, Ahmed A. El-Husseiny |
| المصدر: | Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6465-6470 (2021) Saudi Journal of Biological Sciences |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Coronavirus disease 2019 (COVID-19), QH301-705.5, miR-21, microRNA-21, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ACE2, Review, Disease, CVD, cardiovascular disease, Pharmacology, Lung injury, ACE2, angiotensin-converting enzyme 2, TGF-β, transforming growth factor-beta, ACE1, angiotensin-converting enzyme 1, ACEIs, angiotensin-converting enzyme inhibitors, Ang 1-7, angiotensin 1-7, ERK, extracellular signal-regulated kinase, RAAS, renin-angiotensin-aldosterone system, Fibrosis, Angiotensin 1–7, ARBs, angiotensin receptor blockers, Pulmonary fibrosis, Renin–angiotensin system, medicine, AT2R, angiotensin type 2 receptor, ARBs, Biology (General), COVID-19, coronavirus disease 2019, business.industry, AngII, angiotensin II, NLRP3, (NOD, LRR, and pyrin domain-containing protein 3), Angiotensin II, ACEIs, COVID-19, AngI, angiotensin I, medicine.disease, ICU, intensive care unit, AT1R, angiotensin type 1 receptor, AEC-II, alveolar epithelial type II cells, General Agricultural and Biological Sciences, business, MAPK, mitogen-activated protein kinase, hormones, hormone substitutes, and hormone antagonists, Ang 1-9, angiotensin 1-9 |
| الوصف: | The use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in coronavirus disease 2019 (COVID-19) patients has been claimed as associated with the risk of COVID-19 infection and its subsequent morbidities and mortalities. These claims were resulting from the possibility of upregulating the expression of angiotensin-converting enzyme 2 (ACE2), facilitation of SARS-CoV-2 entry, and increasing the susceptibility of infection in such treated cardiovascular patients. ACE2 and renin-angiotensin-aldosterone system (RAAS) products have a critical function in controlling the severity of lung injury, fibrosis, and failure following the initiation of the disease. This review is to clarify the mechanisms beyond the possible deleterious effects of angiotensin II (Ang II), and the potential protective role of angiotensin 1–7 (Ang 1–7) against pulmonary fibrosis, with a subsequent discussion of the latest updates on ACEIs/ARBs use and COVID-19 susceptibility in the light of these mechanisms and biochemical explanation. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5f9b3141b315ed573222f71db5af3Test http://www.sciencedirect.com/science/article/pii/S1319562X2100574XTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....73d5f9b3141b315ed573222f71db5af3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |