المؤلفون: Andreas Hermann, Florian Länger, Reto Eggenschwiler, Tobias Cantz, Jonathan Lukas Lühmann, Christian Felski, Christopher Jahn, Alexandra Haase, Jared Sterneckert, Ulrich Martin, Doris Steinemann, Susanne Petri, Thomas Gschwendtberger

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific reports 11(1), 22154 (2021). doi:10.1038/s41598-021-01689-2

مصطلحات موضوعية: methods [Gene Editing], Computer science, Science, Induced Pluripotent Stem Cells, Computational biology, medicine.disease_cause, Transfection, Prime (order theory), Article, Genome engineering, Cell Line, chemistry.chemical_compound, Superoxide Dismutase-1, Genome editing, medicine, CRISPR, Humans, Gene, Gene Editing, Mutation, Multidisciplinary, fungi, Amyotrophic Lateral Sclerosis, genetics [Superoxide Dismutase-1], metabolism [Induced Pluripotent Stem Cells], genetics [Amyotrophic Lateral Sclerosis], HEK293 Cells, chemistry, Genetic engineering, methods [Transfection], Medicine, CRISPR-Cas Systems, ddc:600, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e40b5c437aa372905f89fb0497dd8a1Test
http://europepmc.org/articles/PMC8589839Test

المؤلفون: Moldt, B., Staunstrup, N. H., Jakobsen, M., Yáñez-Muñoz, R. J., Mikkelsen, J. G.

المصدر: Moldt , B , Staunstrup , N H , Jakobsen , M , Yáñez-Muñoz , R J & Mikkelsen , J G 2008 , ' Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase ' , BMC Biotechnology , vol. 8 , pp. 60 . https://doi.org/10.1186/1472-6750-8-60Test

مصطلحات موضوعية: DNA Nucleotidyltransferases/*metabolism DNA, Circular/*genetics Fungal Proteins/metabolism Genetic Vectors/*genetics Genome, Viral/*genetics Lentivirus/*genetics Mutagenesis, Insertional/*methods Transfection/*methods, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

العلاقة: https://rhul.elsevierpure.com/en/publications/799039a4-fa2c-440e-bcff-31c34b9ce80dTest

الإتاحة: https://doi.org/10.1186/1472-6750-8-60Test
https://rhul.elsevierpure.com/en/publications/799039a4-fa2c-440e-bcff-31c34b9ce80dTest
https://pure.royalholloway.ac.uk/ws/files/5292712/Moldt_BMCBiotech08IDLV_Flp.pdfTest
http://www.ncbi.nlm.nih.gov/pubmed/18691430Test

المؤلفون: Hans Zempel, Eva-Maria Mandelkow, Julia Luedtke

المساهمون: Smet-Nocca, Caroline

المصدر: New York, NY : Springer New York, Methods in Molecular Biology 1523, 335-340 (2017). doi:10.1007/978-1-4939-6598-4_21
Tau Protein / Smet-Nocca, Caroline (Editor) ; New York, NY : Springer New York, 2017, Chapter 21 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-6596-0=978-1-4939-6598-4 ; doi:10.1007/978-1-4939-6598-4
Methods in Molecular Biology ISBN: 9781493965960

مصطلحات موضوعية: 0301 basic medicine, metabolism [Cytoskeleton], Chemistry, metabolism [Microtubules], Neurodegeneration, High density, Endogeny, Transfection, medicine.disease, analysis [tau Proteins], metabolism [tau Proteins], Cell biology, Rats, 03 medical and health sciences, 030104 developmental biology, Microtubule, metabolism [Neurons], ddc:570, medicine, Tubulin polymerization, Animals, methods [Transfection], Neuronal polarity, Cytoskeleton, Cells, Cultured

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe40b7e162d909d44cb181edad76a39Test
https://pub.dzne.de/record/144652Test

المؤلفون: Angelika Schnieke, Dieter Saur, Nathalie Riesen, Ralf Kühn, Antonio Iglesias, Alexander Kind, Wolfgang Wurst, Anna Pertek, Stefan Eser, Claudia Merkl, Markus Sebastian Hardt, Anja Saalfrank

المصدر: PLOS ONE 8(1), e55170 (2013). doi:10.1371/journal.pone.0055170
PLoS ONE 8:e55170 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e55170 (2013)

مصطلحات موضوعية: Proteomics, Cellular differentiation, Genes, myc, Cell Culture Techniques, lcsh:Medicine, Gene Expression, Embryoid body, Protein Engineering, Molecular Cell Biology, lcsh:Science, Induced pluripotent stem cell, Sox2 protein, rat, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, genetics [Cell Dedifferentiation], Cell Differentiation, Animal Models, Transfection, cytology [Induced Pluripotent Stem Cells], Immunohistochemistry, Blotting, Southern, embryonic structures, methods [Transfection], Technology Platforms, Reprogramming, Research Article, Biotechnology, Induced Pluripotent Stem Cells, Genetic Vectors, Kruppel-Like Transcription Factors, Bioengineering, Biology, Cell Line, genetics [SOXB1 Transcription Factors], Kruppel-Like Factor 4, Model Organisms, SOX2, genetics [Octamer Transcription Factor-3], Animals, ddc:610, GKLF protein, Cell potency, Embryoid Bodies, physiology [Embryoid Bodies], genetics [Genes, myc], genetics [Genetic Vectors], SOXB1 Transcription Factors, lcsh:R, genetics [Kruppel-Like Transcription Factors], fungi, Sequence Analysis, DNA, Cell Dedifferentiation, Embryonic stem cell, Molecular biology, Rats, Rat, lcsh:Q, Octamer Transcription Factor-3, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7e50374ba1e6546a2f66dcdefe37d5Test
http://edoc.mdc-berlin.de/14028/1/14028oa.pdfTest

المؤلفون: Thomas Timm, Sarika Garg, Eckhard Mandelkow, Yipeng Wang, Eva-Maria Mandelkow

المصدر: Neurobiology of aging 32(1), 1-14 (2011). doi:10.1016/j.neurobiolaging.2010.09.008

مصطلحات موضوعية: Aging, pharmacology [Enzyme Inhibitors], Cell Count, cytology [Cerebral Cortex], chemistry.chemical_compound, pathology [Alzheimer Disease], Cricetinae, pharmacology [Glutamic Acid], metabolism [Peptides], Phosphorylation, Enzyme Inhibitors, Cerebral Cortex, Neurons, Aged, 80 and over, biology, pharmacology [Calmodulin-Binding Proteins], Chemistry, Calpain, General Neuroscience, Chinese hamster ovary cell, Neurodegeneration, Glutamate receptor, toxicity [Peptide Fragments], amyloid beta-protein (1-42), Biochemistry, metabolism [Neurons], methods [Transfection], Thapsigargin, Alzheimer's disease, metabolism [Alzheimer Disease], Tau protein, Green Fluorescent Proteins, Glutamic Acid, genetics [Mutation], tau Proteins, ADD3 protein, human, Transfection, pharmacology [Calpain], drug effects [tau Proteins], Cricetulus, drug effects [Phosphorylation], Alzheimer Disease, pharmacology [Thapsigargin], In Situ Nick-End Labeling, medicine, Animals, genetics [Green Fluorescent Proteins], Humans, drug effects [Neurons], ddc:610, Aged, Amyloid beta-Peptides, metabolism [Cerebral Cortex], Okadaic acid, medicine.disease, Embryo, Mammalian, Molecular biology, metabolism [tau Proteins], Peptide Fragments, toxicity [Amyloid beta-Peptides], Rats, Molecular Weight, genetics [tau Proteins], pharmacology [Peptides], Mutation, biology.protein, Calmodulin-Binding Proteins, Neurology (clinical), Geriatrics and Gerontology, methods [In Situ Nick-End Labeling], Peptides, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f89a6900a126906d049eec1315db035Test
https://pub.dzne.de/record/136152Test

المؤلفون: Aljoscha Kleinhammer, Wolfgang Wurst, Ralf Kühn

المصدر: Methods 53(4), 430-436 (2011). doi:10.1016/j.ymeth.2010.12.015

مصطلحات موضوعية: RNA, Untranslated, Transcription, Genetic, metabolism [Recombinases], Transgene, Genetic Vectors, Cre recombinase, Mice, Transgenic, Biology, Transfection, General Biochemistry, Genetics and Molecular Biology, Small hairpin RNA, Recombinases, Mice, RNA interference, metabolism [Embryonic Stem Cells], pharmacology [Doxycycline], Gt(ROSA)26Sor non-coding RNA, mouse, Gene silencing, Animals, Humans, RNA, Small Interfering, Molecular Biology, Embryonic Stem Cells, Regulation of gene expression, Gene knockdown, Recombinase-mediated cassette exchange, Proteins, genetics [Proteins], Molecular biology, Phenotype, Gene Expression Regulation, Genes, biosynthesis [RNA, Small Interfering], Doxycycline, ddc:540, methods [Transfection], RNA Interference, Genetic Engineering

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969738c3594802112742dce07035bb50Test
https://pubmed.ncbi.nlm.nih.gov/21184828Test

المؤلفون: Lars Pache, Renate König, Sumit K. Chanda

المصدر: Pache, Lars; König, Renate; & Chanda, Sumit K. (2011). Identifying HIV-1 host cell factors by genome-scale RNAi screening.. Methods (San Diego, Calif.), 53(1), 3-12. UC Office of the President: California HIV/AIDS Research Program. Retrieved from: http://www.escholarship.org/uc/item/4zz719wnTest

مصطلحات موضوعية: Genome-wide association study, HIV Infections, genetics [RNA, Small Interfering], Host-Derived Cellular Factors, Biology, Transfection, Virus Replication, General Biochemistry, Genetics and Molecular Biology, Small hairpin RNA, RNA interference, High-Throughput Screening Assays, Gene silencing, Humans, RNA, Small Interfering, Molecular Biology, Gene, Genetics, Life Sciences, genetics, metabolism [Host-Derived Cellular Factors], HEK293 Cells, Viral replication, Data Interpretation, Statistical, metabolism, virology [HIV Infections], HIV-1, physiology [HIV-1], methods [Transfection], RNA Interference, Genetic screen, Genome-Wide Association Study

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eca95879a7879d182ba7fde98c6f214Test
https://pubmed.ncbi.nlm.nih.gov/20654720Test

المؤلفون: Sven Lammich, Christian Haass, Akio Fukumori, Harald Steiner, Blanca Isabel Pérez-Revuelta, Aya Yamasaki

المصدر: Journal of neurochemistry 112(4), 940-950 (2010). doi:10.1111/j.1471-4159.2009.06510.x

مصطلحات موضوعية: medicine.medical_treatment, Amino Acid Motifs, Biochemistry, Amyloid beta-Protein Precursor, Mice, Protein structure, metabolism [Amyloid beta-Protein Precursor], Cells, Cultured, chemistry.chemical_classification, Mice, Knockout, Alanine, medicine.diagnostic_test, biology, genetics [Presenilin-1], metabolism [Hyaluronan Receptors], Amino acid, Hyaluronan Receptors, genetics [Amyloid beta-Protein Precursor], methods [Transfection], genetics [Hyaluronan Receptors], genetics [Alanine], chemistry [Presenilin-2], Stereochemistry, methods [Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization], Proteolysis, Protein subunit, Glycine, metabolism [Amyloid beta-Peptides], genetics [Mutation], genetics [Presenilin-2], Cleavage (embryo), Transfection, Presenilin, Cellular and Molecular Neuroscience, Presenilin-2, medicine, Presenilin-1, Animals, Humans, Immunoprecipitation, ddc:610, genetics [Glycine], chemistry [Presenilin-1], Protease, Amyloid beta-Peptides, Active site, Embryo, Mammalian, metabolism [Amyloid Precursor Protein Secretases], Protein Structure, Tertiary, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Mutation, biology.protein, Amyloid Precursor Protein Secretases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe207915062443b851f54b28278d6a1Test
https://pubmed.ncbi.nlm.nih.gov/20021564Test

المؤلفون: Garside, Helen, Waters, Charlotte, Berry, Andy, Rice, Lisa, Ardley, Helen C., White, Anne, Robinson, Philip A., Ray, David W.

المصدر: Garside , H , Waters , C , Berry , A , Rice , L , Ardley , H C , White , A , Robinson , P A & Ray , D W 2006 , ' UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation ' , Journal of Endocrinology , vol. 190 , no. 3 , pp. 621-629 . https://doi.org/10.1677/joe.1.06799Test

مصطلحات موضوعية: Animals, COS Cells, Cercopithecus aethiops, Gene Expression, Gene Expression Regulation, Hela Cells, Homeostasis, Humans, Immunoblotting, Immunoprecipitation, pharmacology: Leupeptins, Mutation, metabolism: Proteasome Endopeptidase Complex, genetics: Receptors, Glucocorticoid, methods: Transfection, Two-Hybrid System Techniques, genetics: Ubiquitin-Conjugating Enzymes

الإتاحة: https://doi.org/10.1677/joe.1.06799Test
https://research.manchester.ac.uk/en/publications/795d5c24-704d-4713-b83e-eb794e94eebcTest

المؤلفون: Phillip A. Sharp, Bridget M. Dolan, Kelly A. Foster, Dieter Edbauer, Chi-Fong Wang, Tomoko Tada, Morgan Sheng, Joel R. Neilson, Matthew N. Batterton, Daniel P. Seeburg

المصدر: Neuron 65(3), 373-384 (2010). doi:10.1016/j.neuron.2010.01.005

مصطلحات موضوعية: Untranslated region, Dendritic spine, enhanced green fluorescent protein, Hippocampus, miR-132, Mice, Fragile X Mental Retardation Protein, metabolism [MicroRNAs], physiology [Fragile X Mental Retardation Protein], Fmr1 protein, mouse, genetics [MicroRNAs], Eukaryotic Initiation Factors, Cells, Cultured, Neurons, Mice, Knockout, Gene knockdown, General Neuroscience, Age Factors, MIRN132 microRNA, mouse, Translation (biology), genetics [Eukaryotic Initiation Factors], Argonaute, physiology [Neurons], methods [Transfection], congenital, hereditary, and neonatal diseases and abnormalities, Dendritic Spines, Neuroscience(all), Green Fluorescent Proteins, Biology, Transfection, metabolism [RNA, Messenger], Receptors, N-Methyl-D-Aspartate, Article, genetics [Fragile X Mental Retardation Protein], MOLNEURO, microRNA, genetics [Receptors, N-Methyl-D-Aspartate], Mirn125 microRNA, mouse, Immunoprecipitation, Animals, genetics [Green Fluorescent Proteins], ddc:610, RNA, Messenger, metabolism [Receptors, N-Methyl-D-Aspartate], Analysis of Variance, Embryo, Mammalian, Rats, nervous system diseases, Mice, Inbred C57BL, MicroRNAs, Animals, Newborn, metabolism [Dendritic Spines], nervous system, cytology [Hippocampus], Synapses, Synaptic plasticity, cytology [Neurons], RNA, CELLBIO, metabolism [Eukaryotic Initiation Factors], physiology [Synapses], NR2A NMDA receptor, Neuroscience, methods [Immunoprecipitation]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96d59e2d33be7585acdadb53374e835Test