Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes
| العنوان: | Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes |
|---|---|
| المؤلفون: | Giuseppe De Michele, Andrea Varrone, Paolo Barone, Marta Ianniciello, Caterina Vicidomini, Marco Salvatore, Carmine Mollica, Katia Longo, Maria Teresa Pellecchia, Marina Picillo, Elena Salvatore, Sabina Pappatà, A. Filla |
| المساهمون: | Pellecchia, MARIA TERESA, Barone, Paolo, C., Mollica, Salvatore, Elena, M., Ianniciello, K., Longo, A., Varrone, C., Vicidomini, Picillo, Marina, DE MICHELE, Giuseppe, Filla, Alessandro, Salvatore, Marco, Pappata', Sabina, Pellecchia, Mt, Barone, P, Mollica, C, Ianniciello, M, Longo, K, Varrone, A, Vicidomini, C, Picillo, M, Salvatore, M, Pappatà, S. |
| المصدر: | Movement disorders 24 (2009): 689–696. doi:10.1002/mds.22440 info:cnr-pdr/source/autori:Pellecchia, MT; Barone, P; Mollica, C; Salvatore, E; Ianniciello, M; Longo, K; Varrone, A; Vicidomini, C; Picillo, M; De Michele, G; Filla, A; Salvatore, M; Pappata, S/titolo:Diffusion-Weighted Imaging in Multiple System Atrophy: A Comparison Between Clinical Subtypes/doi:10.1002%2Fmds.22440/rivista:Movement disorders/anno:2009/pagina_da:689/pagina_a:696/intervallo_pagine:689–696/volume:24 |
| بيانات النشر: | Raven Press, [New York, N.Y.] , Stati Uniti d'America, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Cerebellum, Pathology, medicine.medical_specialty, methods, Male, Middle Aged, Multiple System Atrophy, Brain mapping, Severity of Illness Index, Computer-Assisted, Atrophy, stomatognathic system, parasitic diseases, mental disorders, medicine, Middle cerebellar peduncle, Image Processing, Computer-Assisted, Humans, classification/pathology, Severity of Illness Index, Aged, Analysis of Variance, Brain Mapping, medicine.diagnostic_test, Putamen, Magnetic resonance imaging, methods, Female, Humans, Image Processing, Middle Aged, Multiple System Atrophy, medicine.disease, Pons, nervous system diseases, medicine.anatomical_structure, Diffusion Magnetic Resonance Imaging, Neurology, nervous system, Female, Neurology (clinical), Psychology, Aged, Analysis of Variance, Brain Mapping, Diffusion Magnetic Resonance Imaging, Diffusion MRI |
| الوصف: | Multiple system atrophy call be classified into two main types, a Parkinsonian (MSA-P) and a cerebellar (MSA-C) variant based on clinical presentation. We obtained diffusion-weighted magnetic resonance imaging (DWI) in 9 MSA-P and 12 MSA-C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA-P than in MSA-C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA-C than in MSA-P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA-P patients, and in cerebellum and MCP of MSA-C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA-P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA-P and MSA-C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA-P patients and in the cerebellum and MCP in MSA-C patients could serve as quantitative markers for microstructural damage in the course of disease. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3e5c317131c9e03cfed40eb8c5c80aTest http://www.cnr.it/prodotto/i/13986Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fc3e5c317131c9e03cfed40eb8c5c80a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |