المؤلفون: Manoj Kumar, Manasa P Srikanth, Michela Deleidi, Penelope J Hallett, Ole Isacson, Ricardo A Feldman

المصدر: Human molecular genetics 32(11), 1888-1900 (2023). doi:10.1093/hmg/ddad025

مصطلحات موضوعية: Acid Ceramidase, metabolism [Parkinson Disease], Mechanistic Target of Rapamycin Complex 1, genetics [Glucosylceramidase], metabolism [Lysosomes], ddc:570, Genetics, Humans, metabolism [alpha-Synuclein], metabolism [Glucosylceramidase], Molecular Biology, Genetics (clinical), TOR Serine-Threonine Kinases, metabolism [Dopaminergic Neurons], genetics [Mechanistic Target of Rapamycin Complex 1], MTOR Inhibitors, General Medicine, genetics [TOR Serine-Threonine Kinases], genetics [Acid Ceramidase], metabolism [Induced Pluripotent Stem Cells], metabolism [Gaucher Disease], Mutation, genetics [alpha-Synuclein], alpha-Synuclein, Glucosylceramidase, metabolism [Acid Ceramidase]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e623d80d2d569f3311782fe53a2d787Test
https://doi.org/10.1093/hmg/ddad025Test

المؤلفون: Clive N. Svendsen, Helwig M, Nigel T. Maidment, Iris Lindberg, Yucer Nur, Zhan Shu, Di Monte D, Hoa A. Lam, Laperle Alexander

المصدر: Journal of Parkinson's Disease 12(5), 1463-1478 (2022). doi:10.3233/JPD-213053
J Parkinsons Dis

مصطلحات موضوعية: therapy [Parkinson Disease], Parkinson's disease, Tyrosine 3-Monooxygenase, Dopamine, Rodentia, Striatum, Biology, Neuroprotection, Article, Mice, Cellular and Molecular Neuroscience, cytoprotection, proSAAS, medicine, metabolism [Substantia Nigra], Animals, Alpha synuclein, chaperone, ddc:610, metabolism [Dopamine], metabolism [alpha-Synuclein], PCSK1N, metabolism [Rodentia], Tyrosine hydroxylase, Dopaminergic Neurons, Dopaminergic, metabolism [Dopaminergic Neurons], Neurotoxicity, Parkinson Disease, medicine.disease, Rats, metabolism [Tyrosine 3-Monooxygenase], Substantia Nigra, Disease Models, Animal, medicine.anatomical_structure, alpha-Synuclein, Synuclein, Parkinson’s disease, Neuron, Neurology (clinical), dopamine, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cd3ba9f0dfbd58bcf8b93d3bd27c1dTest
https://doi.org/10.3233/jpd-213053Test

المؤلفون: Dimitri Krainc, Aaron M. Earley, Rajeshwar Awatramani, Lena F. Burbulla

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific reports 11(1), 22257 (2021). doi:10.1038/s41598-021-01366-4

مصطلحات موضوعية: Neurogenesis, Cellular differentiation, Science, Induced Pluripotent Stem Cells, Stem-cell differentiation, genetics [Basic Helix-Loop-Helix Transcription Factors], Developmental neurogenesis, Biology, Article, ASCL1 protein, human, Basic Helix-Loop-Helix Transcription Factors, Humans, Gene Regulatory Networks, Induced pluripotent stem cell, Transcription factor, methods [Computational Biology], cytology [Dopaminergic Neurons], Regulation of gene expression, Multidisciplinary, genetics [Cell Differentiation], Dopaminergic Neurons, Gene Expression Profiling, metabolism [Dopaminergic Neurons], Computational Biology, Gene Expression Regulation, Developmental, High-Throughput Nucleotide Sequencing, Cell Differentiation, cytology [Induced Pluripotent Stem Cells], Cell biology, metabolism [Induced Pluripotent Stem Cells], ASCL1, NEUROD1, Neuronal development, Medicine, Stem cell, ddc:600, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8456125706a31a7ab6245db54f126b4Test
https://doaj.org/article/c21875a492da40c9b0c929e0d4c3f82aTest

المؤلفون: Laura Malz, Eva M Szego, Nadine Bernhardt, Angela Rösen-Wolff, Björn H Falkenburger, Hella Luksch

المصدر: eLife 11, e81943 (2022). doi:10.7554/eLife.81943

مصطلحات موضوعية: General Immunology and Microbiology, genetics [Neuroinflammatory Diseases], General Neuroscience, pathology [Dopaminergic Neurons], metabolism [Dopaminergic Neurons], pathology [Neurodegenerative Diseases], neurodegeneration, General Medicine, metabolism [Microglia], General Biochemistry, Genetics and Molecular Biology, neuroinflammation, neuroscience, Mice, metabolism [Neuroinflammatory Diseases], synuclein, nervous system, genetics [Parkinson Disease], inflammasome, parkinson, Neuroinflammatory Diseases, Animals, ddc:600, innate immunity, mouse

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ebd0eda879f38af5d4f9039f24f7b0Test
https://pubmed.ncbi.nlm.nih.gov/36314770Test

المؤلفون: Sonja Blumenstock, Jochen Herms, Carmelo Sgobio, Fanfan Sun, Severin Filser, Jose Medina-Luque, Armando G. Salinas

المصدر: Brain Pathology
Brain pathology 32(2), e13036 (2022). doi:10.1111/bpa.13036

مصطلحات موضوعية: Pathology, medicine.medical_specialty, pathology [Corpus Striatum], Dopamine, metabolism [Parkinson Disease], Nigrostriatal pathway, Biology, Neurotransmission, Pathology and Forensic Medicine, Midbrain, Mice, α-synuclein, medicine, Animals, ddc:610, metabolism [Dopamine], metabolism [alpha-Synuclein], neurotransmission, PFFs, nigrostriatal pathway, General Neuroscience, Dopaminergic Neurons, Dopaminergic, metabolism [Dopaminergic Neurons], Parkinson Disease, Pathophysiology, Corpus Striatum, medicine.anatomical_structure, nervous system, alpha-Synuclein, α synuclein, Neurology (clinical), Neuron, dopamine, spreading, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51edb0cf7cd5166ab5359034bce8f792Test
https://hdl.handle.net/21.11116/0000-0009-988D-D21.11116/0000-0009-988F-BTest

المؤلفون: Rachel M. Wise, Annika Wagener, Urban M. Fietzek, Thomas Klopstock, Eugene V. Mosharov, Fabio A. Zucca, David Sulzer, Luigi Zecca, Lena F. Burbulla

المصدر: Neurobiology of disease 175, 105920 (2022). doi:10.1016/j.nbd.2022.105920

مصطلحات موضوعية: Dopamine, Iron, Parkinson's disease, metabolism [Dopaminergic Neurons], metabolism [Parkinson Disease], Alpha-synuclein, Neurology, metabolism [Brain], ddc:570, Neurodegeneration with Brain Iron Accumulation, metabolism [Substantia Nigra], Humans, metabolism [alpha-Synuclein], metabolism [Dopamine], Neurodegeneration, metabolism [Iron]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af483d3e4c845c3200e9ee282e038fbTest
https://doi.org/10.1016/j.nbd.2022.105920Test

المؤلفون: Marvin Oldrati, Daria Messelodi, Ivana Nikić-Spiegel, Maria-Jose Perez, Cong Yu, Aleksandra Arsić, Thomas Gasser, David C. Schöndorf, Vasiliki Panagiotakopoulou, Dina Ivanyuk, Meike Jakobi, Ruggiero Pio Cassatella, Silvia De Cicco, Michela Deleidi, Wadood Haq, Nicole Schneiderhan-Marra

المساهمون: Panagiotakopoulou V., Ivanyuk D., De Cicco S., Haq W., Arsic A., Yu C., Messelodi D., Oldrati M., Schondorf D.C., Perez M.-J., Cassatella R.P., Jakobi M., Schneiderhan-Marra N., Gasser T., Nikic-Spiegel I., Deleidi M.

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4

مصطلحات موضوعية: 0301 basic medicine, Intravital Microscopy, Glycolysi, THP-1 Cells, Cellular differentiation, NF-KAPPA-B, metabolism [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], General Physics and Astronomy, immunology [Signal Transduction], Diseases, KINASE LRRK2, CYTOSKELETON, Stem cells, SUSCEPTIBILITY, metabolism [Microglia], Microtubules, Induced Pluripotent Stem Cell, NFATC Transcription Factor, Gene Knockout Techniques, 0302 clinical medicine, HEK293 Cell, immunology [Interferon-gamma], genetics [Parkinson Disease], TRANSCRIPTION FACTOR, Induced pluripotent stem cell, lcsh:Science, genetics [Glycolysis], Multidisciplinary, Microglia, Chemistry, IMMUNE-RESPONSES, Neurodegeneration, metabolism [Dopaminergic Neurons], Gene Knockout Technique, NEURODEGENERATION, NFAT, Cell Differentiation, Parkinson Disease, LRRK2, immunology [Microglia], Cell biology, Multidisciplinary Sciences, medicine.anatomical_structure, Science & Technology - Other Topics, metabolism [Interferon-gamma], Cytokines, ddc:500, Signal transduction, Dopaminergic Neuron, Glycolysis, Human, Signal Transduction, Neurite, Science, immunology [Dopaminergic Neurons], metabolism [Microtubules], Immunology, Induced Pluripotent Stem Cells, Primary Cell Culture, Microtubule, OPERATED CA2+ ENTRY, genetics [Signal Transduction], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, General Biochemistry, Genetics and Molecular Biology, CALCIUM, Article, 03 medical and health sciences, Interferon-gamma, immunology [Parkinson Disease], medicine, Humans, Calcium Signaling, Cytokine, Science & Technology, NFATC Transcription Factors, Dopaminergic Neurons, metabolism [Cytokines], General Chemistry, medicine.disease, pathology [Parkinson Disease], nervous system diseases, MODEL, 030104 developmental biology, HEK293 Cells, nervous system, metabolism [NFATC Transcription Factors], Mutation, genetics [Calcium Signaling], genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], lcsh:Q, physiology [Induced Pluripotent Stem Cells], 030217 neurology & neurosurgery, Neuroscience

وصف الملف: Electronic; ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac34786697a3cff0d6b047aa772ef7Test
http://link.springer.com/article/10.1038/s41467-020-18755-4Test

المؤلفون: Anke Van der Perren, Veerle Baekelandt, Björn H. Falkenburger, Lennart Höfs, Chris Van Den Haute, Eva M. Szegö

المصدر: Experimental neurology 347, 113900 (2022). doi:10.1016/j.expneurol.2021.113900

مصطلحات موضوعية: Male, pathology [Dopaminergic Neurons], Parkinson's disease, drug effects [Dopaminergic Neurons], Striatum, physiology [Oxidative Stress], biosynthesis [rab7 GTP-Binding Proteins], medicine.disease_cause, Mice, chemistry.chemical_compound, Rab7, metabolism [Reactive Oxygen Species], Axon, Cells, Cultured, pharmacology [rab7 GTP-Binding Proteins], metabolism [Dopaminergic Neurons], Neurodegeneration, Dopaminergic, Neuroprotection, physiology [DNA Damage], Cell biology, medicine.anatomical_structure, Neurology, drug effects [DNA Damage], alpha-Synuclein, drug effects [Oxidative Stress], Female, Protein aggregation, Neurite, toxicity [alpha-Synuclein], Developmental Neuroscience, medicine, Autophagy, Animals, Humans, ddc:610, biosynthesis [alpha-Synuclein], Rats, Wistar, Alpha-synuclein, Dopaminergic Neurons, rab7 GTP-Binding Proteins, medicine.disease, Rats, Mice, Inbred C57BL, Oxidative Stress, chemistry, Oxidative stress, DNA damage, Reactive Oxygen Species, DNA Damage

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05b397acfc3516ae9446415578af5ecTest

المؤلفون: Yujia Zhao, Yuze Qi, Qingru Li, Huihui Quan, Dan Liu, Hui Zhou

المصدر: Neuroscience letters 771, 136471 (2022). doi:10.1016/j.neulet.2022.136471

مصطلحات موضوعية: Male, Lipopolysaccharides, metabolism [Nerve Growth Factors], metabolism [Parkinson Disease], drug effects [Dopaminergic Neurons], Lipopolysaccharide, metabolism [Microglia], drug effects [Microglia], Connexins, Mice, toxicity [Lipopolysaccharides], Animals, Connexin43, ddc:610, Nerve Growth Factors, therapeutic use [Oligopeptides], Inflammation, Cell Death, General Neuroscience, Dopaminergic Neurons, metabolism [Dopaminergic Neurons], pharmacology [Oligopeptides], Parkinson Disease, pharmacology [Connexins], metabolism [Connexin 43], drug therapy [Parkinson Disease], gap 27 peptide, Mice, Inbred C57BL, Astrocytes, Connexin 43, antagonists & inhibitors [Connexin 43], Parkinson’s disease, therapeutic use [Connexins], etiology [Parkinson Disease], Microglia, Oligopeptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5747b2eb7ca27f8960d4853cef325aeTest
https://pub.dzne.de/record/163619Test

المؤلفون: Pingping Song, Lena F. Burbulla, Dimitri Krainc, Jianbin Zheng, Michaela E. Johnson, Weilan Jiang, Patrik Brundin

المصدر: JCI insight 6(19), e148649 (2021). doi:10.1172/jci.insight.148649
JCI Insight

مصطلحات موضوعية: drug effects [Glucosylceramidase], Parkinson's disease, Drug Evaluation, Preclinical, pharmacology [Antipsychotic Agents], drug effects [Dopaminergic Neurons], Pharmacology, genetics [Glucosylceramidase], Mice, genetics [Parkinson Disease], metabolism [alpha-Synuclein], Drug screens, drug effects [Induced Pluripotent Stem Cells], Chemistry, metabolism [Dopaminergic Neurons], Dopaminergic, Neurodegeneration, Parkinson Disease, General Medicine, LRRK2, metabolism [Induced Pluripotent Stem Cells], Parkinson disease, genetics [Parkinsonian Disorders], physiopathology [Parkinsonian Disorders], alpha-Synuclein, Glucosylceramidase, physiopathology [Parkinson Disease], drug effects [alpha-Synuclein], Research Article, Antipsychotic Agents, medicine.drug, pharmacology [Quetiapine Fumarate], Induced Pluripotent Stem Cells, metabolism [Parkinson Disease], metabolism [Parkinsonian Disorders], Glucosylceramides, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Quetiapine Fumarate, Parkinsonian Disorders, Dopamine, metabolism [Glucosylceramides], medicine, Animals, Humans, ddc:610, Dopaminergic Neurons, Drug Repositioning, medicine.disease, Symptomatic relief, Quetiapine, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], Glucocerebrosidase, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e57b68f83b8651105ddd9418b71ddTest
https://doi.org/10.1172/jci.insight.148649Test