المؤلفون: Rajdev, Lakshmi, Lee, Ju-Whei, Libutti, Steven K, Benson, Al B, Fisher, George A, Kunz, Pamela L, Hendifar, Andrew E, Catalano, Paul, O’Dwyer, Peter J

المصدر: Investigational New Drugs. 40(6)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Trials and Supportive Activities, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Neuroendocrine Tumors, Mechanistic Target of Rapamycin Complex 1, MTOR Inhibitors, Protein Kinase Inhibitors, Pancreatic Neoplasms, Sirolimus, Neuroectodermal Tumors, Primitive, PNET, Sapanisertib, mTORC1/2 inhibitor, Pharmacology and Pharmaceutical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/40s457s1Test

المؤلفون: Sehgal, Kartik, Serritella, Anthony, Liu, Mofei, ONeill, Anne, Nangia, Chaitali, Pappa, Theodora, Demeure, Michael J, Worden, Francis P, Haddad, Robert, Lorch, Jochen

المصدر: J Clin Endocrinol Metab ; ISSN:1945-7197

مصطلحات موضوعية: anaplastic thyroid carcinoma, mTORC1/2 inhibitor, radioiodine refractory thyroid cancer, sapanisertib

العلاقة: https://doi.org/10.1210/clinem/dgae443Test; https://pubmed.ncbi.nlm.nih.gov/38943664Test

الإتاحة: https://doi.org/10.1210/clinem/dgae443Test
https://pubmed.ncbi.nlm.nih.gov/38943664Test

المؤلفون: Ha-yeon Jee, Yoon-Gyeong Lee, Sol Lee, Rosalie Elvira, Hye-eun Seo, Ji-Yeon Lee, Jaeseok Han, Kyungho Lee

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 21; Pages: 11824

مصطلحات موضوعية: 4E-BP1, AZD8055, ERK1/2, mTORC1/2 inhibitor, p38, protein synthesis

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Biology; https://dx.doi.org/10.3390/ijms222111824Test

الإتاحة: https://doi.org/10.3390/ijms222111824Test

المؤلفون: Rosalie Elvira, Kyungho Lee, Jaeseok Han, Hye-Eun Seo, Sol Lee, Yoon-Gyeong Lee, Jiyeon Lee, Ha-Yeon Jee

المصدر: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11824, p 11824 (2021)

مصطلحات موضوعية: MAPK/ERK pathway, Carcinoma, Hepatocellular, protein synthesis, MAP Kinase Signaling System, QH301-705.5, Morpholines, 4E-BP1, p38 mitogen-activated protein kinases, Cellular homeostasis, p38, mTORC1, p38 Mitogen-Activated Protein Kinases, Article, Catalysis, Inorganic Chemistry, Eukaryotic initiation factor, Humans, Biology (General), Physical and Theoretical Chemistry, mTORC1/2 inhibitor, Protein kinase A, QD1-999, Molecular Biology, Spectroscopy, 4E‐BP1, ERK1/2, Chemistry, Kinase, Liver Neoplasms, Organic Chemistry, AZD8055, Hep G2 Cells, General Medicine, Neoplasm Proteins, Computer Science Applications, Cell biology, Enzyme Activation, Protein Biosynthesis, Phosphorylation, biological phenomena, cell phenomena, and immunity

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4915d54d34df83416999468b2de6d207Test

المؤلفون: Michel Vidaud, Laurent Lantieri, Béatrice Parfait, Mikael Hivelin, Nicolas Chapuis, Arnaud Hubas, Patrick Nusbaum, Eric Pasmant, Pierre Wolkenstein, Jennifer Varin, Laury Poulain, Ingrid Laurendeau

المساهمون: Génétique, physiopathologie et approches thérapeutiques des maladies héréditaires du système nerveux ( EA 7331 ), Université Paris Descartes - Paris 5 ( UPD5 ), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Chirurgie plastique, reconstructrice et esthétique [Pompidou], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ), Service de Biochimie et de Génétique Moléculaire, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Laboratoire d'Investigation Clinique ( LIC ), Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Département de dermatologie, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Centre de Référence des Neurofibromatoses, Service d’Hématologie Biologique, This work was supported in part by grants from Ligue Française Contre les Neurofibromatoses, Association Neurofibromatoses et Recklinghausen, Adebiopharm Association., Bos, Mireille, Génétique, physiopathologie et approches thérapeutiques des maladies héréditaires du système nerveux (EA 7331), Université Paris Descartes - Paris 5 (UPD5), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire d'Investigation Clinique (LIC), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Centre de Référence des Neurofibromatoses

المصدر: Oncotarget
Oncotarget, Impact journals, 2016, 7 (24), pp.35753-35767. 〈10.18632/oncotarget.7099〉
Oncotarget, 2016, 7 (24), pp.35753-35767. ⟨10.18632/oncotarget.7099⟩
Oncotarget, Impact journals, 2016, 7 (24), pp.35753-35767. ⟨10.18632/oncotarget.7099⟩

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Pathology, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Cell Cycle Proteins, mTORC1, Nerve Sheath Neoplasms, Malignant transformation, 0302 clinical medicine, Cell Movement, Neurofibromin 1, MEK inhibitor, TOR Serine-Threonine Kinases, Nuclear Proteins, Drug Synergism, 3. Good health, plexiform neurofibromas, Oncology, 030220 oncology & carcinogenesis, Benzamides, Nerve sheath neoplasm, Research Paper, Signal Transduction, medicine.medical_specialty, Neurofibromatosis 1, dual mTORC1/2 inhibitor, Morpholines, Primary Cell Culture, Malignant peripheral nerve sheath tumor, Antineoplastic Agents, Mechanistic Target of Rapamycin Complex 2, Mechanistic Target of Rapamycin Complex 1, 03 medical and health sciences, Inhibitory Concentration 50, MPNST, Cell Line, Tumor, medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Protein Kinase Inhibitors, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, PI3K/AKT/mTOR pathway, Cell Proliferation, Neurofibroma, Plexiform, Sirolimus, Cell growth, business.industry, Diphenylamine, medicine.disease, G1 Phase Cell Cycle Checkpoints, 030104 developmental biology, NF1, ras Proteins, Schwann Cells, business, Proto-Oncogene Proteins c-akt, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be42897066a85093555bd2247d5bd60Test
http://www.hal.inserm.fr/inserm-01399312Test