المؤلفون: Vanesa Nozal (9034427), Loreto Martínez-González (2911010), Marta Gomez-Almeria (11896116), Claudia Gonzalo-Consuegra (11896119), Paula Santana (3820921), Apirat Chaikuad (244322), Eva Pérez-Cuevas (11896122), Stefan Knapp (244328), Daniel Lietha (193525), David Ramírez (4053370), Sabrina Petralla (5681105), Barbara Monti (1504795), Carmen Gil (146118), Angeles Martín-Requero (11896125), Valle Palomo (356637), Eva de Lago (4767084), Ana Martinez (1313100)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Neuroscience, Pharmacology, Immunology, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising therapeutic strategy, motor neuron preservation, future als therapy, valuable lead compound, ttbk1 inhibitors emerge, 29 , valuable inhibitors, vivo <, tubulin kinase, translational modifications, spinal cord, proposing pyrrolopyrimidine, pathological hallmark, new avenue, m2 anti, inflammatory microglia, familiar patients, effective treatment, cell cultures, biological evaluation, animal models

العلاقة: https://figshare.com/articles/journal_contribution/TDP-43_Modulation_by_Tau_Tubulin_Kinase_1_Inhibitors_A_New_Avenue_for_Future_Amyotrophic_Lateral_Sclerosis_Therapy/17750151Test

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01942.s001Test

المؤلفون: Jayne Louise Wilson, Roberto Motterlini, Lucie Muchová, Thierry Martens, Aniket Nikam, Anthony Ollivier, Sylvie Manin, Roberta Foresti, Sabrina Djouadi, Michael Rivard

المساهمون: Institut de Chimie et des Matériaux Paris-Est (ICMPE), Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Redox Biology
Redox Biology, Elsevier, 2019, 20, pp.334-348. ⟨10.1016/j.redox.2018.10.020⟩
Redox Biology, Vol 20, Iss, Pp 334-348 (2019)

مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Lipopolysaccharide, NQO1, NAD(P)H:quinone oxidoreductase 1, Clinical Biochemistry, Anti-Inflammatory Agents, Gene Expression, AST, aspartate aminotransferase, Pharmacology, medicine.disease_cause, Nrf2, nuclear factor erythroid 2-related factor 2, TNF-α, tumor necrosis factor-α, Biochemistry, Antioxidants, Dual-activity molecules, Mice, chemistry.chemical_compound, ARG1, arginase 1, CO-RMs, CO-releasing molecules, 0302 clinical medicine, LC-MS/MS, liquid chromatography-tandem mass spectrometry, EPF, ethyl prop-2-yn-1-yl fumarate, IL-6, interleukin-6, lcsh:QH301-705.5, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Mice, Knockout, lcsh:R5-920, M2, anti-inflammatory macrophages, Carbon Monoxide, LDH, lactate dehydrogenase, Dimethyl fumarate, IL-10, interleukin-10, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, HMOX1, heme oxygenase-1 gene, 3. Good health, Nrf2 activators, CO, carbon monoxide, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, Cytokines, Microglia, Inflammation Mediators, medicine.symptom, lcsh:Medicine (General), Research Paper, M1, pro-inflammatory macrophages, IL-1β, interleukin-1β, NF-E2-Related Factor 2, GCLC, glutamate cysteine ligase C, Carbon monoxide (CO), Inflammation, HO-1, heme oxygenase-1 protein, GCLM, glutamate cysteine ligase M, 03 medical and health sciences, In vivo, ALT, alanine aminotransferase, medicine, Animals, [CHIM.COOR]Chemical Sciences/Coordination chemistry, ARG1, MCP-1/CCL2, monocyte chemoattractant protein-1, ALP, alkaline phosphatase, Macrophage phenotype, Activator (genetics), Macrophages, Organic Chemistry, In vitro, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), chemistry, HYCOs, HYbrid CO-releasing molecules, COHb, carbonmonoxy hemoglobin, Heme Oxygenase-1, 030217 neurology & neurosurgery, Oxidative stress, Hb, hemoglobin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe74c139a3bec4e624e4d5757b02f915Test
https://hal.archives-ouvertes.fr/hal-03124423Test