دورية أكاديمية
Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance
| العنوان: | Expression of CXCL12-CXCR4/CXCR7 chemokines in splenic fibrosis of cirrhotic spleen and its therapeutic significance |
|---|---|
| المؤلفون: | Yunfu Lv, Yejuan Li, XiaoYu Han, Ning Liu, Min Zeng |
| المصدر: | Archives of Medical Science, Vol 19, Iss 5, Pp 1569-1575 (2023) |
| بيانات النشر: | Termedia Publishing House, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | liver cirrhosis with hypersplenism, animal experiment, spleen fibrosis, chemotactic axis cxcl12-cxcr4/cxcr7, therapeutic significance, Medicine |
| الوصف: | Introduction To investigate the expression and treatment of chemokine CXCL12 and its receptor CXCR4/CXCR7. Methods The liver cirrhosis hypersplenism model of rats was made with CCL4, and then was detected by immunohistochemistry, Western blot and qRT-PCR. Results The area of spleen fibrosis in the model group was significantly larger than that in the control group (p < 0.01), and the expression of CXCL12, CXCR4 and CXCR7 in the model group was significantly higher than that in the control group (p < 0.01). Conclusions CXCL12-CXCR4/CXCR7 is abnormally high in splenic fibrosis, and blocking its high expression can slow down the occurrence of hypersplenism. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1734-1922 1896-9151 |
| العلاقة: | https://www.archivesofmedicalscience.com/Expression-of-CXCL12-CXCR4-CXCR7-chemokines-in-splenic-fibrosis-of-cirrhotic-spleen,170910,0,2.htmlTest; https://doaj.org/toc/1734-1922Test; https://doaj.org/toc/1896-9151Test |
| DOI: | 10.5114/aoms/170910 |
| الوصول الحر: | https://doaj.org/article/e21bf7b22c454144ba29bacc598a20e8Test |
| رقم الانضمام: | edsdoj.21bf7b22c454144ba29bacc598a20e8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17341922 18969151 |
|---|---|
| DOI: | 10.5114/aoms/170910 |