Long non-coding RNAs and their implications in cancer epigenetics
| العنوان: | Long non-coding RNAs and their implications in cancer epigenetics |
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| المؤلفون: | Sergio Verjovski-Almeida, Carlos DeOcesano-Pereira, Felipe Beckedorff, Murilo S. Amaral |
| المصدر: | Bioscience Reports, Vol 33, Iss 4, p e00061 (2013) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Bioscience Reports |
| بيانات النشر: | Portland Press, Biochemical Society, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | MLL, mixed-lineage leukaemia, HDM, histone demethylase, lcsh:Life, lcsh:QR1-502, Gene Expression, SMARCA2, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, type 2 (also known as BRM), HDAC, histone deacetylase, LSD1, lysine (K)-specific demethylase 1A, Review Article, medicine.disease_cause, Biochemistry, lcsh:Microbiology, Epigenesis, Genetic, Histones, CpG, cytosine phosphodiester bond guanine, lncRNA, long non-coding RNA, HOX, homeobox, long non-coding RNAs, Neoplasms, CTBP1-AS, C-terminal binding protein 1 antisense, PSF, phosphotyrosine-binding-associated splicing factor, Cancer epigenetics, CHD, chromodomain helicase DNA-binding protein, H3K27me3, histone 3 lysine 27 trymethylated, INK4b, inhibitor of cyclin-dependent kinase 4b, ARF, ADP-ribosylation factor, ANRASSF1, antisense non-coding RNA in the RASSF1A locus, Epigenesis, Regulation of gene expression, Genetics, EZH2, enhancer of zeste homologue 2, intergenic lncRNA, lincRNA, long intergenic non-coding RNA, ANRIL, antisense non-coding RNA in the INK4 locus, Nucleosomes, Gene Expression Regulation, Neoplastic, CRC, colorectal cancer, DNA methylation, RNA, Long Noncoding, S1, PCAT-1, prostate cancer-associated ncRNA transcript 1, Biophysics, Biology, regulatory RNA, RNA-guided gene silencing, INK4a, inhibitor of cyclin-dependent kinase 4a, XCI, X chromosome inactivation, medicine, Animals, Humans, Epigenetics, LICR, Ludwig Institute for Cancer Research, Molecular Biology, Gene, RNAPII, RNA polymerase II, Cancer, RASSF1A, Ras association (RalGDS/AF-6) domain family member 1 isoform A, Cell Biology, DNA Methylation, medicine.disease, cancer epigenetics, lcsh:QH501-531, XIST, X-inactive specific transcript, RNA, AR, androgen receptor, PRC, polycomb repressive complex, HMT, histone methyltransferase, HOTAIR, homeobox antisense intergenic RNA, Carcinogenesis, intronic lncRNA, Protein Processing, Post-Translational |
| الوصف: | LncRNAs (long non-coding RNAs) have emerged as key molecular players in the regulation of gene expression in different biological processes. Their involvement in epigenetic processes includes the recruitment of histone-modifying enzymes and DNA methyltransferases, leading to the establishment of chromatin conformation patterns that ultimately result in the fine control of genes. Some of these genes are related to tumorigenesis and it is well documented that the misregulation of epigenetic marks leads to cancer. In this review, we highlight how some of the lncRNAs implicated in cancer are involved in the epigenetic control of gene expression. While very few lncRNAs have already been identified as players in determining the cancer-survival outcome in a number of different cancer types, for most of the lncRNAs associated with epigenetic regulation only their altered pattern of expression in cancer is demonstrated. Thanks to their tissue-specificity features, lncRNAs have already been proposed as diagnostic markers in specific cancer types. We envision the discovery of a wealth of novel spliced and unspliced intronic lncRNAs involved in epigenetic networks or in highly location-specific epigenetic control, which might be predominantly altered in specific cancer subtypes. We expect that the characterization of new lncRNA (long non-coding RNA)–protein and lncRNA–DNA interactions will contribute to the discovery of potential lncRNA targets for use in therapies against cancer. |
| اللغة: | English |
| تدمد: | 1573-4935 0144-8463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac8c7f2e713646aa0543a01e0419d3bTest http://www.bioscirep.org/bsr/033/e061/bsr033e061.htmTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5ac8c7f2e713646aa0543a01e0419d3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734935 01448463 |
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