التفاصيل البيبلوغرافية
| العنوان: |
Cooperative Weak Dispersive Interactions Actuate Catalysis in a Shape-Selective Abiological Racemase |
| المؤلفون: |
Yujia Wang (388097), Michel Rickhaus (3374642), Olivier Blacque (1483516), Kim K. Baldridge (1281105), Michal Juríček (1653619), Jay S. Siegel (1299627) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Evolutionary Biology, Immunology, Mental Health, Computational Biology, selective abiological racemase, relatively weak binding, planar transition state, like thermodynamic profile, jencks ’ concept, catalyst active site, bowl inversion acts, bowl system demonstrates, 293 k ), catalytic rate enhancements, shape selectivity arising, 4 , 2 , k <, catalytic system, , catalytic process, catalytic antibodies, simple box, product inhibition, potent inhibitor, observed (<, hapten resembling, >< sub |
| الوصف: |
A simple abiological host–guest system demonstrates racemase activity with catalytic rate enhancements of 10 4 without employing traditional functional groups. Cooperative weak interactions enhanced through shape-complementarity between the catalyst active site and the reaction transition state drive this activity, as proposed by Pauling for enzymes. In analogy to the Jencks’ concept of catalytic antibodies, it is shown that a hapten resembling the planar transition state of the bowl inversion acts as a potent inhibitor of this catalytic process. In contrast, no substrate/product inhibition is detected, and a relatively weak binding of the substrate is observed ( K a ≈ 10 2 M –1 at 293 K). This simple box-and-bowl system demonstrates that shape selectivity arising from cooperative dispersive forces suffices for the emergence of a catalytic system with an enzyme-like thermodynamic profile. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Cooperative_Weak_Dispersive_Interactions_Actuate_Catalysis_in_a_Shape-Selective_Abiological_Racemase/19126503Test |
| DOI: |
10.1021/jacs.1c11032.s001 |
| الإتاحة: |
https://doi.org/10.1021/jacs.1c11032.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.32BD8BDD |
| قاعدة البيانات: |
BASE |
