المؤلفون: Marianna Potenza (8554353), Assunta Giordano (6415493), Maria G. Chini (1987117), Anella Saviano (11616517), Christian Kretzer (6061916), Federica Raucci (6031298), Marina Russo (402978), Gianluigi Lauro (1355385), Stefania Terracciano (1355376), Ines Bruno (1355382), Maria Iorizzi (14241758), Robert K. Hofstetter (14241761), Simona Pace (1779802), Francesco Maione (127366), Oliver Werz (468489), Giuseppe Bifulco (186812)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, induced leukocyte migration, four novel 2, combinatorial virtual library, 2 × 10, strongly inhibiting pge, 50 , 2 ‑ aminoacyl, 2 , 5 , leukotriene biosynthesis inhibitors, 3 , vivo <, vitro <, leukotriene biosynthesis, unprecedented class, stimulated j774a, small set, showed prominent

العلاقة: https://figshare.com/articles/journal_contribution/Identification_of_2_Aminoacyl-1_3_4-thiadiazoles_as_Prostaglandin_E_sub_2_sub_and_Leukotriene_Biosynthesis_Inhibitors/21705530Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.2c00343.s001Test

المؤلفون: Mohamed Touaibia (333388), Diene Codou Faye (11919497), Jérémie A. Doiron (11919500), Audrey Isabel Chiasson (11919503), Sébastien Blanchard (2221318), Pierre-Philippe Roy (11919506), Marc E. Surette (333390)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Immunology, Developmental Biology, Chemical Sciences not elsewhere classified, validated therapeutic strategy, stimulated hek293 cells, poor pharmacokinetic profile, many edible plants, limited clinical use, certain inflammatory diseases, 9 , 5o , 5l , 5i , 20b , leukotriene biosynthesis catalyzed, bioisosterism sinapic acid, 34 compounds inhibited, 27 μm ), 20 μm ), predominant phenolic compound, new analogues synthesized, 27 μm, meta <, phenolic moiety, new molecules

العلاقة: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationship_Studies_of_New_Sinapic_Acid_Phenethyl_Ester_Analogues_Targeting_the_Biosynthesis_of_5_Lipoxygenase_Products_The_Role_of_Phenolic_Moiety_Ester_Function_and_Bioisosterism/18048602Test

الإتاحة: https://doi.org/10.1021/acs.jnatprod.1c00982.s001Test

المؤلفون: Blerina Shkodra-Pula, Christian Kretzer, Paul M. Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz, Ulrich S. Schubert

المصدر: Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Acetalated dextran, PLGA, Nanoparticles, Leukotriene biosynthesis, FLAP inhibitor, MPGES-1, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12951-020-00620-7Test; https://doaj.org/toc/1477-3155Test

الوصول الحر: https://doaj.org/article/43e24a3477bd41249fdd227f980656d3Test

المؤلفون: Marianna Potenza, Assunta Giordano, Maria G. Chini, Anella Saviano, Christian Kretzer, Federica Raucci, Marina Russo, Gianluigi Lauro, Stefania Terracciano, Ines Bruno, Maria Iorizzi, Robert K. Hofstetter, Simona Pace, Francesco Maione, Oliver Werz, Giuseppe Bifulco

المصدر: ACS Medicinal Chemistry Letters. 14:26-34

مصطلحات موضوعية: 4-thiadiazole, Anti-inflammatory activity, Combinatorial virtual screening, 2-Aminoacyl-1,3,4-thiadiazole, mPGES-1, Leukotriene biosynthesis pathway, Organic Chemistry, Drug Discovery, 2-Aminoacyl-1, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd7c39f58d18a9d89254f69d4069f5cTest
https://doi.org/10.1021/acsmedchemlett.2c00343Test

المؤلفون: Potenza, Marianna, Giordano, Assunta, Chini, Maria G, Saviano, Anella, Kretzer, Christian, Raucci, Federica, Russo, Marina, Lauro, Gianluigi, Terracciano, Stefania, Bruno, Ines, Iorizzi, Maria, Hofstetter, Robert K, Pace, Simona, Maione, Francesco, Werz, Oliver, Bifulco, Giuseppe

المساهمون: Potenza, Marianna, Giordano, Assunta, Chini, Maria G, Saviano, Anella, Kretzer, Christian, Raucci, Federica, Russo, Marina, Lauro, Gianluigi, Terracciano, Stefania, Bruno, Ine, Iorizzi, Maria, Hofstetter, Robert K, Pace, Simona, Maione, Francesco, Werz, Oliver, Bifulco, Giuseppe

مصطلحات موضوعية: Combinatorial virtual screening, 2-Aminoacyl-1,3,4-thiadiazole, mPGES-1, Leukotriene biosynthesis pathway, Anti-inflammatory activity

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000895685200001; volume:14; issue:1; firstpage:26; lastpage:34; numberofpages:9; journal:ACS MEDICINAL CHEMISTRY LETTERS; https://hdl.handle.net/11695/117478Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85143868000

الإتاحة: https://doi.org/10.1021/acsmedchemlett.2c00343Test
https://hdl.handle.net/11695/117478Test

المؤلفون: Magnusson, Cecilia, Ehrnström, Roy, Olsen, Jorgen, Sjölander, Anita

المصدر: Cancer Research. 67(19):9190-9198

مصطلحات موضوعية: Caco-2 Cells, Cell Differentiation: physiology, Apoptosis: physiology, Leukotriene: biosynthesis, Receptors, Adenocarcinoma: metabolism, Adenocarcinoma: pathology, Cell Growth Processes: physiology, Colorectal Neoplasms: metabolism, G0 Phase: physiology, Colorectal Neoplasms: pathology, Leukotriene: metabolism, Membrane Proteins: metabolism, Membrane Proteins: biosynthesis, Humans, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology

الوصول الحر: https://lup.lub.lu.se/record/656192Test
http://dx.doi.org/10.1158/0008-5472.CAN-07-0771Test

المؤلفون: Temml, V., Garscha, U., Romp, E., Schubert, G., Gerstmeier, J., Kutil, Z. (Zsófia), Matuszczak, B., Waltenberger, B., Stuppner, H., Werz, O., Schuster, D.

مصطلحات موضوعية: activating protein, drug discovery, leukotriene biosynthesis, inflammatory diseases, conformer generation, arachidonic-acid, flap, challenges, asthma, risk

العلاقة: urn:pissn: 2045-2322; urn:eissn: 2045-2322; http://hdl.handle.net/11104/0271773Test

الإتاحة: https://doi.org/10.1038/srep42751Test
http://hdl.handle.net/11104/0271773Test

المؤلفون: Christopher L. Rector, Robert C. Murphy

المصدر: Journal of Lipid Research, Vol 50, Iss 10, Pp 2064-2071 (2009)

مصطلحات موضوعية: transcellular metabolism, leukotriene biosynthesis, S100 protein, Biochemistry, QD415-436

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520307148Test; https://doaj.org/toc/0022-2275Test

الوصول الحر: https://doaj.org/article/bdbaed6f148f40ca8c3de3dbb7a24d8fTest

المؤلفون: Jennifer S. Dickinson Zimmer, Douglas F. Dyckes, David A. Bernlohr, Robert C. Murphy

المصدر: Journal of Lipid Research, Vol 45, Iss 11, Pp 2138-2144 (2004)

مصطلحات موضوعية: half-life, transcellular biosynthesis, leukotriene biosynthesis, Biochemistry, QD415-436

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0022227520341456Test; https://doaj.org/toc/0022-2275Test

الوصول الحر: https://doaj.org/article/8a7a6f1008fc40a19f19da598172b215Test

المؤلفون: Maria Wallert, Stephanie Höppener, Steffi Stumpf, Paul Klemm, Antje Vollrath, Blerina Shkodra-Pula, Ulrich S. Schubert, David Pretzel, Stefan Lorkowski, Oliver Werz, Stephanie Schubert, Paul M. Jordan, Erden Banoglu, Christian Kretzer, Andreas Koeberle

المصدر: Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Adult, lcsh:Medical technology, Neutrophils, lcsh:Biotechnology, Drug Compounding, Anti-Inflammatory Agents, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Nanoparticle, Leukotriene biosynthesis, Bioengineering, Applied Microbiology and Biotechnology, Dinoprostone, Flow cytometry, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, Dynamic light scattering, FLAP inhibitor, lcsh:TP248.13-248.65, medicine, Humans, Prostaglandin E2, Cytotoxicity, Cells, Cultured, Fluorescent Dyes, medicine.diagnostic_test, Chemistry, Research, PLGA, Dextrans, Isoxazoles, BRP-187, Bioavailability, Dextran, lcsh:R855-855.5, MPGES-1, Quinolines, Biophysics, Nanoparticles, Molecular Medicine, Dual inhibitor, Acetalated dextran, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddff5f61bfb27b0efd72d812cd9997c3Test
https://doi.org/10.21203/rs.3.rs-15745/v2Test