Background: This real-world study aims to investigate clinical efficacy and safety of CO2 cryotherapy combined with Kushen gel for chronic cervicitis. Methods: From June 2021 to December 2021, a total of 363 patients with chronic cervicitis treated in the Center for Diagnosis and Treatment of Cervical Diseases were selected. A total of 208 patients were treated with CO2 cryotherapy combined with Kushen gel, while 155 cases only received cervical CO2 cryotherapy. Results: The total effective rate of combined therapy for chronic cervicitis was 100%, with a higher cure rate than CO2 cryotherapy alone (p = 0.004), and it was significantly correlated with the degree of cervical inflammation (p
