المؤلفون: Wang S, Lin B, Liu W, Wei G, Li Z, Yu N, Xue X, Ji G

المصدر: Drug Design, Development and Therapy, Vol Volume 14, Pp 5077-5085 (2020)

مصطلحات موضوعية: acacetin, osteosarcoma, apoptosis, ros/jnk activation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/acacetin-induces-apoptosis-in-human-osteosarcoma-cells-by-modulation-o-peer-reviewed-article-DDDTTest; https://doaj.org/toc/1177-8881Test

الوصول الحر: https://doaj.org/article/9c576a42ac2b45719f826fb274a335b9Test

المؤلفون: Robert W. M. Min, Filbert W. M. Aung, Bryant Liu, Aliza Arya, Sanda Win

المصدر: Biomedicines; Volume 10; Issue 8; Pages: 2035

مصطلحات موضوعية: JNK, SAB, JNK activation loop, ROS, MAP kinase cascade, drug therapy, non-alcoholic steatohepatitis

وصف الملف: application/pdf

العلاقة: Drug Discovery; https://dx.doi.org/10.3390/biomedicines10082035Test

الإتاحة: https://doi.org/10.3390/biomedicines10082035Test

المؤلفون: Xi Liu, Qiong Li, Xiaolei Cheng, Zhichun Liu, Xiaoliang Zhao, Shuai Zhang, Guangli Yu, Xia Zhao, Jiejie Hao

المصدر: Chinese Medicine, Vol 15, Iss 1, Pp 1-12 (2020)

مصطلحات موضوعية: Oligomannuronate, Type 2 diabetes, Islet amyloid polypeptide, JNK activation, Mitochondrial dysfunction, RINm5F cells, Other systems of medicine, RZ201-999

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s13020-020-00310-4Test; https://doaj.org/toc/1749-8546Test

الوصول الحر: https://doaj.org/article/3df6c9de17724aa0a958ff19794ea969Test

المؤلفون: Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y

المصدر: Drug Design, Development and Therapy, Vol Volume 13, Pp 3091-3103 (2019)

مصطلحات موضوعية: Polyphyllin VI, Osteosarcoma, Apoptosis, Autophagy, JNK activation, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/polyphyllin-vi-induces-apoptosis-and-autophagy-in-human-osteosarcoma-c-peer-reviewed-article-DDDTTest; https://doaj.org/toc/1177-8881Test

الوصول الحر: https://doaj.org/article/52950f9976cb44689bbfd6be5dc5d265Test

المؤلفون: N Turkel (9856376), Marta Portela-Esteban (7509308), C Poon (9856379), J Li (5099381), AM Brumby (9856382), Helena Richardson (9481208)

مصطلحات موضوعية: Uncategorized, Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, Drosophila, Eye-antennal disc, Apico-basal cell polarity, Actin cytoskeletal regulators, BTB-ZF, Abrupt, RhoGEF2, Rac1, Src, Scribble, CELL-SHAPE CHANGES, ECTOPIC EYE DEVELOPMENT, ACTIN-CAPPING PROTEIN, TUMOR-SUPPRESSOR, JNK ACTIVATION, HIPPO PATHWAY, RHO-GTPASES, SIGNALING PATHWAY, TISSUE OVERGROWTH, PROSTATE-CANCER

العلاقة: https://figshare.com/articles/journal_contribution/Cooperation_of_the_BTB-Zinc_finger_protein_Abrupt_with_cytoskeletal_regulators_in_Drosophila_epithelial_tumorigenesis/13394168Test

الإتاحة: https://doi.org/10.26181/6004ef119a7a7Test

المؤلفون: Heijink, Anne Margriet, Talens, Francien, Jae, Lucas T, van Gijn, Stephanie E, Fehrmann, Rudolf S N, Brummelkamp, Thijn R, van Vugt, Marcel A T M

المصدر: Heijink , A M , Talens , F , Jae , L T , van Gijn , S E , Fehrmann , R S N , Brummelkamp , T R & van Vugt , M A T M 2019 , ' BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity ' , Nature Communications , vol. 10 , no. 1 , 100 . https://doi.org/10.1038/s41467-018-07927-yTest

مصطلحات موضوعية: NF-KAPPA-B, CANCER SUSCEPTIBILITY GENE, EMBRYONIC CELLULAR PROLIFERATION, SUSTAINED JNK ACTIVATION, DNA-DAMAGE RESPONSE, STRAND BREAK REPAIR, HOMOLOGOUS RECOMBINATION, CHROMOSOMAL INSTABILITY, MICE LACKING, HUMAN-CELLS

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/b16994ac-19f7-4ec9-a4ad-5afa59b52de7Test

الإتاحة: https://doi.org/10.1038/s41467-018-07927-yTest
https://hdl.handle.net/11370/b16994ac-19f7-4ec9-a4ad-5afa59b52de7Test
https://research.rug.nl/en/publications/b16994ac-19f7-4ec9-a4ad-5afa59b52de7Test
https://pure.rug.nl/ws/files/73990491/BRCA2_deficiency_instigates_cGAS_mediated_inflammatory_signaling_and_confers_sensitivity_to_tumor_necrosis_factor_alpha_mediated_cytotoxicity.pdfTest

المؤلفون: Radogna, F., Cerella, C., Gaigneaux, A., Christov, C., Dicato, M., Diederich, M.

المساهمون: Diederich, M.

مصطلحات موضوعية: OXIDATIVE STRESS, CANCER-CELLS, CARDIAC-GLYCOSIDES, CALOTROPIS-PROCERA, JNK ACTIVATION, AUTOPHAGY, DEATH, UNBS1450, TARGET, CROSSTALK

العلاقة: Oncogene, Vol.35 No.29, pp.3839-3853; https://hdl.handle.net/10371/197683Test; 000380753200009; 2-s2.0-84949293247; 562

الإتاحة: https://doi.org/10.1038/onc.2015.455Test
https://hdl.handle.net/10371/197683Test

المؤلفون: Catrysse, L., Ghahremani, M. Farhang, Vereecke, L., Youssef, S. A., Mc Guire, C., Sze, M., Weber, A., Heikenwalder, M., de Bruin, A., Beyaert, R., van Loo, G.

المصدر: Catrysse , L , Ghahremani , M F , Vereecke , L , Youssef , S A , Mc Guire , C , Sze , M , Weber , A , Heikenwalder , M , de Bruin , A , Beyaert , R & van Loo , G 2016 , ' A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death ' , Cell death & disease , vol. 7 , 2250 . https://doi.org/10.1038/cddis.2016.154Test

مصطلحات موضوعية: NF-KAPPA-B, TRAIL-INDUCED APOPTOSIS, HEPATOCELLULAR-CARCINOMA, SIGNALING COMPLEXES, CELL-PROLIFERATION, MEDIATED APOPTOSIS, LINEAR UBIQUITIN, JNK ACTIVATION, ENZYME A20, MICE

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/dc9eede1-fbb3-4db7-bfec-04b06872ae99Test

الإتاحة: https://doi.org/10.1038/cddis.2016.154Test
https://hdl.handle.net/11370/dc9eede1-fbb3-4db7-bfec-04b06872ae99Test
https://research.rug.nl/en/publications/dc9eede1-fbb3-4db7-bfec-04b06872ae99Test
https://pure.rug.nl/ws/files/40765778/A20_prevents_chronic_liver_inflammation_and_cancer_by_protecting_hepatocytes_from_death.pdfTest

المؤلفون: Marcel A. T. M. van Vugt, Thijn R. Brummelkamp, Anne Margriet Heijink, Stephanie E van Gijn, Rudolf S N Fehrmann, Francien Talens, Lucas T. Jae

المساهمون: Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), University of Zurich, van Vugt, Marcel A T M

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, 10(1):100. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, 10039 Institute of Medical Genetics, medicine.medical_treatment, NF-KAPPA-B, CANCER SUSCEPTIBILITY GENE, General Physics and Astronomy, 02 engineering and technology, CHROMOSOMAL INSTABILITY, HOMOLOGOUS RECOMBINATION, Interferon, ASK1, skin and connective tissue diseases, lcsh:Science, Multidisciplinary, Chemistry, 021001 nanoscience & nanotechnology, Nucleotidyltransferases, 3100 General Physics and Astronomy, female genital diseases and pregnancy complications, 3. Good health, Cytokine, STRAND BREAK REPAIR, Tumor necrosis factor alpha, Signal transduction, 0210 nano-technology, Signal Transduction, medicine.drug, Programmed cell death, Cell Survival, Science, 610 Medicine & health, 1600 General Chemistry, DNA-DAMAGE RESPONSE, EMBRYONIC CELLULAR PROLIFERATION, SUSTAINED JNK ACTIVATION, MICE LACKING, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, medicine, Humans, neoplasms, BRCA2 Protein, Inflammation, Tumor Necrosis Factor-alpha, HUMAN-CELLS, General Chemistry, NFKB1, 030104 developmental biology, Cell culture, Cancer research, 570 Life sciences, biology, lcsh:Q, Gene Deletion

وصف الملف: application/pdf; s41467-018-07927-y.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ab79c1e19556680c972035bd9fc32Test
http://link.springer.com/article/10.1038/s41467-018-07927-yTest

المؤلفون: Abigail O. Smith (11883787), Julie A. Jonassen (11883790), Kenley M. Preval (11883793), Roger J. Davis (8057576), Gregory J. Pazour (8086339)

مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Neuroscience, Pharmacology, Marine Biology, Cancer, Infectious Diseases, tubule epithelial cells, largely overlapping functions, polycystic kidney disease, inherited degenerative disease, proliferative signaling must, chronic kidney diseases, observe jnk activation, pathway promotes proliferation, transmembrane proteins polycystin, div >< p, afflicting approximately 1, jnk pathway inhibitors, jnk pathway, cystic disease, signaling contributes, fibrotic diseases, work suggests, uriniferous tubules, therapeutic target, terminal kinase, reduces proliferation

العلاقة: https://figshare.com/articles/figure/JNK_inhibition_reduces_fibrosis_in_juvenile_Pkd2_mutant_mice_/17700358Test

الإتاحة: https://doi.org/10.1371/journal.pgen.1009711.g005Test