دورية أكاديمية
Gene variants of adhesion molecules predispose to MS: A case-control study
| العنوان: | Gene variants of adhesion molecules predispose to MS: A case-control study |
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| المؤلفون: | Dardiotis E., Panayiotou E., Siokas V., Aloizou A.-M., Christodoulou K., Hadjisavvas A., Pantzaris M., Grigoriadis N., Hadjigeorgiou G.M., Kyriakides T. |
| المصدر: | Neurology: Genetics ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065019127&doi=10.1212%2fNXG.0000000000000304&partnerID=40&md5=ae3297d67cbfa60944e8e07353c10db9Test |
| سنة النشر: | 2019 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | cell adhesion molecule, fibronectin, fibronectin 1, integrin, intercellular adhesion molecule 1, itga4 protein, itgb1 protein, itgb7 protein, mucosal addressin cell adhesion molecule 1, osteopontin, PADGEM protein, protein, unclassified drug, vascular cell adhesion molecule 1, adult, Article, case control study, controlled study, Cyprus, female, gene frequency, gene linkage disequilibrium, genetic association, genetic code, genetic predisposition, genetic variability, genotype, Greece, human, major clinical study |
| الوصف: | ObjectiveTo examine the effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the development of MS.MethodsA total of 389 Greek MS cases and 336 controls were recruited by 3 MS centers in Cyprus and Greece. In total, 147 tagging single nucleotide polymorphisms across 9 genes encoding for P-selectin (SELP), integrins (ITGA4, ITGB1, and ITGB7), adhesion molecules (ICAM1, VCAM1, and MADCAM1), fibronectin 1 (FN1), and osteopontin (SPP1) were genotyped. The clinical end point of the study was diagnosis of MS according to the 2005 revised McDonald criteria. Permutation analysis was used for adjusting for multiple comparisons.ResultsOverall, 21 variants across SELP, ITGA4, ITGB1, ICAM1, VCAM1, MADCAM1, FN1, and SSP1 genes were each associated with MS (pperm < 0.05). The most significant were rs3917779 and rs2076074 (SELP), rs6721763 (ITGA4), and rs1250258 (FN1), all with a permutation p value of less than 1e-004.ConclusionsThe current study provides preliminary evidence that variants across genes encoding adhesion molecules, responsible for lymphocyte adhesion and trafficking within the CNS, are implicated in the risk of developing MS. © American Academy of Neurology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 23767839 |
| العلاقة: | http://hdl.handle.net/11615/73088Test |
| DOI: | 10.1212/NXG.0000000000000304 |
| الإتاحة: | https://doi.org/10.1212/NXG.0000000000000304Test http://hdl.handle.net/11615/73088Test |
| رقم الانضمام: | edsbas.E78F0F93 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23767839 |
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| DOI: | 10.1212/NXG.0000000000000304 |