Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn
| العنوان: | Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn |
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| المؤلفون: | Alejandro Torres-Quintanilla, Estibalitz Laresgoiti-Servitje, María Hernández-Trejo, Gerardo García-Rivas |
| المصدر: | PLoS ONE, Vol 11, Iss 11, p e0165229 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | gamma interferon inducible protein 10, CXCL10 protein, human, Maternal Health, labor, Biochemistry, Antioxidants, Body Mass Index, Endocrinology, 0302 clinical medicine, newborn, Pregnancy, cytokine, lcsh:Science, gamma interferon inducible protein 10 blood level, Innate Immune System, clinical article, adult, Fatty Acids, cytokine blood level, Lipids, interleukin 1beta blood level, multivariate analysis, pregnancy diabetes mellitus, Cytokines, irisin, medicine.medical_specialty, Endocrine Disorders, Offspring, hormone determination, Immunology, Adipokine, Article, 03 medical and health sciences, fibronectin, Myokine, Diabetes Mellitus, Humans, human, Interleukins, lcsh:R, Biology and Life Sciences, Neonates, Molecular Development, medicine.disease, Fibronectins, Chemokine CXCL10, 030104 developmental biology, plasma protein, umbilical cord blood, Linear Models, lcsh:Q, fatty acid, Body mass index, fetus blood, Biomarkers, Developmental Biology, 0301 basic medicine, obesity, interleukin 1beta, antioxidant, Physiology, interleukin 7 blood level, lcsh:Medicine, Overweight, Umbilical cord, interleukin 5 blood level, Immune Physiology, Medicine and Health Sciences, Multidisciplinary, mother, Obstetrics and Gynecology, Hematology, biological marker, Fetal Blood, Body Fluids, medicine.anatomical_structure, female, Physiological Parameters, interleukin derivative, young adult, blood sampling, total antioxidant capacity, Anatomy, medicine.symptom, Research Article, FNDC5 protein, human, chemical parameters, venous blood, Adolescent, hormone blood level, Mothers, 030209 endocrinology & metabolism, interleukin 5, interleukin 7, progeny, body weight, male, blood, Internal medicine, Diabetes mellitus, medicine, controlled study, perinatal period, cesarean section, business.industry, statistical model, Infant, Newborn, irisin blood level, prediction, maternal blood, body mass, Diabetes, Gestational, 7 INGENIERÍA Y TECNOLOGÍA, Immune System, Metabolic Disorders, protein blood level, Women's Health, interleukin 1 receptor blocking agent, business, protein determination, metabolism, arterial blood |
| الوصف: | Introduction: Irisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy. However, the regulation of circulating irisin and its relationship with other cytokines has not been assessed thus far in pregnant women and their offspring. Objective: The aim of this study was to evaluate differences in irisin and cytokine concentrations between women at the end of pregnancy and their offspring, as well as the relationship between maternal and newborn irisin and maternal and newborn biomarkers. Methods: Twenty-eight mother/newborn pairs were included in this study. The following biomarkers were evaluated in maternal venous and arterial umbilical cord blood samples: irisin, 27 cytokine panel, total antioxidant capacity (TAC), total plasma protein, and free fatty acid concentration. Results: The newborns had significantly lower irisin concentrations compared to their mothers (p = 0.03), but this difference was present only in babies born from mothers without labor prior to cesarean section delivery (p = 0.01). No significant differences in maternal and newborn irisin concentrations were found between diabetic and non-diabetic mothers or between overweight/obese and normal weight mothers. A significant positive correlation was found between TAC level and irisin concentration in newborns. Maternal and newborn interleukin (IL)-1β, IL-1RA, IL-5, IL-7, and interferon gamma-induced protein (IP)-10 levels were significantly positively correlated with irisin concentrations in both study groups. In addition, maternal IL1β, IL-5, IL-7, and IP-10 levels positively predicted maternal irisin concentrations. Furthermore, arterial cord blood TAC and IL-1β and IL1-RA levels positively predicted newborn irisin concentrations. Multiple regression analyses showed that maternal IL-13 negatively predicted offspring irisin levels (p = 0.03) and that maternal IL-1β positively predicted newborn irisin concentrations (p = 0.046). Conclusion: No evidence was found that serum irisin concentrations in mothers at pregnancy termination or those of their newborns correlated with maternal body mass index, the presence of diabetes mellitus, or free fatty acid levels. However, the results of this study indicated that cytokines might predict irisin concentration in mothers and their offspring, although interactions between irisin levels during pregnancy and the newborn have not yet been fully elucidated. © 2016 Hernandez-Trejo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3f14d7141176a8634121c351ab96b6Test http://europepmc.org/articles/PMC5102349?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4c3f14d7141176a8634121c351ab96b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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