دورية أكاديمية
IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis
| العنوان: | IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis |
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| المؤلفون: | Valle Noguera, Ana, Sancho Temiño, Lucía, Castillo González, Raquel, Villa Gómez, Cristina, Gomez Sánchez, María José, Ochoa Ramos, Anne, González Granado, José María, Cruz Adalia, Aranzazu |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 612.017, CP: Immunology, Citrobacter rodentium, HIF-1α, IL-18, IL-22, TLR2, colitis, group 3 innate lymphoid cells, infection, innate RORγt(+) cells, Inmunología, 2412.99 Otras |
| الوصف: | Group 3 innate lymphoid cells (ILC3s) are vital for defending tissue barriers from invading pathogens. Hypoxia influences the production of intestinal ILC3-derived cytokines by activating HIF. Yet, the mechanisms gov- erning HIF-1a in ILC3s and other innate RORgt+ cells during in vivo infections are poorly understood. In our study, transgenic mice with specific Hif-1a gene inactivation in innate RORgt+ cells (RAG1KO HIF- 1a6Rorc) exhibit more severe colitis following Citrobacter rodentium infection, primarily due to the inability to upregulate IL-22. We find that HIF-1a6Rorc mice have impaired IL-22 production in ILC3s, while non- ILC3 innate RORgt+ cells, also capable of producing IL-22, remain unaffected. Furthermore, we show that IL-18, induced by Toll-like receptor 2, selectively triggers IL-22 in ILC3s by transcriptionally upregulating HIF-1a, revealing an oxygen-independent regulatory pathway. Our results highlight that, during late-stage C. rodentium infection, IL-18 induction in the colon promotes IL-22 through HIF-1a in ILC3s, which is crucial for protection against this pathogen. ; Ministerio de Ciencia e Innovación ; Instituto de Salud Carlos III (ISCIII) ; European Regional Development Fund ; Depto. de Inmunología, Oftalmología y ORL ; Fac. de Medicina ; TRUE ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2211-1247 |
| العلاقة: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-093647-B-I00/ES/CONTROL DE LA REGULACION METABOLICA Y MOLECULAR MEDIADA POR HIF-1A EN LAS CELULAS INNATAS LINFOIDES/; PID2021-122780OB-I00; CNS2022-135365; info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00306/ES/INMUNOLOGIA, INMUNOPATOLOGIA Y TERAPIA EN ENFERMEDAD INFLAMATORIA INTESTINAL/; https://hdl.handle.net/20.500.14352/92186Test; Valle-Noguera A, Sancho-Temiño L, Castillo-González R, Villa-Gómez C, Gomez-Sánchez MJ, Ochoa-Ramos A, Yagüe-Fernández P, Soler Palacios B, Zorita V, Raposo-Ponce B, González-Granado JM, Aragonés J, Cruz-Adalia A. IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis. Cell Rep. 2023 Dec 26;42(12):113508. doi:10.1016/j.celrep.2023.113508. Epub 2023 Nov 28. PMID: 38019650.; https://www.sciencedirect.com/journal/cell-reportsTest |
| DOI: | 10.1016/j.celrep.2023.113508 |
| الإتاحة: | https://doi.org/20.500.14352/92186Test https://doi.org/10.1016/j.celrep.2023.113508Test https://hdl.handle.net/20.500.14352/92186Test https://www.sciencedirect.com/journal/cell-reportsTest |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; open access |
| رقم الانضمام: | edsbas.4976F53 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22111247 |
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| DOI: | 10.1016/j.celrep.2023.113508 |