Sialic acid O-acetylation: From biosynthesis to roles in health and disease
| العنوان: | Sialic acid O-acetylation: From biosynthesis to roles in health and disease |
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| المؤلفون: | Thomas J. Boltje, Heleen de Jong, Sam J. Moons, Eline A. Visser, Suzanne B. P. E. Timmermans, Christian Büll |
| المصدر: | The Journal of Biological Chemistry Journal of Biological Chemistry, 297, 1-19 Journal of Biological Chemistry, 297, 2, pp. 1-19 Visser, E A, Moons, S J, Timmermans, S B P E, de Jong, H, Boltje, T J & Büll, C 2021, ' Sialic acid O-acetylation : From biosynthesis to roles in health and disease ', Journal of Biological Chemistry, vol. 297, no. 2, 100906, pp. 1-19 . https://doi.org/10.1016/j.jbc.2021.100906Test |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, SOAT, sialic acid O-acetyl transferase, Biochemistry, GBP, glycan-binding protein, chemistry.chemical_compound, IA/B/C/DV, Influenza A/B/C/D virus, KDN, 2-keto-3-deoxynononic acid, N-Glycolylneuraminic acid, S protein, spike protein, Disease, SIAE, sialic acid O-acetyl esterase, SDAV, sialodacryoadenitis virus, sialic acid O-acetyl transferases (SOATs), biology, EHEC, enterohemorrhagic Escherichia coli, Glycobiology, BCoV, bovine coronavirus, CMP, cytidine 5′-monophosphate, Acetylation, MERS-CoV, Middle East respiratory syndrome coronavirus, MHV-S, murine hepatitis virus strain S, NA, neuraminidase, CPS, capsular polysaccharides, O-Ac, O-acetyl, Glycan, HE, hemagglutinin esterase protein, O-acetylation, SARS-CoV, severe acute respiratory syndrome coronavirus, Hemagglutinin (influenza), Synthetic Organic Chemistry, Siglec, sialic acid-binding immunoglobulin-like lectin, 03 medical and health sciences, glycan modifications, SDG 3 - Good Health and Well-being, glycobiology, Acetyltransferases, Polysaccharides, Sia, sialic acid, NPL, neuraminic acid pyruvate-lyase, Animals, Humans, Molecular Biology, Ac-CoA, acetyl-coenzyme A, Glycoproteins, 030102 biochemistry & molecular biology, MUC, mucin, JBC Reviews, HEF, hemagglutinin esterase fusion protein, SIGLEC, Cell Biology, ALL, acute lymphoblastic leukemia, Neu5Gc, N-glycolylneuraminic acid, N-Acetylneuraminic Acid, CASD1, capsule structure1 domain containing 1, Neu5Ac, N-acetylneuraminic acid, Sialic acid, Biosynthetic Pathways, carbohydrates (lipids), 030104 developmental biology, chemistry, influenza C/D virus, biology.protein, sialic acid O-acetyl esterases (SIAEs), CMAH, CMP-Neu5Ac hydroxylase, sLex, sialyl-Lewisx antigen, Neuraminidase, N-Acetylneuraminic acid, Carboxylic Ester Hydrolases, sialic acids, HA, hemagglutinin |
| الوصف: | Sialic acids are nine-carbon sugars that frequently cap glycans at the cell surface in cells of vertebrates as well as cells of certain types of invertebrates and bacteria. The nine-carbon backbone of sialic acids can undergo extensive enzymatic modification in nature and O-acetylation at the C-4/7/8/9 position in particular is widely observed. In recent years, the detection and analysis of O-acetylated sialic acids have advanced, and sialic acid-specific O-acetyltransferases (SOATs) and O-acetylesterases (SIAEs) that add and remove O-acetyl groups, respectively, have been identified and characterized in mammalian cells, invertebrates, bacteria, and viruses. These advances now allow us to draw a more complete picture of the biosynthetic pathway of the diverse O-acetylated sialic acids to drive the generation of genetically and biochemically engineered model cell lines and organisms with altered expression of O-acetylated sialic acids for dissection of their roles in glycoprotein stability, development, and immune recognition, as well as discovery of novel functions. Furthermore, a growing number of studies associate sialic acid O-acetylation with cancer, autoimmunity, and infection, providing rationale for the development of selective probes and inhibitors of SOATs and SIAEs. Here, we discuss the current insights into the biosynthesis and biological functions of O-acetylated sialic acids and review the evidence linking this modification to disease. Furthermore, we discuss emerging strategies for the design, synthesis, and potential application of unnatural Oacetylated sialic acids and inhibitors of SOATs and SIAEs that may enable therapeutic targeting of this versatile sialic acid modification. |
| وصف الملف: | application/pdf |
| تدمد: | 1083-351X 0021-9258 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704561863100cd1be53c62370b397510Test https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/245797Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....704561863100cd1be53c62370b397510 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1083351X 00219258 |
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