دورية أكاديمية
Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration
| العنوان: | Curdlan-Decorated Fullerenes Mitigate Immune-Mediated Hepatic Injury for Autoimmune Hepatitis Therapeutics via Reducing Macrophage Infiltration |
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| المؤلفون: | Chenglong Fei, Lei Liu, Hedong Qi, Yuyang Peng, Jingfen Han, Chunru Wang, Xue Li |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Physiology, Immunology, Space Science, Chemical Sciences not elsewhere classified, nuclear factor kappa, mediated hepatic injury, inevitable undesired outcomes, induced hepatocyte apoptosis, hepatic inflammation contributes, findings may open, serum alanine aminotransferase, decorated fullerene nanoparticle, thus ameliorating immune, inhibiting inflammatory cytokines, f primarily distributes, aggravate liver damage, inflammatory cytokines, fullerene materials, aspartate aminotransferase, severe immune, immune homeostasis, alleviate immune, subsequently suppresses, signal pathway, novel avenues |
| الوصف: | Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease whose standard of care is immunosuppressive treatment with inevitable undesired outcomes. Macrophage is acknowledged to aggravate liver damage, providing a promising AIH therapeutic target. Accordingly, in this study, a kind of curdlan-decorated fullerene nanoparticle (Cur-F) is fabricated to alleviate immune-mediated hepatic injury for treating AIH via reducing macrophage infiltration in a concanavalin A (Con A)-induced AIH mouse model. After intravenous administration, Cur-F primarily distributes in liver tissues, efficiently eliminates the excessive reactive oxygen species, significantly attenuates oxidative stress, and subsequently suppresses the nuclear factor kappa-B-gene binding (NF-κB) signal pathway, resulting in the lowered production of pro-inflammatory cytokines and the balancing of the immune homeostasis with the prevention of macrophage infiltration in the liver. The regulation of hepatic inflammation contributes to inhibiting inflammatory cytokines-induced hepatocyte apoptosis, decreasing the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents and thus ameliorating immune-mediated hepatic injury. Notably, there is no detectable toxicity to the body. Our findings may open up novel avenues for AIH based on curdlan and fullerene materials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Curdlan-Decorated_Fullerenes_Mitigate_Immune-Mediated_Hepatic_Injury_for_Autoimmune_Hepatitis_Therapeutics_via_Reducing_Macrophage_Infiltration/25058842Test |
| DOI: | 10.1021/acsami.3c16168.s001 |
| الإتاحة: | https://doi.org/10.1021/acsami.3c16168.s001Test https://figshare.com/articles/journal_contribution/Curdlan-Decorated_Fullerenes_Mitigate_Immune-Mediated_Hepatic_Injury_for_Autoimmune_Hepatitis_Therapeutics_via_Reducing_Macrophage_Infiltration/25058842Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.53D8DC4F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsami.3c16168.s001 |
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