التفاصيل البيبلوغرافية
| العنوان: |
Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation |
| المؤلفون: |
Changyu Wu (1485628), Qing Hu (152962), Xichun Peng (530604), Jianming Luo (430422), Guangwen Zhang (7120487) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Genetics, Physiology, Pharmacology, Ecology, Immunology, Marine Biology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, serum uric acid, metabolic disease hyperuricemia, restore kidney function, uric acid metabolism, model group rats, induced kidney inflammation, induced intestinal dysfunction, mfpp attenuated hua, kidney histopathology, purine metabolism, intestinal barrier, hua rats, therapeutic strategy, results showed, relieve hua, related genes, potassium oxonate, nr4a3 <, mfpp restored, mfpp ), marine fish |
| الوصف: |
The metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown to be effective in alleviating HUA. In this study, HUA rats were induced by potassium oxonate with 100 mg/kg (L), 200 mg/kg (M), and 400 mg/kg (H) of marine fish protein peptide (MFPP). The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation. Meanwhile, MFPP restored the abundance of beneficial bacteria, including Lactobacillus, Blautia, Colidextribacter, and Intestinimonas. MFPP further repaired the intestinal barrier by recovering the expression of gene Ildr2 encoding the tricellular tight junction protein ILDR2 and the immune-related genes Ccr7 and Nr4a3 and also regulated the expression of Entpd8 and Cyp27b1 to restore kidney function and uric acid metabolism. MFPP was proved to have potential as a therapeutic strategy to be included in dietary intervention to relieve HUA. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Marine_Fish_Protein_Peptide_Regulating_Potassium_Oxonate-Induced_Intestinal_Dysfunction_in_Hyperuricemia_Rats_Helps_Alleviate_Kidney_Inflammation/21749454Test |
| DOI: |
10.1021/acs.jafc.2c04017.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.2c04017.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.EFED68C3 |
| قاعدة البيانات: |
BASE |
