دورية أكاديمية
Neuroprotective potential of incretinomimetics ; Нейропротективный потенциал агонистов рецепторов глюкагоноподобного пептида 1-го типа
| العنوان: | Neuroprotective potential of incretinomimetics ; Нейропротективный потенциал агонистов рецепторов глюкагоноподобного пептида 1-го типа |
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| المؤلفون: | A. S. Kokin, L. A. Suplotova, T. S. Dushina, O. B. Makarova, А. С. Кокин, Л. А. Суплотова, Т. С. Душина, О. Б. Макарова |
| المصدر: | Meditsinskiy sovet = Medical Council; № 9 (2023); 40-46 ; Медицинский Совет; № 9 (2023); 40-46 ; 2658-5790 ; 2079-701X |
| بيانات النشر: | REMEDIUM GROUP Ltd. |
| سنة النشر: | 2023 |
| المجموعة: | Medical Council (E-Journal) / Медицинский Совет |
| مصطلحات موضوعية: | инкретиномиметики, neurodegenerative diseases, Parkinson’s disease, Alzheimer’s disease, glucagon-like peptide type 1 agonists, incretins, нейродегенеративные заболевания, болезнь Паркинсона, болезнь Альцгеймера, агонисты глюкагоноподобного пептида-1, инкретины |
| الوصف: | In the prescriptions of an endocrinologist to patients with diabetes mellitus, glucagon-like peptide agonists, belonging to the group that affects the incretin system of the body, have recently been increasingly appearing. In addition to the pronounced hypoglycemic effect and high safety, these drugs also have many pleiotropic properties due to the presence of glucagon-like peptide receptors in the vascular endothelium, kidneys, heart and nervous tissue. The purpose of this work is to describe the most studied neuroprotective effects of this class of drugs. As materials in the course of the work, studies of domestic and foreign colleagues published in the period from 2008 to 2022 were used. Our work has shown that the neuroprotective effect of GLP-1 is associated with the activation of the corresponding receptor systems in the central nervous system, which leads to increased cellular survival in ischemic conditions by reducing reactive oxygen species, stimulating beta-oxidation by mitochondria, and reducing pro-inflammatory cytokines. In addition, the analysis of the literature also established the positive role of GLP-1 in neurodegenerative diseases – drugs reduce the amount of unnormal proteins (alphasynuclein, microtubular T-peptide, etc.), reduce the activity of non-enzymatic glycation of proteins in hyperglycemia, as well as reduce insulin resistance. The effects described above were analyzed during preclinical trials of GLP-1, and also demonstrated their validity in human models during some clinical trials. However, the data obtained is not yet sufficient to form clear indications for this class of drugs in neurology, so the topic requires further study and large clinical trials. ; В назначениях врача-эндокринолога пациентам с сахарным диабетом 2 типа (СД2) в последнее время все чаще фигурируют агонисты рецепторов глюкагоноподобного пептида-1 (арГПП-1), относящиеся к группе, воздействующей на инкретиновую систему организма. Помимо выраженного сахароснижающего эффекта и безопасности, эти препараты также ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.21518/ms2023-159 |
| الإتاحة: | https://doi.org/10.21518/ms2023-159Test https://doi.org/10.14341/DM9841Test https://doi.org/10.14341/probl201763158-67Test https://doi.org/10.1016/j.molmet.2015.07.008Test https://doi.org/10.1073/pnas.1306799110Test https://doi.org/10.1016/j.intimp.2022.108995Test https://doi.org/10.1016/j.lfs.2019.116566Test https://doi.org/10.1126/scitranslmed.3007218Test https://doi.org/10.1016/B978-0-12-802761-5.00029-8Test https://doi.org/10.1016/jTest |
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| رقم الانضمام: | edsbas.2F8534BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.21518/ms2023-159 |
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