نتائج البحث - "genetics [Luminescent Proteins]"

1

Novel Hexb-based tools for studying microglia in the CNS

المؤلفون: Josef Priller, Melanie Meyer-Luehmann, Lukas Amann, Maximilian Lenz, Marta Joana Costa Jordão, Paolo d´Errico, Roman Sankowski, Steffen Jung, Marco Prinz, Chotima Böttcher, Takahiro Masuda, Katrin Kierdorf, Thomas Misgeld, Andreas Vlachos, Klaus-Peter Knobeloch, Ori Staszewski, Nicolas Snaidero

المصدر: Nature immunology 21(7), 802-815 (2020). doi:10.1038/s41590-020-0707-4

مصطلحات موضوعية: 0301 basic medicine, Intravital Microscopy, genetics [Luminescent Proteins], metabolism [Microglia], Mice, 0302 clinical medicine, pathology [Brain], Immunology and Allergy, Hexosaminidase, Gene Knock-In Techniques, RNA-Seq, genetics [CRISPR-Cas Systems], Microglia, Gene targeting, immunology [Macrophages], chemistry [Luminescent Proteins], immunology [Facial Nerve Injuries], immunology [Microglia], genetics [beta-Hexosaminidase beta Chain], medicine.anatomical_structure, immunology [Brain], Single-Cell Analysis, red fluorescent protein, Protein subunit, beta-Hexosaminidase beta Chain, Immunology, Central nervous system, genetics [Genetic Loci], Biology, Transfection, 03 medical and health sciences, Fate mapping, medicine, Animals, Humans, pathology [Encephalomyelitis, Autoimmune, Experimental], ddc:610, Gene, Luminescent Agents, cytology [Brain], pathology [Facial Nerve Injuries], genetics [Genes, Reporter], immunology [Encephalomyelitis, Autoimmune, Experimental], metabolism [beta-Hexosaminidase beta Chain], HEXB, Luminescent Proteins, 030104 developmental biology, nervous system, NIH 3T3 Cells, metabolism [Macrophages], chemistry [Luminescent Agents], Neuroscience, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f0083d00648c63fcf33340b5cb801fTest
https://doi.org/10.1038/s41590-020-0707-4Test

2

A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol

المؤلفون: Stefan Becker, Nora Wender, Claudia Trenkwalder, Hannes Verbarg, Timo Strohaeker, Thomas Offner, Markus Zweckstetter, Fitnat Buket Basmanav, Silvio O. Rizzoli, Felipe Opazo, Ivan Manzini, Christoph Gerdes, Brit Mollenhauer, Eugenio F. Fornasiero, Natalia Waal

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications 11(1), 2729 (2020). doi:10.1038/s41467-020-16575-0

مصطلحات موضوعية: Male, animal diseases, Cell, genetics [Luminescent Proteins], Diseases, Biochemistry, Cytosol, 0302 clinical medicine, heterocyclic compounds, metabolism [alpha-Synuclein], lcsh:Science, metabolism [Single-Domain Antibodies], Cells, Cultured, Aged, 80 and over, Neurons, genetics [Single-Domain Antibodies], 0303 health sciences, Chemistry, Middle Aged, chemistry [Luminescent Proteins], Fluorescence, 3. Good health, Cell biology, medicine.anatomical_structure, metabolism [Neurons], chemistry [Cytosol], genetics [alpha-Synuclein], alpha-Synuclein, Female, ddc:500, Intracellular, red fluorescent protein, Adult, Protein subunit, Science, Molecular imaging, Article, 03 medical and health sciences, medicine, Animals, Humans, metabolism [Luminescent Proteins], Rats, Wistar, Aged, 030304 developmental biology, Biomarkers, Neuroscience, Single-Domain Antibodies, nervous system diseases, Luminescent Proteins, HEK293 Cells, Microscopy, Fluorescence, Multiphoton, Proteasome, nervous system, Cell culture, cytology [Neurons], health occupations, lcsh:Q, metabolism [Cytosol], Biosensor, 030217 neurology & neurosurgery, cerebrospinal fluid [alpha-Synuclein]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf9c2b7ac498a69e1d31e5ac60b49edTest
http://link.springer.com/article/10.1038/s41467-020-16575-0Test

3

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

المؤلفون: Ewa Baczynska, David Baidoe-Ansah, Jakub Wlodarczyk, Luisa Strackeljan, Alexander Dityatev, Rahul Kaushik, Carla Cangalaya

المصدر: Cells
Cells 10(8), 1862 (2021). doi:10.3390/cells10081862
Cells, Vol 10, Iss 1862, p 1862 (2021)
Volume 10
Issue 8

مصطلحات موضوعية: 0301 basic medicine, Male, Dendritic spine, metabolism [Brevican], Synaptogenesis, pathology [Nerve Net], Aminopyridines, microglia, genetics [Luminescent Proteins], enhanced green fluorescent protein, metabolism [Microglia], drug effects [Microglia], Extracellular matrix, 0302 clinical medicine, parvalbumin, Biology (General), Brevican, metabolism [Nerve Net], gamma-Aminobutyric Acid, Microglia, Chemistry, Perineuronal net, metabolism [Electrical Synapses], brevican, pathology [Microglia], General Medicine, pathology [CA1 Region, Hippocampal], Cell biology, medicine.anatomical_structure, Excitatory postsynaptic potential, pexidartinib, red fluorescent protein, metabolism [Extracellular Matrix], QH301-705.5, extracellular matrix, Green Fluorescent Proteins, CX3C Chemokine Receptor 1, toxicity [Aminopyridines], genetics [CX3C Chemokine Receptor 1], Mice, Transgenic, Slc17a7 protein, mouse, Article, 03 medical and health sciences, Bcan protein, mouse, Electrical Synapses, ddc:570, metabolism [Vesicular Glutamate Transport Protein 1], Neuropil, medicine, genetics [Green Fluorescent Proteins], Animals, Pyrroles, perisynaptic ECM, metabolism [Luminescent Proteins], metabolism [gamma-Aminobutyric Acid], CA1 Region, Hippocampal, perineuronal nets, metabolism [CA1 Region, Hippocampal], pathology [Extracellular Matrix], Excitatory Postsynaptic Potentials, Luminescent Proteins, 030104 developmental biology, pathology [Electrical Synapses], nervous system, metabolism [Green Fluorescent Proteins], Vesicular Glutamate Transport Protein 1, drug effects [CA1 Region, Hippocampal], synapses, Cx3cr1 protein, mouse, Nerve Net, 030217 neurology & neurosurgery, toxicity [Pyrroles]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769067983a625aeb97d4ae997b8c1323Test
https://pubmed.ncbi.nlm.nih.gov/34440631Test

4

Synapsin Condensates Recruit alpha-Synuclein

المؤلفون: Christian Hoffmann, Dragomir Milovanovic, Ayse Ulusoy, Giuseppe Morabito, R. Martin Vabulas, Roberto Sansevrino, Marcelo Ganzella, Chinyere Logan

المصدر: Journal of molecular biology 433(12), 166961 (2021). doi:10.1016/j.jmb.2021.166961

مصطلحات موضوعية: animal diseases, genetics [Luminescent Proteins], Synaptic Transmission, chemistry.chemical_compound, 0302 clinical medicine, synaptic vesicles, Structural Biology, metabolism [alpha-Synuclein], 0303 health sciences, Microscopy, Confocal, Chemistry, Brain, liquid-liquid phase separation, Synapsin, Cell biology, alpha-Synuclein, Synaptic Vesicles, Synapsin I, Macromolecular Substances, metabolism [Macromolecular Substances], Neurotransmission, Synaptic vesicle, Presynapse, 03 medical and health sciences, α-synuclein, mental disorders, Organelle, Animals, Humans, metabolism [Synapsins], ddc:610, metabolism [Luminescent Proteins], chemistry [Synapsins], Molecular Biology, metabolism [Synaptic Vesicles], 030304 developmental biology, Alpha-synuclein, Synucleinopathies, cytology [Brain], chemistry [Macromolecular Substances], synucleinopathies, Synapsins, synapsin 1, Rats, nervous system diseases, Luminescent Proteins, HEK293 Cells, chemistry [alpha-Synuclein], Microscopy, Fluorescence, nervous system, metabolism [Brain], 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d901a6c23049a5181d55fc4c99acef9fTest
https://doi.org/10.1016/j.jmb.2021.166961Test

5

Temporally precise control of single-neuron spiking by juxtacellular nanostimulation

المؤلفون: Lourens J. P. Nonkes, Paul H. E. Tiesinga, H. Rüdiger A. P. Geis, Arthur R. Houweling, Maik C. Stüttgen

المساهمون: Neurosciences

المصدر: Journal of Neurophysiology, 117(3), 1363-1378. American Physiological Society
Journal of Neurophysiology, 117, 3, pp. 1363-1378
Journal of Neurophysiology, 117, 1363-1378
Journal of neurophysiology 117(3), 1363-1378 (2017). doi:10.1152/jn.00479.2016

مصطلحات موضوعية: Male, 0301 basic medicine, 2-amino-5-phosphopentanoic acid, Patch-Clamp Techniques, Time Factors, Physiology, Computer science, Action Potentials, genetics [Luminescent Proteins], pharmacology [Valine], metabolism [Cytoskeletal Proteins], Mice, 0302 clinical medicine, Cortex (anatomy), physiology [Action Potentials], genetics [Nerve Tissue Proteins], 6-Cyano-7-nitroquinoxaline-2,3-dione, Neurons, General Neuroscience, pharmacology [Excitatory Amino Acid Antagonists], Valine, physiology [Neurons], medicine.anatomical_structure, pharmacology [6-Cyano-7-nitroquinoxaline-2,3-dione], Female, Spike (software development), Neuroinformatics, genetics [Synapsins], Models, Neurological, Biophysics, Mice, Transgenic, Nerve Tissue Proteins, Optogenetics, 03 medical and health sciences, medicine, drug effects [Neurons], Animals, metabolism [Synapsins], ddc:610, metabolism [Luminescent Proteins], activity regulated cytoskeletal-associated protein, genetics [Cytoskeletal Proteins], analogs & derivatives [Valine], metabolism [Nerve Tissue Proteins], drug effects [Action Potentials], Somatosensory Cortex, Synapsins, Electric Stimulation, Cytoskeletal Proteins, Luminescent Proteins, 030104 developmental biology, nervous system, Innovative Methodology, cytology [Somatosensory Cortex], Neuron, Whole cell, Excitatory Amino Acid Antagonists, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9743d8e76de315cb20e62f7db788359bTest
https://doi.org/10.1152/jn.00479.2016Test

6

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

المؤلفون: Pfeiffer, Thomas, Poll, Stefanie, Bancelin, Stephane, Angibaud, Julie, Inavalli, VVG Krishna, Keppler, Kevin, Mittag, Manuel, Fuhrmann, Martin, Nägerl, U Valentin

المصدر: eLife 7, e34700 (2018). doi:10.7554/eLife.34700
eLife, Vol 7 (2018)
eLife

مصطلحات موضوعية: Male, Mouse, hippocampus, spine plasticity, physiology [Hippocampus], Gene Expression, genetics [Luminescent Proteins], Mice, Genes, Reporter, super-resolution microscopy, methods [Molecular Imaging], Image Processing, Computer-Assisted, physiology [Neuronal Plasticity], Biology (General), ultrastructure [Hippocampus], Cerebral Cortex, anatomy & histology [Nerve Net], Neuronal Plasticity, physiology [Pyramidal Cells], Pyramidal Cells, physiology [Dendritic Spines], Molecular Imaging, Medicine, Female, physiology [Nerve Net], ultrastructure [Dendritic Spines], in vivo imaging, learning and memory, Research Article, genetics [Bacterial Proteins], instrumentation [Molecular Imaging], QH301-705.5, metabolism [Bacterial Proteins], Dendritic Spines, Science, anatomy & histology [Hippocampus], Green Fluorescent Proteins, Mice, Transgenic, methods [Microscopy, Fluorescence, Multiphoton], ultrastructure [Nerve Net], Bacterial Proteins, Memory, Animals, genetics [Green Fluorescent Proteins], metabolism [Luminescent Proteins], statistics & numerical data [Image Processing, Computer-Assisted], physiology [Memory], instrumentation [Microscopy, Fluorescence, Multiphoton], ultrastructure [Pyramidal Cells], Luminescent Proteins, Microscopy, Fluorescence, Multiphoton, yellow fluorescent protein, Bacteria, metabolism [Green Fluorescent Proteins], ultrastructure [Synapses], synapses, Nerve Net, physiology [Synapses], ddc:600, Neuroscience, surgery [Cerebral Cortex]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::89a655a23b1222635061fa14c41635c4Test

7

Method for Developing Optical Sensors Using a Synthetic Dye-Fluorescent Protein FRET Pair and Computational Modeling and Assessment

المؤلفون: Joshua A. Mitchell, William H. Zhang, Christian Henneberger, Megan L. O'Mara, Harald Janovjak, Colin J. Jackson, Michel K. Herde

المساهمون: Stein, Viktor

المصدر: Methods in Molecular Biology ISBN: 9781493969388
New York, NY : Springer New York, Methods in Molecular Biology 1596, 89-99 (2017). doi:10.1007/978-1-4939-6940-1_6
Synthetic Protein Switches / Stein, Viktor (Editor) ; New York, NY : Springer New York, 2017, Chapter 6 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-6938-8=978-1-4939-6940-1 ; doi:10.1007/978-1-4939-6940-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c9ad1170c11c5959c47a290f0ef010Test
https://doi.org/10.1007/978-1-4939-6940-1_6Test

8

Ancestral Protein Reconstruction and Circular Permutation for Improving the Stability and Dynamic Range of FRET Sensors

المؤلفون: Ben E. Clifton, Inmaculada Sanchez-Romero, Michel K. Herde, Harald Janovjak, Jason H. Whitfield, Colin J. Jackson, Christian Henneberger

المساهمون: Stein, Viktor

المصدر: New York, NY : Springer New York, Methods in Molecular Biology 1596, 71-87 (2017). doi:10.1007/978-1-4939-6940-1_5
Synthetic Protein Switches / Stein, Viktor (Editor) ; New York, NY : Springer New York, 2017, Chapter 5 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-6938-8=978-1-4939-6940-1 ; doi:10.1007/978-1-4939-6940-1
Methods in Molecular Biology ISBN: 9781493969388

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2702f6057e22e9f7aee5b4e0d705dfcTest
https://pub.dzne.de/record/144642Test

9

Tanycytes and a differential fatty acid metabolism in the hypothalamus

المؤلفون: Kristina, Hofmann, Christian, Lamberz, Kira, Piotrowitz, Nina, Offermann, Diana, But, Anja, Scheller, Ashraf, Al-Amoudi, Lars, Kuerschner

المصدر: Glia 65(2), 231-249 (2016). doi:10.1002/glia.23088

مصطلحات موضوعية: cytology [Hypothalamus], Male, pathology [Obesity], Ependymoglial Cells, Hypothalamus, genetics [Luminescent Proteins], Mice, Transgenic, chemically induced [Obesity], Ketone Bodies, In Vitro Techniques, Diet, High-Fat, Mice, Organ Culture Techniques, genetics [Glial Fibrillary Acidic Protein], Glial Fibrillary Acidic Protein, metabolism [Fatty Acids], Animals, Obesity, ddc:610, genetics [Excitatory Amino Acid Transporter 1], metabolism [Luminescent Proteins], metabolism [Ependymoglial Cells], metabolism [Astrocytes], Fatty Acids, metabolism [Excitatory Amino Acid Transporter 1], metabolism [Glial Fibrillary Acidic Protein], Slc1a3 protein, mouse, metabolism [Ketone Bodies], Oligodendrocyte Transcription Factor 2, Lipid Metabolism, metabolism [Hypothalamus], Mice, Inbred C57BL, Excitatory Amino Acid Transporter 1, Disease Models, Animal, Luminescent Proteins, Astrocytes, metabolism [Oligodendrocyte Transcription Factor 2], physiology [Lipid Metabolism], adverse effects [Diet, High-Fat], ultrastructure [Ependymoglial Cells]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f6b776d25f968ca57127829dc39f0838Test
https://pub.dzne.de/record/139027Test

10

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

المؤلفون: Anneke Kremer, Saak V. Ovsepian, Mario M. Dorostkar, G Aramuni, F. Van Leuven, Severin Filser, Christian Schön, Simon M. Ochs, Julia Pöschl, Jochen Herms

المصدر: Europe PubMed Central
Molecular psychiatry 20(4), 482-489 (2014). doi:10.1038/mp.2014.55
Molecular Psychiatry

مصطلحات موضوعية: Patch-Clamp Techniques, Dendritic spine, genetics [Luminescent Proteins], drug effects [Gene Expression Regulation], pharmacology [Tamoxifen], genetics [Gene Expression Regulation], Hippocampus, cytology [Cerebral Cortex], GABA Antagonists, Mice, Glycogen Synthase Kinase 3, genetics [Excitatory Postsynaptic Potentials], GSK-3, Conditional gene knockout, Picrotoxin, beta Catenin, Cerebral Cortex, Neurons, metabolism [beta Catenin], physiology [Dendritic Spines], Psychiatry and Mental health, genetics [Glycogen Synthase Kinase 3], Excitatory postsynaptic potential, Original Article, GSK3B protein, human, genetics [Bacterial Proteins], drug effects [Excitatory Postsynaptic Potentials], Antineoplastic Agents, Hormonal, metabolism [Bacterial Proteins], Dendritic Spines, Mice, Transgenic, AMPA receptor, In Vitro Techniques, Biology, pharmacology [Picrotoxin], Cellular and Molecular Neuroscience, Bacterial Proteins, Animals, drug effects [Neurons], ddc:610, Excitatory Amino Acid Agents, metabolism [Luminescent Proteins], Gsk3b protein, mouse, Molecular Biology, GSK3B, Glycogen Synthase Kinase 3 beta, pharmacology [Excitatory Amino Acid Agents], Excitatory Postsynaptic Potentials, pharmacology [Antineoplastic Agents, Hormonal], Luminescent Proteins, Tamoxifen, Electrophysiology, deficiency [Glycogen Synthase Kinase 3], Gene Expression Regulation, yellow fluorescent protein, Bacteria, cytology [Hippocampus], cytology [Neurons], Synaptic plasticity, pharmacology [GABA Antagonists], Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87263365e778bc6123c606053ba8c3c9Test
https://doi.org/10.1038/mp.2014.55Test

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