المؤلفون: Georg Jocher, Vincent Grass, Sarah K Tschirner, Lydia Riepler, Stephan Breimann, Tuğberk Kaya, Madlen Oelsner, M Sabri Hamad, Laura I Hofmann, Carl P Blobel, Carsten B Schmidt‐Weber, Ozgun Gokce, Constanze A Jakwerth, Jakob Trimpert, Janine Kimpel, Andreas Pichlmair, Stefan F Lichtenthaler

المصدر: EMBO Rep. 23:e54305 (2022)
EMBO reports 23(6), e54305 (2022). doi:10.15252/embr.202154305

مصطلحات موضوعية: EMBO23, EMBO24, EMBO31, Article, Articles, A549, apratastat, DPC-333, ectodomain shedding, syncytia formation, genetics [Amyloid Precursor Protein Secretases], ADAM17 Protein, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten, genetics [Spike Glycoprotein, Coronavirus], Biochemistry, Cell Fusion, DPC‐333, ADAM10 Protein, genetics [ADAM10 Protein], ddc:570, Genetics, Humans, Lung, Molecular Biology, SARS-CoV-2, Apratastat, Dpc-333, Ectodomain Shedding, Syncytia Formation, Membrane Proteins, COVID-19, Virus Internalization, ddc, genetics [Membrane Proteins], metabolism [Spike Glycoprotein, Coronavirus], Spike Glycoprotein, Coronavirus, Metalloproteases, Angiotensin-Converting Enzyme 2, Amyloid Precursor Protein Secretases, metabolism [Membrane Proteins]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa416da9c2b0eb78067136b09f89a20Test
https://doi.org/10.15252/embr.202154305Test

المؤلفون: Stefan F. Lichtenthaler, Paul Saftig, Tobias B. Huber, Lukas Heintz, Lisa Seipold, Lisa Schebsdat, Maja T. Lindenmeyer, Renate Lüllmann-Rauch, Sebastian Wetzel, Stephanie Zielinski, Oliver Kretz, Catherine Meyer-Schwesinger, Marlies Sachs, Wiebke Sachs, Julia Reichelt, Thorsten Wiech, Stephan A. Müller

المصدر: Journal of the American Society of Nephrology 32(6), 1389-1408 (2021). doi:10.1681/ASN.2020081213
J Am Soc Nephrol

مصطلحات موضوعية: 0301 basic medicine, Male, Proteomics, Nephrotic Syndrome, podocyte, physiology [Podocytes], ADAM10, glomerular disease, genetics [Amyloid Precursor Protein Secretases], Cell Communication, Podocyte, Blood Urea Nitrogen, ADAM10 Protein, genetics [ADAM10 Protein], Mice, 0302 clinical medicine, Glomerular Filtration Barrier, metabolism [Nephritis], Wnt Signaling Pathway, Cells, Cultured, pathology [Nephrotic Syndrome], Mice, Knockout, Nephritis, Chemistry, Cell adhesion molecule, Podocytes, metabolism [Podocytes], Wnt signaling pathway, pathology [Glomerular Filtration Barrier], General Medicine, Cadherins, adverse effects [Autoantibodies], metabolism [Nephrotic Syndrome], Cell biology, genetics [Membrane Proteins], medicine.anatomical_structure, Ectodomain, Nephrology, Creatinine, metabolism [ADAM10 Protein], Female, Proteases, metabolism [Cell Membrane], Adherens junction, 03 medical and health sciences, metabolism [Renal Insufficiency, Chronic], medicine, Cell Adhesion, Animals, Humans, ddc:610, Renal Insufficiency, Chronic, pathology [Podocytes], Autoantibodies, Cadherin, Cell Membrane, metabolism [Cadherins], Membrane Proteins, membranous nephropathy, metabolism [Amyloid Precursor Protein Secretases], Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Basic Research, Tissue Array Analysis, urine [Creatinine], pathology [Nephritis], Amyloid Precursor Protein Secretases, proteinuria, Transcriptome, physiopathology [Glomerular Filtration Barrier], 030217 neurology & neurosurgery, metabolism [Membrane Proteins]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd38702448fa14059c39567c6bc8975Test

المؤلفون: Edward T Davis, Michael G. Tomlinson, Lisa Seipold, Murat Keles, Natalie S. Poulter, Paul Saftig, Antonia Malinova, Stephan A. Mueller, Stefan F. Lichtenthaler, Alexandra L. Matthews, Bethany Cragoe, Hanh T.H. Nguyen, Stephen J. Briddon, Nicholas D. Holliday, Christos Pliotas, Chek Ziu Koo, Eric Rubinstein, Thomas A. McFarlane, Johanna Tüshaus, Michael C. Sykes, Justyna Szyroka, Eleanor Cull, Katie Willis, Haroon Ahmed, Alessandro Di Maio, Clara Apicella, Joelle Goulding, Peter J. Noy, Neale Harrison, Hung-En Hsia, Philip R. Morrison

المساهمون: German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Birmingham [Birmingham], University of Nottingham, UK (UON), Christian-Albrechts University of Kiel, University of Leeds, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Gestionnaire, HAL Sorbonne Université 5, Centre d'Immunologie et des Maladies Infectieuses (CIMI)

المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601Test

مصطلحات موضوعية: 0301 basic medicine, Immunogen, shedding membrane protein, Tetraspanins, ADAM10, metabolism [Multiprotein Complexes], genetics [Amyloid Precursor Protein Secretases], Biochemistry, Epitope, a disintegrin and metalloprotease, ADAM10 Protein, genetics [ADAM10 Protein], Jurkat Cells, Mice, Tetraspanin, Amyloid precursor protein, Mice, Knockout, biology, Tspan14, Tspan15, metabolism [Tetraspanins], Transmembrane protein, Cell biology, genetics [Membrane Proteins], ddc:540, metabolism [ADAM10 Protein], [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], metalloproteinase, medicine.drug_class, Monoclonal antibody, 03 medical and health sciences, medicine, Animals, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Molecular Biology, genetics [Tetraspanins], 030102 biochemistry & molecular biology, Membrane Proteins, ADAM, Cell Biology, Fusion protein, metabolism [Amyloid Precursor Protein Secretases], 030104 developmental biology, HEK293 Cells, tetraspanin, A549 Cells, monoclonal antibody, Multiprotein Complexes, biology.protein, genetics [Multiprotein Complexes], molecular cell biology, Amyloid Precursor Protein Secretases, metabolism [Membrane Proteins]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb363ab27157e6e501561ef205a029Test
https://hal.sorbonne-universite.fr/hal-03124330Test

المؤلفون: Javier Rueda-Carrasco, Paula Garcia-Esparcia, Inmaculada Crespo, José A. Esteban, Juan Fortea, Pilar Esteve, José M. Valpuesta, Alberto Lleó, Guadalupe Pereyra, Estrella Gómez-Tortosa, María Jesús Martín-Bermejo, Isidro Ferrer, Mercedes Domínguez, Jonathan E. Draffin, Paola Bovolenta, Inmaculada Moreno, Daniel Alcolea, Alberto Rábano, Ester Aso, África Sandonís, Michael T. Heneka, María Inés Mateo

المساهمون: Ministerio de Economía y Competitividad (España), Fundación Tatiana Pérez de Guzmán el Bueno, Fundación Ramón Areces

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature reviews / Neuroscience 22(8), 1258-1268 (2019). doi:10.1038/s41593-019-0432-1
NATURE NEUROSCIENCE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

مصطلحات موضوعية: 0301 basic medicine, metabolism [Intercellular Signaling Peptides and Proteins], genetics [Plaque, Amyloid], ADAM10, Long-Term Potentiation, genetics [Amyloid Precursor Protein Secretases], Plaque, Amyloid, genetics [Alzheimer Disease], APP protein, human, Pathogenesis, antagonists & inhibitors [Membrane Proteins], genetics [ADAM10 Protein], pathology [Alzheimer Disease], Mice, Amyloid beta-Protein Precursor, ADAM10 Protein, 0302 clinical medicine, Adam10 protein, mouse, drug therapy [Plaque, Amyloid], therapeutic use [Antibodies, Blocking], Metalloproteinase, General Neuroscience, genetics [Intercellular Signaling Peptides and Proteins], Long-term potentiation, Cell biology, genetics [Membrane Proteins], genetics [Amyloid beta-Protein Precursor], Intercellular Signaling Peptides and Proteins, metabolism [Alzheimer Disease], Amyloid, Transgene, Down-Regulation, Mice, Transgenic, Biology, biosynthesis [Membrane Proteins], 03 medical and health sciences, genetics [Brain Chemistry], Downregulation and upregulation, Secreted frizzled-related protein 1, Alzheimer Disease, ddc:570, mental disorders, Neurites, Animals, Humans, Sfrp1 protein, mouse, pathology [Plaque, Amyloid], Antibodies, Blocking, biosynthesis [ADAM10 Protein], Brain Chemistry, Membrane Proteins, 030104 developmental biology, biosynthesis [Amyloid Precursor Protein Secretases], Amyloid Precursor Protein Secretases, Neuroscience, 030217 neurology & neurosurgery, metabolism [Membrane Proteins], pathology [Neurites]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a0f9a5692c67f30d39b2f9105c61ffTest
http://hdl.handle.net/10261/193936Test

المؤلفون: Regina Feederle, Christian Haass, Akio Fukumori, Kai Schlepckow, Stefan F. Lichtenthaler, Gernot Kleinberger, Harald Steiner

المصدر: EMBO Molecular Medicine
EMBO molecular medicine 9(10), 1356-1365 (2017). doi:10.15252/emmm.201707672

مصطلحات موضوعية: 0301 basic medicine, THP-1 Cells, genetics [Amyloid Precursor Protein Secretases], genetics [Alzheimer Disease], genetics [ADAM10 Protein], ADAM10 Protein, 0302 clinical medicine, genetics [Membrane Glycoproteins], Sequence Analysis, Protein, TREM2, Serine, genetics [Receptors, Immunologic], Receptors, Immunologic, Membrane Glycoproteins, Microglia, metabolism [Serine], Neurodegeneration, neurodegeneration, metabolism [Receptors, Immunologic], Alzheimer's disease, regulated intramembrane proteolysis, ADAM17 protein, human, genetics [Membrane Proteins], medicine.anatomical_structure, Ectodomain, metabolism [ADAM10 Protein], Molecular Medicine, physiology [Phagocytosis], metabolism [Alzheimer Disease], Proteases, ADAM10 protein, human, genetics [ADAM17 Protein], Immunology, Mutation, Missense, Biology, ADAM17 Protein, metabolism [Cell Membrane], metabolism [Histidine], metabolism [ADAM17 Protein], 03 medical and health sciences, Phagocytosis, Alzheimer Disease, Report, medicine, Disintegrin, Humans, genetics [Phagocytosis], Histidine, ddc:610, Secretory pathway, TREM2 protein, human, Endoplasmic reticulum, Cell Membrane, Membrane Proteins, medicine.disease, Molecular biology, metabolism [Amyloid Precursor Protein Secretases], Immunity, Innate, 030104 developmental biology, HEK293 Cells, biology.protein, Genetics, Gene Therapy & Genetic Disease, Amyloid Precursor Protein Secretases, metabolism [Membrane Glycoproteins], metabolism [Membrane Proteins], 030217 neurology & neurosurgery, Reports, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f94700a37bd71d3afaa296089b0ff15Test
http://europepmc.org/articles/PMC5623859Test

المؤلفون: Larissa Haertle, Cécile Cieuta-Walti, Tobias Müller, André Mégarbané, Per Hoffmann, Steffi G. Riedel-Heller, Daniel L. A. van de Hove, Thomas Haaf, Nady El Hajj, Marcus Dittrich, Michael Wagner, Sophie Durand, Renzo J. M. Riemens, Mathilde Roche, Roy Lardenoije, Clotilde Mircher, Anna Maierhofer, Aimé Ravel, Martin Scherer, Alfredo Ramirez, Markus Leber, Samantha Stora

المساهمون: Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, RS: MHeNs - R3 - Neuroscience, Promovendi MHN

المصدر: Clinical Epigenetics
Clinical epigenetics 11(1), 195 (2019). doi:10.1186/s13148-019-0787-x
Clinical epigenetics, 11(1):195. BioMed Central Ltd

مصطلحات موضوعية: Oncology, Epigenomics, Male, Trisomy 21, Down syndrome, Intellectual disability, genetics [Amyloid Precursor Protein Secretases], CHILDREN, genetics [Alzheimer Disease], Epigenesis, Genetic, genetics [ADAM10 Protein], ADAM10 Protein, Infinium Methylation EPIC arrays, 0302 clinical medicine, Cognition, Germany, methods [Epigenomics], Senile plaques, DOWN-SYNDROME, Longitudinal Studies, Prospective Studies, Cognitive decline, Genetics (clinical), 0303 health sciences, DNA methylation, DEMENTIA, diagnosis [Alzheimer Disease], Alzheimer's disease, Alzheimer’s disease, Cognitive function, Trisomy, genetics [Membrane Proteins], Female, Adult, medicine.medical_specialty, IMMUNITY, 03 medical and health sciences, Young Adult, Alzheimer Disease, Internal medicine, Genetics, medicine, genetics [Down Syndrome], Dementia, Humans, Epigenetics, ddc:610, GENOME-WIDE ASSOCIATION, Molecular Biology, METAANALYSIS, 030304 developmental biology, RECEPTOR, business.industry, Research, Membrane Proteins, DNA Methylation, medicine.disease, Differentially methylated regions, Early Diagnosis, Amyloid Precursor Protein Secretases, business, 030217 neurology & neurosurgery, EPIGENETIC DYSREGULATION, Developmental Biology, Genome-Wide Association Study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2527d41481b05af1b4de175eeb3387Test
https://pubmed.ncbi.nlm.nih.gov/31843015Test