Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
| العنوان: | Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts |
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| المؤلفون: | Aulchenko, Yurii S, Ripatti, Samuli, Lindqvist, Ida, Boomsma, Dorret, Heid, Iris M, Pramstaller, Peter P, Penninx, Brenda W J H, Janssens, A Cecile J W, Wilson, James F, Spector, Tim, Martin, Nicholas G, Pedersen, Nancy L, Kyvik, Kirsten Ohm, Kaprio, Jaakko, Hofman, Albert, Freimer, Nelson B, Jarvelin, Marjo-Riitta, Gyllensten, Ulf, Campbell, Harry, Rudan, Igor, Johansson, Asa, Marroni, Fabio, Hayward, Caroline, Vitart, Veronique, Jonasson, Inger, Pattaro, Cristian, Wright, Alan, Hastie, Nick, Pichler, Irene, Hicks, Andrew A, Falchi, Mario, Willemsen, Gonneke, Hottenga, Jouke-Jan, de Geus, Eco J C, Montgomery, Grant W, Whitfield, John, Magnusson, Patrik, Saharinen, Juha, Perola, Markus, Silander, Kaisa, Isaacs, Aaron, Sijbrands, Eric J G, Uitterlinden, Andre G, Witteman, Jacqueline C M, Oostra, Ben A, Elliott, Paul, Ruokonen, Aimo, Sabatti, Chiara, Gieger, Christian, Meitinger, Thomas, Kronenberg, Florian, Döring, Angela, Wichmann, H-Erich, Smit, Johannes H, McCarthy, Mark I, van Duijn, Cornelia M, Peltonen, Leena, Consortium, ENGAGE |
| المساهمون: | Psychiatry, EMGO - Mental health, NCA - Anxiety & Depression, Epidemiology, Internal Medicine, Clinical Genetics, Biological Psychology, Neuroscience Campus Amsterdam - Anxiety & Depression, EMGO+ - Mental Health |
| المصدر: | Nature Genetics; Vol 41 Nature Genetics, 41(1), 47-55. Nature Publishing Group Aulchenko, Y S, Ripatti, S, Lindqvist, I, Boomsma, D, Heid, I M, Pramstaller, P P, Penninx, B W J H, Janssens, A C J W, Wilson, J F, Spector, T, Martin, N G, Pedersen, N L, Kyvik, K O, Kaprio, J, Hofman, A, Freimer, N B, Jarvelin, M-R, Gyllensten, U, Campbell, H, Rudan, I, Johansson, A, Marroni, F, Hayward, C, Vitart, V, Jonasson, I, Pattaro, C, Wright, A, Hastie, N, Pichler, I, Hicks, A A, Falchi, M, Willemsen, G, Hottenga, J-J, de Geus, E J C, Montgomery, G W, Whitfield, J, Magnusson, P, Saharinen, J, Perola, M, Silander, K, Isaacs, A, Sijbrands, E J G, Uitterlinden, A G, Witteman, J C M, Oostra, B A, Elliott, P, Ruokonen, A, Sabatti, C & Gieger, C & Meitinger, T 2009, ' Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts ', Nature Genetics, vol. 41, no. 1, pp. 47-55 . https://doi.org/10.1038/ng.269Test Aulchenko, Y S, Ripatti, S, Lindqvist, I, Boomsma, D, Heid, I M, Pramstaller, P P, Penninx, B W J H, Janssens, A C J W, Wilson, J F, Spector, T, Martin, N G, Pedersen, N L, Kyvik, K O, Kaprio, J, Hofman, A, Freimer, N B, Jarvelin, M-R, Gyllensten, U, Campbell, H, Rudan, I, Johansson, A, Marroni, F, Hayward, C, Vitart, V, Jonasson, I, Pattaro, C, Wright, A, Hastie, N, Pichler, I, Hicks, A A, Falchi, M, Willemsen, G, Hottenga, J-J, de Geus, E J C, Montgomery, G W, Whitfield, J, Magnusson, P, Saharinen, J, Perola, M, Silander, K, Isaacs, A, Sijbrands, E J G, Uitterlinden, A G, Witteman, J C M, Oostra, B A, Elliott, P, Ruokonen, A, Sabatti, C, Gieger, C, Meitinger, T, Kronenberg, F, Döring, A, Wichmann, H-E, Smit, J H, McCarthy, M I, van Duijn, C M, Peltonen, L & Consortium, ENGAGE 2008, ' Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts ', Nature Genetics, vol. 41, no. 1, pp. 47-55 . https://doi.org/10.1038/ng.269Test Aulchenko, Y S, Ripatti, S, Lindqvist, I, Boomsma, D I, Heid, I M, Pramstaller, P P, Penninx, B W J H, Janssen, A C J W, Wilson, J F, Spector, T, Martin, N G, Pedersen, N L, Kyvik, K O, Kaprio, J, Hofman, A, Freimer, N B, Jarvelin, M-R, Gyllensten, U, Campbell, H, Rudan, I, Johansson, A, Marroni, F, Hayward, C, Vitart, V, Jonasson, I, Pattar, C, Wright, A, Hastie, N, Pichler, I, Hicks, A A, Falchi, M, Willemsen, G, Hottenga, J J, de Geus, E J C, Montgomery, GW, Whitfield, J, Magnusson, P, Saharinen, J, Perola, M, Silander, K, Isaacs, A, Sijbrands, E J G, Uitterlinden, A G, Witteman, J C M, Oostra, B A, Elliott, P, Ruokonen, A, Sabatti, C, Gieger, C, Meitinger, T, Kronenberg, F, Döring, A, Wichmann, H-E, Smit, J H, McCarthy, M I, van Duijn, C M & Peltonen, L 2009, ' Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts ', Nature Genetics, vol. 41, no. 1, pp. 47-55 . https://doi.org/10.1038/ng.269Test Nature Genetics |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Netherlands Twin Register (NTR), Blood lipids, Coronary Disease, 030204 cardiovascular system & hematology, Body Mass Index, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, 80 and over, genetics, Genetics, 0303 health sciences, education.field_of_study, blood/genetics, Sex Characteristics, Genome, Adolescent, Adult, Aged, Aged, 80 and over, Body Mass Index, Cholesterol, HDL, blood, Cohort Studies, Coronary Disease, blood/genetics, European Continental Ancestry Group, genetics, Female, Genetic Predisposition to Disease, Genetic Testing, Genome, Human, genetics, Humans, Lipids, blood, Male, Metabolic Networks and Pathways, genetics, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, genetics, Quantitative Trait Loci, genetics, Sex Characteristics, Middle Aged, Lipids, 3. Good health, Cholesterol, Phenotype, Cohort, Female, lipids (amino acids, peptides, and proteins), Metabolic Networks and Pathways, Adult, medicine.medical_specialty, Adolescent, Population, European Continental Ancestry Group, Quantitative Trait Loci, Biology, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, blood, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Polymorphism, education, 030304 developmental biology, Aged, medicine.disease, Endocrinology, chemistry, Intima-media thickness, Body mass index, Dyslipidemia, Lipoprotein |
| الوصف: | Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 x 10(-8)), including 16 loci that were identified by previous GWA studies. The six newly identified loci in our cohort samples are ABCG5 (TC, P = 1.5 x 10(-11); LDL, P = 2.6 x 10(-10)), TMEM57 (TC, P = 5.4 x 10(-10)), CTCF-PRMT8 region (HDL, P = 8.3 x 10(-16)), DNAH11 (LDL, P = 6.1 x 10(-9)), FADS3-FADS2 (TC, P = 1.5 x 10(-10); LDL, P = 4.4 x 10(-13)) and MADD-FOLH1 region (HDL, P = 6 x 10(-11)). For three loci, effect sizes differed significantly by sex. Genetic risk scores based on lipid loci explain up to 4.8% of variation in lipids and were also associated with increased intima media thickness (P = 0.001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors. |
| وصف الملف: | application/pdf |
| تدمد: | 1061-4036 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab99e1c8be55715b0cafd37917c701d1Test https://doi.org/10.1038/ng.269Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ab99e1c8be55715b0cafd37917c701d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10614036 |
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