المؤلفون: Maronesi Bagio, Tony, Katsuda, Paulo Gil, Camilo Júnior, Deolino João, Xavier Júnior, José Cândido Caldeira

المصدر: HU Revista; v. 49 (2023); 1-3 ; 1982-8047 ; 0103-3123

مصطلحات موضوعية: Breast Neoplasms, Genes, erbB-2, Pathology, Neoplasias da Mama, Genes erbB-2, Antígeno Ki-67, Receptores de Estrogênio

وصف الملف: application/pdf

العلاقة: https://periodicos.ufjf.br/index.php/hurevista/article/view/42185/27129Test; https://periodicos.ufjf.br/index.php/hurevista/article/view/42185Test

الإتاحة: https://doi.org/10.34019/1982-8047.2023.v49.42185Test
https://periodicos.ufjf.br/index.php/hurevista/article/view/42185Test

المؤلفون: Novillo Villajos, Apolonia, Gaibar Alonso, María, Romero Lorca, Alicia, Malón, Diego, Antón, Beatriz, Moreno, Amalia, Fernández Santander, Ana

مصطلحات موضوعية: Neoplasias de la mama, Quimioterapia, Genes erbB-2, Cáncer, Tratamiento médico, Biotecnología

العلاقة: https://doi.org/10.3390/cancers15030763Test; Novillo, A., Gaibar, M., Romero-Lorca, A., Malón, D., Antón, B., Moreno, A., & Fernández-Santander, A. (2023). Her2 and bard1 polymorphisms in early her2-positive breast cancer patients: Relationship with response to neoadjuvant anti-her2 treatment. Cancers, 15(3), 763. https://doi.org/10.3390/cancers15030763Test; http://hdl.handle.net/11268/11864Test

الإتاحة: https://doi.org/10.3390/cancers15030763Test
http://hdl.handle.net/11268/11864Test

المؤلفون: Seonhoo Kim, Yeon-Ji Kim, Woo Chul Chung

المصدر: The Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1327-1337 (2021)

مصطلحات موضوعية: stomach neoplasms, recurrence, genes erbb-2, Medicine

وصف الملف: electronic resource

العلاقة: http://www.kjim.org/upload/pdf/kjim-2020-243.pdfTest; https://doaj.org/toc/1226-3303Test; https://doaj.org/toc/2005-6648Test

الوصول الحر: https://doaj.org/article/e125d86b02dc4c33baa8a1e63e2a48abTest

المؤلفون: Carolina Bautista Saiz, Monica María Mora Gómez, José Fernando Polo, Luz Dary Gutiérrez Castañeda

المصدر: Repertorio de Medicina y Cirugía (2022)

مصطلحات موضوعية: genes ERBB-2, proteína 7 unida al receptor del factor de crecimiento GRB7, cáncer de mama, transducción de señal, Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1119Test; https://doaj.org/toc/0121-7372Test; https://doaj.org/toc/2462-991XTest

الوصول الحر: https://doaj.org/article/3c9ed8e0f4fc4960b38e897fde9427e9Test

المؤلفون: Bautista Saiz, Carolina, Mora Gómez , Monica María, Polo, José Fernando, Gutiérrez Castañeda, Luz Dary

المصدر: https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1119Test.

مصطلحات موضوعية: genes ERBB-2, proteína 7 unida al receptor del factor de crecimiento GRB7, cáncer de mama, transducción de señal, ERBB-2 genes, growth factor receptor-bound protein 7 GRB7, breast cancer, signal transduction

وصف الملف: application/pdf

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Godone RLN, Leitão GM, Araújo NB, Castelletti CHM, Lima-Filho JL, Martins DBG. Clinical and molecular aspects of breast cancer: Targets and therapies. Biomed Pharmacother. Biomed Pharmacother. 2018;106:14-34. doi:10.1016/j.biopha.2018.06.066 6. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747-52. doi:10.1038/35021093. 7. Serrano Gómez S. Perfil molecular del cáncer de mama en la población colombiana: Pontificia Universidad Javeriana; 2016. 8. Kalinowski L, Saunus JM, McCart Reed AE, Lakhani SR. Breast Cancer Heterogeneity in Primary and Metastatic Disease. Adv Exp Med Biol. 2019;1152:75-104. doi:10.1007/978-3-030-20301-6_6 9. Vinatzer U, Dampier B, Streubel B, Pacher M, Seewald MJ, Stratowa C, et al. Expression of HER2 and the coamplified genes GRB7 and MLN64 in human breast cancer: quantitative real-time reverse transcription-PCR as a diagnostic alternative to immunohistochemistry and fluorescence in situ hybridization. Clin Cancer Res. 2005;11(23):8348-57. doi:10.1158/1078-0432.CCR-05-0841 10. Nadler Y, González AM, Camp RL, Rimm DL, Kluger HM, Kluger Y. Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer. Ann Oncol. 2010;21(3):466-73. doi:10.1093/annonc/mdp346 11. Luoh SW, Wagoner W, Wang X, Hu Z, Lai X, Chin K, et al. GRB7 dependent proliferation of basal-like, HER-2 positive human breast cancer cell lines is mediated in part by HER-1 signaling. Mol Carcinog. 2019;58(5):699-707. doi:10.1002/mc.22963 12. Kpetemey M, Chaudhary P, Van Treuren T, Vishwanatha JK. MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics. Oncotarget. 2016;7(34):54913-24. 13. Yin K, Ba Z, Li C, Xu C, Zhao G, Zhu S, et al. Overexpression of C35 in breast carcinomas is associated with tumor progression and lymphnode metastasis. Biosci Trends. 2015;9(6):386-92. doi:10.5582/bst.2015.01161 14. Zhao HB, Zhang XF, Wang HB, Zhang MZ. Migration and invasion enhancer 1 (MIEN1) is overexpressed in breast cancer and is a potential new therapeutic molecular target. Genet Mol Res. 2017;16(1). doi:10.4238/gmr16019380 15. Van Treuren T, Vishwanatha JK. CRISPR deletion of MIEN1 in breast cancer cells. PLoS One. 2018;13(10):e0204976. doi:10.1371/journal.pone.0204976 16. Kushwaha PP, Gupta S, Singh AK, Kumar S. Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis. Front Oncol. 2019;9:868. doi:10.3389/fonc.2019.00868 17. Chu PY, Tai YL, Shen TL. Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. Cells. 2019;8(5):435. doi:10.3390/cells8050435 18. Bivin WW, Yergiyev O, Bunker ML, Silverman JF, Krishnamurti U. GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma. Appl Immunohistochem Mol Morphol. 2017;25(8):553-558. doi:10.1097/PAI.0000000000000349 19. Sparano JA, Goldstein LJ, Childs BH, Shak S, Brassard D, Badve S, et al. Relationship between quantitative GRB7 RNA expression and recurrence after adjuvant anthracycline chemotherapy in triple-negative breast cancer. Clinical Cancer Research. 2011;17(22):7194-203. doi:10.1158/1078-0432.CCR-10-3357 20. Lucas-Fernández E, García-Palmero I, Villalobo A. Genomic organization and control of the grb7 gene family. Curr Genomics. 2008;9(1):60-68. doi:10.2174/138920208783884847 21. Tang Y, Yang S, Wang M, Liu D, Liu Y, Zhang Y, et al. Epigenetically altered miR‑193a‑3p promotes HER2 positive breast cancer aggressiveness by targeting GRB7. Int J Mol Med. 2019;43(6):2352-60. doi:10.3892/ijmm.2019.4167 22. Sang J, Kulkarni K, Watson GM, Ma X, Craik DJ, Henriques ST, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019;24(20):3739. doi:10.3390/molecules24203739. 23. Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, et al. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J Clin Invest. 1998;102(4):821-7. doi:10.1172/JCI2921 24. Gotovac JR, Liu DS, Yates MJ, Milne JV, Macpherson AA, Simpson KJ, et al. GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma. J Pathol. 2020;252(3):317-329. doi:10.1002/path.5528 25. Watson GM, Lucas WAH, Gunzburg MJ, Wilce JA. Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target. Front Mol Biosci. 2017;4:64. doi:10.3389/fmolb.2017.00064 26. Han DC, Shen TL, Guan JL. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 2001;20(44):6315-21. doi:10.1038/sj.onc.120477 27. Watson GM, Wilce JA. Direct Interaction between Calmodulin and the Grb7 RA-PH Domain. Int J Mol Sci. 2020;21(4):1336. doi:10.3390/ijms21041336. 28. Katoh K. FAK-Dependent Cell Motility and Cell Elongation. Cells. 2020;9(1):192. doi:10.3390/cells9010192 29. Alcalde J, González-Muñoz M, Villalobo A. Grb7-derived calmodulin-binding peptides inhibit proliferation, migration and invasiveness of tumor cells while they enhance attachment to the substrate. Heliyon. 2020;6(5):e03922. https://doi.org/10.1016/j.heliyon.2020.e03922Test 30. Watson GM, Kulkarni K, Brandt R, Del Borgo MP, Aguilar MI, Wilce JA. Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide. ACS Omega. 2017;2(2):670-677. doi:10.1021/acsomega.6b00561 31. Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem. 1997;272(5):2659-67. doi:10.1074/jbc.272.5.2659 32. García-Palmero I, Shah N, Ali NA, Daly RJ, Wilce JA, Villalobo A. Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain. Arch Biochem Biophys. 2020;687:108386. doi:10.1016/j.abb.2020.108386 33. Villalobo A, Ishida H, Vogel HJ, Berchtold MW. Calmodulin as a protein linker and a regulator of adaptor/scaffold proteins. Biochim Biophys Acta Mol Cell Res. 2018;1865(3):507-21. doi:10.1016/j.bbamcr.2017.12.004 34. Bradford AM, Koirala R, Park CK, Lyons BA. Characterization of the full-length human Grb7 protein and a phosphorylation representative mutant. J Mol Recognit. 2019;32(11):e2803. doi:10.1002/jmr.2803 35. Bai T, Luoh SW. GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formation. Carcinogenesis. 2008;29(3):473-9. doi:10.1093/carcin/bgm221 36. Pradip D, Bouzyk M, Dey N, Leyland-Jones B. Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules. Am J Cancer Res. 2013;3(2):173-95. 37. Shen TL, Guan JL. Grb7 in intracellular signaling and its role in cell regulation. Front Biosci. 2004;9:192-200. doi:10.2741/1229 38. Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, et al. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette. Mol Endocrinol. 2000;14(11):1750-75. doi:10.1210/mend.14.11.0553 39. Watson GM, Kulkarni K, Sang J, Ma X, Gunzburg MJ, Perlmutter P, et al. Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. J Med Chem. 2017;60(22):9349-59. https://doi.org/10.1021/acs.jmedchem.7b01320Test 40. Tai YL, Tung LH, Lin YC, Lu PJ, Chu PY, Wang MY, et al. Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. PLoS One. 2016;11(9):e0163617. doi:10.1371/journal.pone.0163617 41. Giricz O, Calvo V, Pero SC, Krag DN, Sparano JA, Kenny PA. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012;133(2):607-15. doi:10.1007/s10549-011-1822-6 42. Stein D, Wu J, Fuqua SA, Roonprapunt C, Yajnik V, D'Eustachio P, et al. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. EMBO J. 1994;13(6):1331-40. 43. Vermehren-Schmaedick A, Mhawech-Fauceglia P, Park BS, Pejovic T, Luoh SW. The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers. Oncotarget. 2020;11(24):2273-2289. doi:10.18632/oncotarget.27593 44. Luoh SW, Ramsey B, Hanlon Newell A, Troxell M, Hu Z, Chin K, et al. HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression. Springerplus. 2013;2:386. doi:10.1186/2193-1801-2-386 45. Watson GM, Gunzburg MJ, Ambaye ND, Lucas WAH, Traore DA, Kulkarni K, et al. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. J Med Chem. 2015;58(19):7707-18. doi:10.1021/acs.jmedchem.5b00609; https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1119/1863Test; Pre-Print; Revista Repertorio de Medicina y Cirugía; https://repositorio.fucsalud.edu.co/handle/001/3020Test; https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1119Test

الإتاحة: https://doi.org/10.3322/caac.21492Test
https://repositorio.fucsalud.edu.co/handle/001/3020Test
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1119Test

المؤلفون: Charles L, Vogel, Melody A, Cobleigh, Debu, Tripathy, John C, Gutheil, Lyndsay N, Harris, Louis, Fehrenbacher, Dennis J, Slamon, Maureen, Murphy, William F, Novotny, Michael, Burchmore, Steven, Shak, Stanford J, Stewart, Michael, Press

المصدر: Journal of Clinical Oncology. 41:1638-1645

مصطلحات موضوعية: Adult, Aged, 80 and over, Cancer Research, Gene Amplification, Antibodies, Monoclonal, Antineoplastic Agents, Breast Neoplasms, Genes, erbB-2, Middle Aged, Trastuzumab, Antibodies, Monoclonal, Humanized, Immunohistochemistry, Treatment Outcome, Oncology, Quality of Life, Humans, Female, Safety, skin and connective tissue diseases, In Situ Hybridization, Aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad728710b584bef814c355e69a2d35Test
https://doi.org/10.1200/jco.22.02516Test

المؤلفون: Cruz-López, Olga, Ner, Matilde, Nerín-Fonz, Francho, Jiménez-Martínez, Yaiza, Araripe, David, Marchal, Juan A., Boulaiz, Houria, Gutiérrez-de-Terán, Hugo, Campos, Joaquín M., Conejo-García, Ana

المساهمون: Cruz-López,O, Ner,M, Campos,JM, Conejo-García,A Department of Medicinal and Organic Chemistry, Faculty of Pharmacy, University of Granada, Granada, Spain. Cruz-López,O, Jiménez-Martínez,Y, Marchal,JA, Boulaiz,H, Conejo-García,A Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Granada, Spain. Nerín-Fonz,F, Araripe,D, Gutiérrez-de-Terán,H Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweeden. Jiménez-Martínez,Y, Boulaiz,H Biopathology and Medicine Regenerative Institute, University of Granada, Granada, Spain. Jiménez-Martínez,Y, Boulaiz,H Excellence Research Unit “Modeling Nature” (MNat), Department of Human Anatomy and Embryology, University of Granada, Granada, Spain., A. C. -G. is thankful to Consejería de Economía, Conocimiento, Empresas y Universidad of the Junta de Andalucía (Excellence Research Project P18-RT-1679) and the Oficina de Transferencia de Resultados de Investigación of the University of Granada (PR/17/006 project) for financial support. J. A. M. and H. B. thanks Instituto de Salud Carlos III (RTI2018-101309-B-C22), Fundación Mutua Madrileña (project FMM-AP16683-2017), Consejería de Salud Junta de Andalucía (PI-0089-2017) for financial support.

مصطلحات موضوعية: Antitumour, Pyroptosis, HER2, Receptor, Molecular modelling, Benzoxazepines, Cancer cell line, Antineoplásicos, Piroptosis, Genes erbB-2, Modelos moleculares, Línea celular tumoral, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation, Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Drug Screening Assays, Antitumor, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Molecular, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Molecular Structure, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protein Kinase Inhibitors, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases::Receptor, erbB-2

وصف الملف: application/pdf

العلاقة: Cruz-López O, Ner M, Nerín-Fonz F, Jiménez-Martínez Y, Araripe D, Marchal JA, et al. Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1553-1563; http://hdl.handle.net/10668/4437Test; PMC8279156

الإتاحة: https://doi.org/10.1080/14756366.2021.1948841Test
http://hdl.handle.net/10668/4437Test

المؤلفون: Carolina Bautista Saiz, Monica María Mora Gómez, José Fernando Polo, Luz Dary Gutiérrez Castañeda

المصدر: Repositorio Digital Institucional ReDi
Fundación Universitaria de Ciencias de la Salud-FUCS
instacron:Fundación Universitaria de Ciencias de la Salud-FUCS

مصطلحات موضوعية: Economics and Econometrics, ERBB-2 genes, breast cancer, transducción de señal, Materials Chemistry, Media Technology, genes ERBB-2, Forestry, cáncer de mama, growth factor receptor-bound protein 7 GRB7, signal transduction, proteína 7 unida al receptor del factor de crecimiento GRB7

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2990c0832f1c1fbf510f7f766f8145cTest
https://doi.org/10.31260/repertmedcir.01217372.1119Test

المؤلفون: Weiying Diao, Chenglong Ding, Boyang Yuan, Zan Li, Na Sun, Jiabin Huang

المصدر: Disease Markers. 2022:1-5

مصطلحات موضوعية: DNA (Cytosine-5-)-Methyltransferase 1, Lung Neoplasms, Article Subject, Receptor, ErbB-2, Biochemistry (medical), Clinical Biochemistry, General Medicine, Genes, erbB-2, Prognosis, Carcinoma, Non-Small-Cell Lung, Lymphatic Metastasis, Genetics, Humans, Molecular Biology

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931ac5c245cffb787593178c91d95bdTest
https://doi.org/10.1155/2022/8426384Test

المؤلفون: Fang Lu, Tingting Zhou, Yan Liu, Liying Song, Bin Zhang, Yuyan Li

المصدر: Contrast Media & Molecular Imaging. 2022:1-6

مصطلحات موضوعية: Microscopy, Fluorescence, Article Subject, Receptor, ErbB-2, Neoplasms, Humans, Radiology, Nuclear Medicine and imaging, Genes, erbB-2, In Situ Hybridization, Fluorescence

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0807e41dde840ce2039136badeac03Test
https://doi.org/10.1155/2022/3087681Test