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1دورية أكاديمية
المؤلفون: Vani Madhuri Velavalapalli, Venkatanarayana Chowdary Maddipati, Soňa Gurská, Narendran Annadurai, Barbora Lišková, Naresh Kumar Katari, Petr Džubák, Marián Hajdúch, Viswanath Das, Rambabu Gundla
مصطلحات موضوعية: Biochemistry, Genetics, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, without affecting lyn, molecular dynamics simulation, malignant fibroblast lines, bcr signaling pathway, based pharmacophore modeling, based focused library, 20 ns supported, displaying selective cytotoxicity, 9h b, 9g b, tyrosine kinase inhibitors, four new compounds, high ramos cells, tyrosine kinase, selective inhibition, new oxindole, particularly b, − 11, − 10, upstream proteins, study resulted, shows specificity
الإتاحة: https://doi.org/10.1021/acsomega.3c08343.s001Test
https://figshare.com/articles/journal_contribution/Novel_5_Substituted_Oxindole_Derivatives_as_Bruton_s_Tyrosine_Kinase_Inhibitors_Design_Synthesis_Docking_Molecular_Dynamics_Simulation_and_Biological_Evaluation/25164006Test -
2دورية أكاديمية
المؤلفون: Shravan Morla (6734402), Ongolu Ravikumar (14420439), Connor O’Hara (14420442), Rio Boothello (14420445), Alberto Vera (14420448), Elsamani I. Abdelfadiel (14420451), Rawan Fayyad (14420454), Daniel K. Afosah (3145332), Chetna Sharon (14420457), Leopoldo Fernandez (14420460), Syed Ammer Shah (14420463), Bhaumik B. Patel (1330791), Umesh R. Desai (299178)
مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Cancer, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sulfated glycosaminoglycan mimetics, sulfated gag mimetics, clinical utilized drugs, cancer stem cell, anionic sulfate groups, 46 μm ), synthetic mimetics thereof, engineering oral activity, ex vivo <, quaternary spheroid growth, vivo <, spheroid conditions, designing synthetic, oral delivery, oral administration, work presents, wide range, renewal factors, orally bioavailable, high number, gags ), focused library
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3دورية أكاديمية
المؤلفون: Markus Kraemer, Magali Bellion, Ann-Kathrin Kissmann, Tilmann Herberger, Christopher V. Synatschke, Anil Bozdogan, Jakob Andersson, Armando Rodriguez, Ludger Ständker, Sebastien Wiese, Steffen Stenger, Barbara Spellerberg, Kay-Eberhard Gottschalk, Ahmet Cetinkaya, Joanna Pietrasik, Tanja Weil, Frank Rosenau
المصدر: International Journal of Molecular Sciences; Volume 24; Issue 5; Pages: 4800
مصطلحات موضوعية: aptamer, focused library, antimicrobial peptide, next-generation wound dressing
جغرافية الموضوع: agris
وصف الملف: application/pdf
العلاقة: Materials Science; https://dx.doi.org/10.3390/ijms24054800Test
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4دورية أكاديمية
المؤلفون: Bharathikumar Vellalore Maruthachalam, Kris Barreto, Daniel Hogan, Anthony Kusalik, Clarence Ronald Geyer
المصدر: Frontiers in Microbiology, Vol 13 (2022)
مصطلحات موضوعية: phage display, synthetic antibody, focused library, long CDR library, next-generation sequencing, Notch signaling, Microbiology, QR1-502
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2022.931307/fullTest; https://doaj.org/toc/1664-302XTest
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5دورية أكاديمية
مصطلحات موضوعية: Enzyme design, De novo enzymes, Kemp elimination, Ancestral enzymes, Beta-lactamases, Focused library screening, Focused directed evolution
العلاقة: Gutierrez-Rus, L.I. [et al.]. Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme. Int. J. Mol. Sci. 2022, 23, 8934. [https://doi.org/10.3390/ijms23168934Test]; https://hdl.handle.net/10481/76988Test
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6دورية أكاديمية
المؤلفون: J. David Schnettler (14310745), Oskar James Klein (14310748), Tomasz S. Kaminski (1664377), Pierre-Yves Colin (1310004), Florian Hollfelder (426161)
مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Evolutionary Biology, Ecology, Computational Biology, Astronomical and Space Sciences not elsewhere classified, Physical Sciences not elsewhere classified, suffer suicide inhibition, requires bivalent cations, reached high efficiency, dynamic testing ground, devising new catalysts, covalent adduct rather, novel catalytic machineries, new catalytic motif, observing biocatalytic innovation, focused library approach, enhance mechanistic strategies, intermediate formation accelerated, increase p91 ’, hydrolyze phosphate triesters, 5 sup, throughput directed evolution, phosphate triesters, catalytic efficiencies, mechanistic solution, directed evolution, biocatalytic challenges, k <
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7دورية أكاديمية
المصدر: International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 8934
مصطلحات موضوعية: enzyme design, de novo enzymes, Kemp elimination, ancestral enzymes, β-lactamases, focused library screening, focused directed evolution
جغرافية الموضوع: agris
وصف الملف: application/pdf
العلاقة: Biochemistry; https://dx.doi.org/10.3390/ijms23168934Test
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8دورية أكاديمية
المصدر: Molecules; Volume 27; Issue 9; Pages: 2892
مصطلحات موضوعية: docking, drug discovery, enzyme inhibition, epigenetics, epi-informatics, focused library, molecular dynamics, multi-target epigenetic agent, polypharmacology, quinazoline
جغرافية الموضوع: agris
وصف الملف: application/pdf
العلاقة: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules27092892Test
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9دورية أكاديمية
المؤلفون: Carrasco, Kendall, Montersino, Camille, Derviaux, Carine, Saez-Ayala, Magali, Hoffer, Laurent, Restouin, Audrey, Castellano, Rémy, Casassa, Justine, Roche, Philippe, Pasquier, Eddy, Combes, Sébastien, Morelli, Xavier, Collette, Yves, Betzi, Stéphane
المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)
المصدر: ISSN: 0022-2623.
مصطلحات موضوعية: Bromodomain, protein-protein interaction, hit-to-lead, optimization, focused library, diversity-oriented library, drug discovery, BDII selective inhibitor, modulation, potentiation, bone-marrow-derived stromal cell conditioned medium, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35348328; hal-03624836; https://hal.science/hal-03624836Test; https://hal.science/hal-03624836/documentTest; https://hal.science/hal-03624836/file/Manuscript-Carrasco-et-al_revised-v3%287%29.pdfTest; PUBMED: 35348328
الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c02168Test
https://hal.science/hal-03624836Test
https://hal.science/hal-03624836/documentTest
https://hal.science/hal-03624836/file/Manuscript-Carrasco-et-al_revised-v3%287%29.pdfTest -
10دورية أكاديمية
المؤلفون: Pramod M. Sabale (5954882), Mateusz Imiołek (4786035), Pierre Raia (6243977), Sofia Barluenga (233807), Nicolas Winssinger (233808)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Cancer, Computational Biology, Chemical Sciences not elsewhere classified, synthetic library screening, pot ligation reaction, overcome major limitations, focused library targeting, staple peptides facilitates, enhanced peptide ligation, one hundred peptides, suprastapled peptides, peptide ’, peptide fragments, used directly, strategy leveraged, ppis ), mdm2 interaction, mdm2 immobilized, mass spectrometry, growing arsenal, combinatorially ligated, broadly embraced, best binders