نتائج البحث - "fluorescence-based assay"

1

دورية أكاديمية

The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2

المؤلفون: Bay, Yasmin, Egeberg Jeppesen, Mie, Frydenvang, Karla, Francotte, Pierre, Pirotte, Bernard, Pickering, Darryl S., Kristensen, Anders Skov, Kastrup, Jette Sandholm

المصدر: Bay , Y , Egeberg Jeppesen , M , Frydenvang , K , Francotte , P , Pirotte , B , Pickering , D S , Kristensen , A S & Kastrup , J S 2024 , ' The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2 ' , FEBS Letters , vol. 598 , no. 7 , pp. 743-757 . https://doi.org/10.1002/1873-3468.14824Test

مصطلحات موضوعية: BPAM344 binding mode, calcium-sensitive fluorescence-based assay, dimer interface, GluK2 mutations, positive allosteric modulation, X-ray crystallography

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/1873-3468.14824Test
https://curis.ku.dk/portal/da/publications/the-positive-allosteric-modulator-bpam344-and-lglutamate-introduce-an-activelike-structure-of-the-ligandbinding-domain-of-gluk2Test(edc0b943-651d-4436-ac37-82f7e06d37e7).html
https://curis.ku.dk/ws/files/387737935/FEBS_Letters_2024_Bay_The_positive_allosteric_modulator_BPAM344_and_L_glutamate_introduce_an_active_like_structure_of.pdfTest

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2

دورية أكاديمية

Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

المؤلفون: Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, De Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl, Frydenvang, Karla, Danober, Laurence, Skov Kristensen, Anders, Sandholm Kastrup, Jette, Pirotte, Bernard

المصدر: European Journal of Medicinal Chemistry, 264, 116036 (2023-12-09)

مصطلحات موضوعية: Ionotropic glutamate receptors Positive allosteric modulators thieno[3, 2-e]-1, 2, 4-thiadiazine 1, 1-dioxides 1, 4-Benzothiadiazine 1, 1-dioxides X-ray crystallography Calcium-sensitive fluorescence-based assay, Organic Chemistry, Drug Discovery, Pharmacology, General Medicine, Human health sciences, Pharmacy, pharmacology & toxicology, Physical, chemical, mathematical & earth Sciences, Chemistry, Sciences de la santé humaine, Pharmacie, pharmacologie & toxicologie, Physique, chimie, mathématiques & sciences de la terre, Chimie

العلاقة: https://api.elsevier.com/content/article/PII:S0223523423010036?httpAccept=text/xmlTest; urn:issn:0223-5234; urn:issn:1768-3254

الوصول الحر: https://orbi.uliege.be/handle/2268/312961Test

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3

دورية أكاديمية

Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes

المؤلفون: Sung Ho Lim, Seoungpyo Bae, Ho Seon Lee, Hyo-Kyung Han, Chang-Ik Choi

المصدر: Pharmaceuticals, Vol 16, Iss 9, p 1224 (2023)

مصطلحات موضوعية: Beta vulgaris L., betanin, cytochrome P450 enzymes, fluorescence-based assay, HepG2 cells, herb–drug interactions, Medicine, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1424-8247/16/9/1224Test; https://doaj.org/toc/1424-8247Test

الوصول الحر: https://doaj.org/article/4baf1b0e26664ed69a2a8327c9eee7a1Test

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النص الكامل

4

دورية أكاديمية

Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives

المؤلفون: Qiang Jin, JingJing Wu, Yue Wu, Hongxin Li, Moshe Finel, Dandan Wang, Guangbo Ge

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1068-1099 (2022)

مصطلحات موضوعية: Optical substrates, Drug-metabolizing enzymes (DMEs), Fluorescence-based assay, High-throughput screening, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211383522000223Test; https://doaj.org/toc/2211-3835Test

الوصول الحر: https://doaj.org/article/26af5e5a95de47ab88ef509d59f2b96fTest

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النص الكامل

5

دورية أكاديمية

Development of a Fluorescence-based Biosensor for Coumaphos

المؤلفون: Fabiana TORTORA, Elena PORZIO, Carmen GALOPPO, Ferdinando FEBBRAIO

المصدر: Sensors & Transducers, Vol 253, Iss 6, Pp 18-22 (2021)

مصطلحات موضوعية: helicase, pesticides, docking analysis, bioreceptor, biosensor, fluorescence-based assay, Technology (General), T1-995

وصف الملف: electronic resource

العلاقة: https://sensorsportal.com/HTML/DIGEST/november_2021/Vol_253/P_3239.pdfTest; https://doaj.org/toc/2306-8515Test; https://doaj.org/toc/1726-5479Test

الوصول الحر: https://doaj.org/article/d1349e51e791442ea468ffc4684ad1b8Test

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6

دورية أكاديمية

Recent Advances in Cancer Drug Discovery Through the Use of Phenotypic Reporter Systems, Connectivity Mapping, and Pooled CRISPR Screening

المؤلفون: Natasha Salame, Katharine Fooks, Nehme El-Hachem, Jean-Pierre Bikorimana, François E. Mercier, Moutih Rafei

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: HTS screening, fluorescence-based assay, immunomodulatory compounds, anti-cancer therapeutics, transcriptomics, CRISPR-Cas9, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2022.852143/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/48f3ff363b204134be5ee8b737670d67Test

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النص الكامل

7

دورية أكاديمية

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

المؤلفون: Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl S., Frydenvang, Karla, Danober, Laurence, Kristensen, Anders Skov, Kastrup, Jette Sandholm, Pirotte, Bernard

المصدر: Francotte , P , Bay , Y , Goffin , E , Colson , T , Lesenfants , C , Dorosz , J , Laulumaa , S , Fraikin , P , de Tullio , P , Beaufour , C , Botez , I , Pickering , D S , Frydenvang , K , Danober , L , Kristensen , A S , Kastrup , J S & Pirotte , B 2024 , ' Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators ' , ....

مصطلحات موضوعية: 1,2,4-Benzothiadiazine 1,1-dioxides, Calcium-sensitive fluorescence-based assay, Ionotropic glutamate receptors, Positive allosteric modulators, thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxides, X-ray crystallography

الإتاحة: https://doi.org/10.1016/j.ejmech.2023.116036Test
https://curis.ku.dk/portal/da/publications/exploring-thienothiadiazine-dioxides-as-isosteric-analogues-of-benzo-and-pyridothiadiazine-dioxides-in-the-search-of-new-ampa-and-kainate-receptor-positive-allosteric-modulatorsTest(4ff101cd-50ac-44e4-8b8c-dfcfe8ce4852).html

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