دورية أكاديمية
Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis
| العنوان: | Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis |
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| المؤلفون: | Shunya Nakane, Haruki Koike, Tomohiro Hayashi, Yuji Nakatsuji |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 4, p 2296 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | ganglionic acetylcholine receptor, autoantibodies, autoimmune autonomic ganglionopathy, extra-autonomic manifestations, immunotherapy, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Autoimmune autonomic ganglionopathy (AAG) is a disease of autonomic failure caused by ganglionic acetylcholine receptor (gAChR) autoantibodies. Although the detection of autoantibodies is important for distinguishing the disease from other neuropathies that present with autonomic dysfunction, other factors are important for accurate diagnosis. Here, we provide a comprehensive review of the clinical features of AAG, highlighting differences in clinical course, clinical presentation, and laboratory findings from other neuropathies presenting with autonomic symptoms. The first step in diagnosing AAG is careful history taking, which should reveal whether the mode of onset is acute or chronic, followed by an examination of the time course of disease progression, including the presentation of autonomic and extra-autonomic symptoms. AAG is a neuropathy that should be differentiated from other neuropathies when the patient presents with autonomic dysfunction. Immune-mediated neuropathies, such as acute autonomic sensory neuropathy, are sometimes difficult to differentiate, and therefore, differences in clinical and laboratory findings should be well understood. Other non-neuropathic conditions, such as postural orthostatic tachycardia syndrome, chronic fatigue syndrome, and long COVID, also present with symptoms similar to those of AAG. Although often challenging, efforts should be made to differentiate among the disease candidates. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/4/2296Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25042296 |
| الوصول الحر: | https://doaj.org/article/019d8b6fe53c4849948c81a920014802Test |
| رقم الانضمام: | edsdoj.019d8b6fe53c4849948c81a920014802 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25042296 |