نتائج البحث - "evolutionary action"

المساهمون: Biological and Environmental Science and Engineering (BESE) Division, Bioscience Program, Laboratory of DNA Replication and Recombination, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, United States, Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States, Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, United States

مصطلحات موضوعية: Transcription, Nucleotide excision repair, protein structure, Replication Forks, Vus, Cancer Mutations, Evolutionary Action, Helicase-nuclease

وصف الملف: application/pdf

العلاقة: https://www.frontiersin.org/articles/10.3389/fmolb.2021.791792/fullTest; Tsutakawa, S. E., Bacolla, A., Katsonis, P., Bralić, A., Hamdan, S. M., Lichtarge, O., … Tsai, C.-L. (2021). Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication. Frontiers in Molecular Biosciences, 8. doi:10.3389/fmolb.2021.791792; 2-s2.0-85121787000; Frontiers in molecular biosciences; PMC8710748; http://hdl.handle.net/10754/675064Test

الإتاحة: https://doi.org/10.3389/fmolb.2021.791792Test
http://hdl.handle.net/10754/675064Test

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النص الكامل

4

دورية أكاديمية

Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication

المؤلفون: Susan E. Tsutakawa, Albino Bacolla, Panagiotis Katsonis, Amer Bralić, Samir M. Hamdan, Olivier Lichtarge, John A. Tainer, Chi-Lin Tsai

المصدر: Frontiers in Molecular Biosciences, Vol 8 (2021)

مصطلحات موضوعية: protein structure, evolutionary action, VUS, cancer mutations, helicase-nuclease, transcription, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmolb.2021.791792/fullTest; https://doaj.org/toc/2296-889XTest

الوصول الحر: https://doaj.org/article/ad91801f67d54b42bcc420e45cea724eTest

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النص الكامل

5

دورية أكاديمية

Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase

المؤلفون: Cea-Rama, Isabel, Coscolín, Cristina, Katsonis, Pangiotis, Bargiela, Rafael, Golyshin, Peter, Lichtarge, Olivier, Ferrer, Manuel, Sanz-Aparicio, Julia

المصدر: Cea-Rama , I , Coscolín , C , Katsonis , P , Bargiela , R , Golyshin , P , Lichtarge , O , Ferrer , M & Sanz-Aparicio , J 2021 , ' Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase ' , Computational and Structural Biotechnology Journal , vol. 19 , pp. 2307-2317 . https://doi.org/10.1016/j.csbj.2021.04.041Test

مصطلحات موضوعية: Crystal structure, EA, evolutionary action, ET, evolutionary trace, Eapp, apparent enantioselectivity, Esterase, HEPES, 40 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, Ni-NTA, nickel-nitrilotriacetic acid, Promiscuity, Protein engineering, Specificity