المؤلفون: Almaliti, Jehad, Fajtová, Pavla, Calla, Jaeson, LaMonte, Gregory M, Feng, Mudong, Rocamora, Frances, Ottilie, Sabine, Glukhov, Evgenia, Boura, Evzen, Suhandynata, Raymond T, Momper, Jeremiah D, Gilson, Michael K, Winzeler, Elizabeth A, Gerwick, William H, O'Donoghue, Anthony J

المصدر: Chemistry - A European Journal. 29(20)

مصطلحات موضوعية: Chemical Sciences, Orphan Drug, Rare Diseases, Vector-Borne Diseases, Infectious Diseases, Malaria, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Mice, Animals, Humans, Proteasome Inhibitors, Proteasome Endopeptidase Complex, Plasmodium, Plasmodium falciparum, Antimalarials, epoxyketone, inhibition, malaria, plasmodium, proteasome, General Chemistry, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6x99c667Test

المؤلفون: Jalovecka, Marie, Hartmann, David, Miyamoto, Yukiko, Eckmann, Lars, Hajdusek, Ondrej, O'Donoghue, Anthony J, Sojka, Daniel

المصدر: International Journal for Parasitology Drugs and Drug Resistance. 8(3)

مصطلحات موضوعية: Microbiology, Biological Sciences, Rare Diseases, Orphan Drug, Emerging Infectious Diseases, Vector-Borne Diseases, Biotechnology, Malaria, Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Babesia, Babesia microti, Babesiosis, Boronic Acids, Cell Line, Disease Models, Animal, Drug Delivery Systems, Female, Macrophages, Mice, Oligopeptides, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Proteome, Proteasome, Carfilzomib, Epoxyketone, Cytotoxicity, Medical Microbiology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6rv665g4Test

المؤلفون: Jehad Almaliti, Pavla Fajtová, Jaeson Calla, Gregory M. LaMonte, Mudong Feng, Frances Rocamora, Sabine Ottilie, Evgenia Glukhov, Evzen Boura, Raymond T. Suhandynata, Jeremiah D. Momper, Michael K. Gilson, Elizabeth A. Winzeler, William H. Gerwick, Anthony J. O'Donoghue

مصطلحات موضوعية: Epoxyketone, Inhibition, Plasmodium, Proteasome, Malaria

العلاقة: info:eu-repo/grantAgreement/EC/H2020/846688/; https://zenodo.org/record/7655290Test; https://doi.org/10.1002/chem.202203958Test; oai:zenodo.org:7655290

الإتاحة: https://doi.org/10.1002/chem.202203958Test
https://zenodo.org/record/7655290Test

المؤلفون: Bruna Domingues Vieira, Henrique Niero, Rafael de Felício, Luiz Fernando Giolo Alves, Cristina Freitas Bazzano, Renata Sigrist, Luciana Costa Furtado, Gabriela Felix Persinoti, Leticia Veras Costa-Lotufo, Daniela Barretto Barbosa Trivella

المصدر: Frontiers in Microbiology, Vol 13 (2022)

مصطلحات موضوعية: Streptomyces sp. BRA-346, epoxyketone peptides, proteasome inhibitors, genome mining, biosynthesis of natural products, transformation-associated recombination cloning, Microbiology, QR1-502

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2022.786008/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/61a5956fa2dc49d9ab7ae42ab531b604Test

المؤلفون: Jehad Almaliti, Muhammed Alzweiri, Momen Alhindy, Tamam Al-Helo, Ibrahim Daoud, Raghad Deknash, C. Benjamin Naman, Bashaer Abu-Irmaileh, Yasser Bustanji, Islam Hamad

المصدر: Molecules; Volume 27; Issue 7; Pages: 2261

مصطلحات موضوعية: lipase inhibitors, novel warhead, epoxyketone, dyslipidemia, obesity, peptide inhibitors

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: https://dx.doi.org/10.3390/molecules27072261Test

الإتاحة: https://doi.org/10.3390/molecules27072261Test

المؤلفون: Yuting Gao (8108615), Guixian Zhao (11857613), Pengyang He (11857616), Gong Zhang (69122), Yangfeng Li (8107268), Yizhou Li (226344)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Pharmacology, Ecology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, numerous chemical members, epoxides widely exist, encoded chemical libraries, broad substrate scope, also successfully explored, abundant building blocks, high structural diversity, fully leverage α, structural diversification, powerful platform, implementing aldehydes, excellent conversions, epoxyketone moiety, drug discovery, compatible synthesis, clinical candidates, chlorinated ketones, approved drugs

العلاقة: https://figshare.com/articles/journal_contribution/DNA-Compatible_Synthesis_of_-Epoxyketones_for_DNA-Encoded_Chemical_Libraries/17296154Test

الإتاحة: https://doi.org/10.1021/acs.bioconjchem.1c00567.s001Test

المؤلفون: Carmony, Kimberly, Lee, Wooin, Kim, Kyung Bo

المساهمون: 이우인, 김경보

مصطلحات موضوعية: drug design, epoxyketone, oprozomib, proteasome inhibitors, proteasome structures

العلاقة: CHEMBIOCHEM Vol.17 No.22, pp. 2115-2117; http://hdl.handle.net/10371/117528Test

الإتاحة: https://doi.org/10.1002/cbic.201600488Test
http://hdl.handle.net/10371/117528Test

المؤلفون: Bruna Domingues Vieira, Henrique Niero, Rafael de Felício, Luiz Fernando Giolo Alves, Cristina Freitas Bazzano, Renata Sigrist, Luciana Costa Furtado, Gabriela Felix Persinoti, Leticia Veras Costa-Lotufo, Daniela Barretto Barbosa Trivella

مصطلحات موضوعية: Microbiology, Microbial Genetics, Microbial Ecology, Mycology, Streptomyces sp. BRA-346, epoxyketone peptides, proteasome inhibitors, genome mining, biosynthesis of natural products, transformation-associated recombination cloning, mass spectrometry, molecular networking

العلاقة: https://figshare.com/articles/dataset/Data_Sheet_1_Production_of_Epoxyketone_Peptide-Based_Proteasome_Inhibitors_by_Streptomyces_sp_BRA-346_Regulation_and_Biosynthesis_docx/19411301Test

الإتاحة: https://doi.org/10.3389/fmicb.2022.786008.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Production_of_Epoxyketone_Peptide-Based_Proteasome_Inhibitors_by_Streptomyces_sp_BRA-346_Regulation_and_Biosynthesis_docx/19411301Test

المؤلفون: Henneberg, Fabian

مرشدي الرسالة: Stark, Holger Prof. Dr.

مصطلحات موضوعية: 572, 20S proteasome, 26S proteasome, X-ray crystallography, 20S inhibition, Electron cryo-microscopy, Epoxyketone, Biologie (PPN619462639)

العلاقة: http://creativecommons.org/licenses/by-nc-nd/4.0Test/

الإتاحة: http://hdl.handle.net/11858/00-1735-0000-002E-E61E-2Test

المؤلفون: Yukiko Miyamoto, Anthony J. O’Donoghue, Marie Jalovecka, Lars Eckmann, Daniel Sojka, Ondrej Hajdusek, David Hartmann

المصدر: International journal for parasitology. Drugs and drug resistance, vol 8, iss 3
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 394-402 (2018)

مصطلحات موضوعية: 0301 basic medicine, Proteome, animal diseases, Cytotoxicity, Pharmacology, Epoxyketone, Ixazomib, chemistry.chemical_compound, Mice, Drug Delivery Systems, Pharmacology (medical), Babesia divergens, biology, Bortezomib, Babesiosis, Boronic Acids, 3. Good health, Infectious Diseases, 5.1 Pharmaceuticals, Medical Microbiology, Female, Development of treatments and therapeutic interventions, Infection, Oligopeptides, Proteasome Inhibitors, medicine.drug, Biotechnology, Proteasome Endopeptidase Complex, 030106 microbiology, Babesia, Babesia microti, Article, lcsh:Infectious and parasitic diseases, Cell Line, 03 medical and health sciences, Epoxomicin, Rare Diseases, In vivo, parasitic diseases, medicine, Animals, lcsh:RC109-216, Proteasome, Animal, Macrophages, Carfilzomib, biology.organism_classification, medicine.disease, Malaria, Vector-Borne Diseases, Disease Models, Animal, 030104 developmental biology, Emerging Infectious Diseases, Orphan Drug, Good Health and Well Being, chemistry, Disease Models, Parasitology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5623ae688ad837b496a820bfaf98e7Test
https://escholarship.org/uc/item/6rv665g4Test