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1دورية أكاديمية
المؤلفون: A.L. Martínez, J. Brea, D. López, N. Cosme, M. Barro, X. Monroy, J. Burgueño, M. Merlos, M.I. Loza
المصدر: Pharmacological Research, Vol 202, Iss , Pp 107111- (2024)
مصطلحات موضوعية: Phenotypic screening, Immortalized cell lines, In vitro models, Neuropathic pain, In vitro pharmacology, Early drug discovery, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S1043661824000550Test; https://doaj.org/toc/1096-1186Test
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2دورية أكاديمية
المؤلفون: Keheng Wu, Xue Li, Zhou Zhou, Youni Zhao, Mei Su, Zhuo Cheng, Xinyi Wu, Zhijun Huang, Xiong Jin, Jingxi Li, Mengjun Zhang, Jack Liu, Bo Liu
المصدر: Frontiers in Pharmacology, Vol 15 (2024)
مصطلحات موضوعية: artificial intelligence (AI), machine learning (ML), early drug discovery, PBPK modeling, PD modeling, P-CABs, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2024.1330855/fullTest; https://doaj.org/toc/1663-9812Test
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3دورية أكاديمية
المؤلفون: Emile P. Chen, Shayoni Dutta, Ming-Hsun Ho, Michael P. DeMartino
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Immunology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, screening criteria must, machine learning approach, adme space early, preclinical efficacy models, achieve therapeutic efficacy, pk end points, define pk drivers, pd relationships presented, based virtual pk, based virtual exploration, early drug discovery, specific pk drivers, identify target pharmacology, pd exploration, driving efficacy, based analysis, multiple pharmacology, downstream pharmacology, corresponding pharmacology, results demonstrate
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c02169.s001Test
https://figshare.com/articles/journal_contribution/Model-Based_Virtual_PK_PD_Exploration_and_Machine_Learning_Approach_to_Define_PK_Drivers_in_Early_Drug_Discovery/25249732Test -
4دورية أكاديمية
المؤلفون: François Sindt, Anthony Seyller, Merveille Eguida, Didier Rognan
مصطلحات موضوعية: Biophysics, Biochemistry, Neuroscience, Pharmacology, Biotechnology, Inorganic Chemistry, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sized chemical spaces, revolutionizing hit identification, estrogen β receptor, either known ligands, driven ligand design, directly connected according, commercial chemical reagents, chemically novel candidates, chemical spaces cannot, bespoke chemical spaces, quickly enumerate hits, early drug discovery, hoc computational tools, based organic chemistry, organic chemistry, enumerate drug, based approach, computational resources, computational method, vitro <
الإتاحة: https://doi.org/10.1021/acscentsci.3c01521.s002Test
https://figshare.com/articles/journal_contribution/Protein_Structure-Based_Organic_Chemistry-Driven_Ligand_Design_from_Ultralarge_Chemical_Spaces/25211279Test -
5
المؤلفون: Ermondi, Giuseppe, Jimenez, Diego Garcia, Sebastiano, Matteo Rossi, Kihlberg, Jan, Caron, Giulia
المصدر: Pharmaceutics. 15(1)
مصطلحات موضوعية: bRo5, conformational sampling, early drug discovery, molecular chameleon, NMR, PROTAC
وصف الملف: electronic
الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497728Test
https://doi.org/10.3390/pharmaceutics15010272Test
https://uu.diva-portal.org/smash/get/diva2:1741717/FULLTEXT01.pdfTest -
6دورية أكاديمية
المؤلفون: Giuseppe Ermondi, Diego Garcia Jimenez, Matteo Rossi Sebastiano, Jan Kihlberg, Giulia Caron
المصدر: Pharmaceutics; Volume 15; Issue 1; Pages: 272
مصطلحات موضوعية: bRo5, conformational sampling, early drug discovery, molecular chameleon, NMR, PROTAC
وصف الملف: application/pdf
العلاقة: Pharmacokinetics and Pharmacodynamics; https://dx.doi.org/10.3390/pharmaceutics15010272Test
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7
المؤلفون: Keheng Wu, Xue Li, Zhou Zhou, Youni Zhao, Mei Su, Zhuo Cheng, Xinyi Wu, Zhijun Huang, Xiong Jin, Jingxi Li, Mengjun Zhang, Jack Liu, Bo Liu
مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, artificial intelligence (AI), machine learning (ML), early drug discovery, PBPK modeling, PD modeling, P-CABs
الإتاحة: https://doi.org/10.3389/fphar.2024.1330855.s001Test
https://figshare.com/articles/dataset/Table1_Predicting_pharmacodynamic_effects_through_early_drug_discovery_with_artificial_intelligence-physiologically_based_pharmacokinetic_AI-PBPK_modelling_DOCX/25231112Test -
8كتاب
المؤلفون: Liu, Xiaosong
المصدر: Liu , X 2021 , ' Implementation of structural bioinformatics in thromboinflammation studies ' , Maastricht University , Maastricht . https://doi.org/10.26481/dis.20211209xlTest
مصطلحات موضوعية: structure bioinformatics, protein structure, thromboinflammation, early drug discovery
وصف الملف: application/pdf; image/jpeg
العلاقة: https://cris.maastrichtuniversity.nl/en/publications/2d242729-540a-4854-8b73-6177370040f2Test; urn:ISBN:9789464169119
الإتاحة: https://doi.org/10.26481/dis.20211209xlTest
https://cris.maastrichtuniversity.nl/en/publications/2d242729-540a-4854-8b73-6177370040f2Test
https://cris.maastrichtuniversity.nl/ws/files/75267651/c7297_embargo.pdfTest
https://cris.maastrichtuniversity.nl/ws/files/75267653/s7297.pdfTest
https://cris.maastrichtuniversity.nl/ws/files/75267655/p7297.pdfTest
https://cris.maastrichtuniversity.nl/ws/files/75267657/k7297.jpgTest
https://cris.maastrichtuniversity.nl/ws/files/75267659/i7297.pdfTest -
9دورية أكاديمية
المؤلفون: Iñigo Ayestaran, Ana Galhoz, Elmar Spiegel, Ben Sidders, Jonathan R. Dry, Frank Dondelinger, Andreas Bender, Ultan McDermott, Francesco Iorio, Michael P. Menden
المصدر: Patterns, Vol 1, Iss 5, Pp 100065- (2020)
مصطلحات موضوعية: precision medicine, cancer, drug resistance, early drug discovery, biostatistics, biomarker discovery, Computer software, QA76.75-76.765
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2666389920300854Test; https://doaj.org/toc/2666-3899Test
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10دورية أكاديمية
المؤلفون: Ayestaran, I., Galhoz, A., Spiegel, E, Sidders, B., Dry, J.R., Dondelinger, F., Bender, A., McDermott, U., Iorio, F., Menden, M.
المصدر: Patterns 1:100065 (2020)
مصطلحات موضوعية: precision medicine, cancer, drug resistance, early drug discovery, biostatistics, biomarker discovery, drug high-throughput screens, cancer cell lines, CRISPR, drug combinations
وصف الملف: application/pdf
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33205120; info:eu-repo/semantics/altIdentifier/isbn/2666-3899; info:eu-repo/semantics/altIdentifier/eissn/2666-3899; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60491Test; urn:isbn:2666-3899; urn:issn:2666-3899
الإتاحة: https://doi.org/10.1016/j.patter.2020.100065Test
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60491Test