المؤلفون: KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking

المصدر: eLife, Vol 13 (2024)

مصطلحات موضوعية: HIV-1, capsid, drug mechanism of action, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://elifesciences.org/articles/83605Test; https://doaj.org/toc/2050-084XTest

الوصول الحر: https://doaj.org/article/08ba42401fe84baebde255dedc84b832Test

المؤلفون: Faysal, KM Rifat, Walsh, James C, Renner, Nadine, Márquez, Chantal L, Shah, Vaibhav B, Tuckwell, Andrew J, Christie, Michelle P, Parker, Michael W, Turville, Stuart G, Towers, Greg J, James, Leo C, Jacques, David A, Böcking, Till

المصدر: Elife , 13 , Article e83605. (2024)

مصطلحات موضوعية: HIV-1, capsid, drug mechanism of action, infectious disease, microbiology, molecular biophysics, none, structural biology

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10187888/1/elife-83605-v1.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10187888Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10187888/1/elife-83605-v1.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10187888Test/

المؤلفون: Vijay Soni, Zhe Wang, Vinayak Singh

المصدر: Frontiers in Microbiology, Vol 14 (2023)

مصطلحات موضوعية: antimicrobial resistance (AMR), drug mechanism of action, LC-MS, metabolomic biomarker, microbial metabolomics, novel drug candidates, Microbiology, QR1-502

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fmicb.2023.1222594/fullTest; https://doaj.org/toc/1664-302XTest

الوصول الحر: https://doaj.org/article/a665ddff04824eb086af19a65bd1a1ceTest

المؤلفون: Paolo Montuschi, Irfan Rahman

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: respiratory pharmachology, personalised pharmacotherapy, personalised medicine, drug mechanism of action, pharmacological targets, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2022.1052994/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/196079f5988241079177538de8228557Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S

المصدر: Molecular Cell. 68(1)

مصطلحات موضوعية: Biological Sciences, Biotechnology, Human Genome, Genetics, Orphan Drug, Cancer, Rare Diseases, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Antineoplastic Agents, CRISPR-Cas Systems, Colchicine, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Genetic Testing, Genetic Vectors, Glycine, HeLa Cells, Humans, K562 Cells, Kinesins, Lentivirus, Microtubules, Mutation, Myelodysplastic Syndromes, RNA, Guide, Kinetoplastida, Recombinant Fusion Proteins, Small Molecule Libraries, Sulfones, Tubulin, Tubulin Modulators, Vinblastine, Hela Cells, CRISPRa, CRISPRi, chemical genetics, drug mechanism of action, drug target identification, genome-wide CRISPR screening, microtubules, rigosertib, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1d37n4k6Test

المؤلفون: Bresso, Emmanuel, Monnin, Pierre, Bousquet, Cédric, Calvier, François-Elie, Ndiaye, Ndeye-Coumba, Petitpain, Nadine, Smaïl-Tabbone, Malika, Coulet, Adrien

المساهمون: Computational Algorithms for Protein Structures and Interactions (CAPSID), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Complex Systems, Artificial Intelligence & Robotics (LORIA - AIS), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Knowledge representation, reasonning (ORPAILLEUR), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Orange Labs, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Régional de PharmacoVigilance de Lorraine (CRPV Lorraine), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), ANR-15-CE23-0028,PractiKPharma,Confrontation entre connaissances de l'état de l'art et connaissances extraites de dossiers patients en pharmacogénomique(2015), ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015)

المصدر: ISSN: 1472-6947.

مصطلحات موضوعية: Adverse drug reaction, Explainable AI, Knowledge graph, Drug mechanism of action, [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34039343; hal-03240476; https://inria.hal.science/hal-03240476Test; https://inria.hal.science/hal-03240476/documentTest; https://inria.hal.science/hal-03240476/file/s12911-021-01518-6.pdfTest; PUBMED: 34039343; PUBMEDCENTRAL: PMC8157660

الإتاحة: https://doi.org/10.1186/s12911-021-01518-6Test
https://inria.hal.science/hal-03240476Test
https://inria.hal.science/hal-03240476/documentTest
https://inria.hal.science/hal-03240476/file/s12911-021-01518-6.pdfTest

المؤلفون: Libardo, M. Daben J, Duncombe, Caroline J., Green, Simon R., Wyatt, Paul G., Thompson, Stephen, Ray, Peter C., Ioerger, Thomas R., Oh, Sangmi, Goodwin, Michael B., Boshoff, Helena I. M., Barry III, Clifton E.

المصدر: Libardo , M D J , Duncombe , C J , Green , S R , Wyatt , P G , Thompson , S , Ray , P C , Ioerger , T R , Oh , S , Goodwin , M B , Boshoff , H I M & Barry III , C E 2021 , ' Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis ' , Cell Chemical Biology , vol. 28 , no. 8 , pp. 1180-1191.e20 . https://doi.org/10.1016/j.chembiol.2021.02.023Test

مصطلحات موضوعية: tuberculosis, drug mechanism of action, pro-drug, tryptophan metabolism, antimetabolite, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1308, name=Clinical Biochemistry, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/0a2339ec-4429-49c5-a052-1a47caae007dTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2021.02.023Test
https://discovery.dundee.ac.uk/en/publications/0a2339ec-4429-49c5-a052-1a47caae007dTest
https://discovery.dundee.ac.uk/ws/files/57600215/1_s2.0_S2451945621001082_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85112587717&partnerID=8YFLogxKTest

المؤلفون: C. P. Ilo, S. N. Omenyi, I. O. Ani

المصدر: UNIZIK Journal of Engineering and Applied Sciences; Vol. 19 No. 1 (2021): Journal of Engineering and Applied Sciences; 615 - 624

مصطلحات موضوعية: Human immunodeficiency virus, Drug mechanism of action, Interfacial energetics, Hamaker constant

وصف الملف: application/pdf

العلاقة: https://journals.unizik.edu.ng/index.php/ujeas/article/view/1810/1469Test; https://journals.unizik.edu.ng/index.php/ujeas/article/view/1810Test

الإتاحة: https://journals.unizik.edu.ng/index.php/ujeas/article/view/1810Test

المؤلفون: Maria Dalla Pozza, Christophe Orvain, Leonardo Brustolin, Nicolò Pettenuzzo, Chiara Nardon, Christian Gaiddon, Dolores Fregona

المصدر: Molecules; Volume 26; Issue 13; Pages: 4073

مصطلحات موضوعية: gastric cancer, metal complexes, chemotherapy, dithiocarbamates, drug mechanism of action, ER stress, p53, autophagy

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules26134073Test

الإتاحة: https://doi.org/10.3390/molecules26134073Test

المؤلفون: Dalla Pozza, Maria, Orvain, Christophe, Brustolin, Leonardo, Pettenuzzo, Nicolò, Nardon, Chiara, Gaiddon, Christian, Fregona, Dolores

المساهمون: Università degli Studi di Padova = University of Padua (Unipd), Interface de Recherche Fondamentale et Appliquée en Cancérologie (IRFAC - Inserm U1113), Centre Paul Strauss (CRLCC Paul Strauss), UNICANCER-UNICANCER-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération de Médecine Translationelle de Strasbourg (FMTS)

المصدر: ISSN: 1420-3049 ; Molecules ; https://hal.science/hal-03450763Test ; Molecules, 2021, 26 (13), pp.4073. ⟨10.3390/molecules26134073⟩.

مصطلحات موضوعية: ER stress, autophagy, chemotherapy, dithiocarbamates, drug mechanism of action, gastric cancer, metal complexes, p53, MESH: Adenocarcinoma, MESH: Antineoplastic Agents, MESH: Cell Proliferation, MESH: Coordination Complexes, MESH: Gold, MESH: Humans, MESH: Ruthenium, MESH: Stomach Neoplasms, MESH: Thiocarbamates, MESH: Tumor Cells, Cultured, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34279414; hal-03450763; https://hal.science/hal-03450763Test; https://hal.science/hal-03450763/documentTest; https://hal.science/hal-03450763/file/molecules-26-04073-v2.pdfTest; PUBMED: 34279414; PUBMEDCENTRAL: PMC8271683

الإتاحة: https://doi.org/10.3390/molecules26134073Test
https://hal.science/hal-03450763Test
https://hal.science/hal-03450763/documentTest
https://hal.science/hal-03450763/file/molecules-26-04073-v2.pdfTest