المؤلفون: Anke Van der Perren, Veerle Baekelandt, Björn H. Falkenburger, Lennart Höfs, Chris Van Den Haute, Eva M. Szegö

المصدر: Experimental neurology 347, 113900 (2022). doi:10.1016/j.expneurol.2021.113900

مصطلحات موضوعية: Male, pathology [Dopaminergic Neurons], Parkinson's disease, drug effects [Dopaminergic Neurons], Striatum, physiology [Oxidative Stress], biosynthesis [rab7 GTP-Binding Proteins], medicine.disease_cause, Mice, chemistry.chemical_compound, Rab7, metabolism [Reactive Oxygen Species], Axon, Cells, Cultured, pharmacology [rab7 GTP-Binding Proteins], metabolism [Dopaminergic Neurons], Neurodegeneration, Dopaminergic, Neuroprotection, physiology [DNA Damage], Cell biology, medicine.anatomical_structure, Neurology, drug effects [DNA Damage], alpha-Synuclein, drug effects [Oxidative Stress], Female, Protein aggregation, Neurite, toxicity [alpha-Synuclein], Developmental Neuroscience, medicine, Autophagy, Animals, Humans, ddc:610, biosynthesis [alpha-Synuclein], Rats, Wistar, Alpha-synuclein, Dopaminergic Neurons, rab7 GTP-Binding Proteins, medicine.disease, Rats, Mice, Inbred C57BL, Oxidative Stress, chemistry, Oxidative stress, DNA damage, Reactive Oxygen Species, DNA Damage

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05b397acfc3516ae9446415578af5ecTest

المؤلفون: Yujia Zhao, Yuze Qi, Qingru Li, Huihui Quan, Dan Liu, Hui Zhou

المصدر: Neuroscience letters 771, 136471 (2022). doi:10.1016/j.neulet.2022.136471

مصطلحات موضوعية: Male, Lipopolysaccharides, metabolism [Nerve Growth Factors], metabolism [Parkinson Disease], drug effects [Dopaminergic Neurons], Lipopolysaccharide, metabolism [Microglia], drug effects [Microglia], Connexins, Mice, toxicity [Lipopolysaccharides], Animals, Connexin43, ddc:610, Nerve Growth Factors, therapeutic use [Oligopeptides], Inflammation, Cell Death, General Neuroscience, Dopaminergic Neurons, metabolism [Dopaminergic Neurons], pharmacology [Oligopeptides], Parkinson Disease, pharmacology [Connexins], metabolism [Connexin 43], drug therapy [Parkinson Disease], gap 27 peptide, Mice, Inbred C57BL, Astrocytes, Connexin 43, antagonists & inhibitors [Connexin 43], Parkinson’s disease, therapeutic use [Connexins], etiology [Parkinson Disease], Microglia, Oligopeptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5747b2eb7ca27f8960d4853cef325aeTest
https://pub.dzne.de/record/163619Test

المؤلفون: Pingping Song, Lena F. Burbulla, Dimitri Krainc, Jianbin Zheng, Michaela E. Johnson, Weilan Jiang, Patrik Brundin

المصدر: JCI insight 6(19), e148649 (2021). doi:10.1172/jci.insight.148649
JCI Insight

مصطلحات موضوعية: drug effects [Glucosylceramidase], Parkinson's disease, Drug Evaluation, Preclinical, pharmacology [Antipsychotic Agents], drug effects [Dopaminergic Neurons], Pharmacology, genetics [Glucosylceramidase], Mice, genetics [Parkinson Disease], metabolism [alpha-Synuclein], Drug screens, drug effects [Induced Pluripotent Stem Cells], Chemistry, metabolism [Dopaminergic Neurons], Dopaminergic, Neurodegeneration, Parkinson Disease, General Medicine, LRRK2, metabolism [Induced Pluripotent Stem Cells], Parkinson disease, genetics [Parkinsonian Disorders], physiopathology [Parkinsonian Disorders], alpha-Synuclein, Glucosylceramidase, physiopathology [Parkinson Disease], drug effects [alpha-Synuclein], Research Article, Antipsychotic Agents, medicine.drug, pharmacology [Quetiapine Fumarate], Induced Pluripotent Stem Cells, metabolism [Parkinson Disease], metabolism [Parkinsonian Disorders], Glucosylceramides, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Quetiapine Fumarate, Parkinsonian Disorders, Dopamine, metabolism [Glucosylceramides], medicine, Animals, Humans, ddc:610, Dopaminergic Neurons, Drug Repositioning, medicine.disease, Symptomatic relief, Quetiapine, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], Glucocerebrosidase, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e57b68f83b8651105ddd9418b71ddTest
https://doi.org/10.1172/jci.insight.148649Test

المؤلفون: Günter U. Höglinger, Wolfgang Wurst, Matthias Höllerhage, Natascha Fussi, Christian Behrends, Thomas W. Rösler

المصدر: Neuropharmacology 149, 13-26 (2019). doi:10.1016/j.neuropharm.2019.01.023

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Druggability, drug effects [Dopaminergic Neurons], pharmacology [Pyrimidines], chemistry.chemical_compound, 0302 clinical medicine, metabolism [alpha-Synuclein], pharmacology [Furans], Caspase 7, Diphosphonates, Caspase 3, pharmacology [Diphosphonates], Benzenesulfonates, Dopaminergic, Parkinson Disease, Neuroprotection, Cell biology, MAP1LC3B protein, human, Toxicity, alpha-Synuclein, 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate), Signal transduction, Microtubule-Associated Proteins, drug effects [alpha-Synuclein], Signal Transduction, Cell Survival, drug effects [Cell Survival], PI103, drug effects [Autophagy], metabolism [Parkinson Disease], Cell Line, 03 medical and health sciences, Cellular and Molecular Neuroscience, Autophagy, metabolism [Caspase 3], Humans, ddc:610, metabolism [Caspase 7], Furans, pharmacology [Benzenesulfonates], Pharmacology, Alpha-synuclein, Synucleinopathies, Dopaminergic Neurons, metabolism [Microtubule-Associated Proteins], pharmacology [Pyridines], drug therapy [Parkinson Disease], L 690330, Pyrimidines, 030104 developmental biology, nervous system, chemistry, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e929d4d566ceb29c99157505daf15Test
https://doi.org/10.1016/j.neuropharm.2019.01.023Test

المؤلفون: Paul C. Keane, Christopher Morris, P.J. Kahle, Peter S. Hanson, Fiona E. N. LeBeau, Ahmad Khundakar, Peter G. Blain, Sarah J. Judge, Philippa D. Hepplewhite, Lina Patterson

المصدر: Neuroscience letters 711, 134437 (2019). doi:10.1016/j.neulet.2019.134437
Neuroscience Letters

مصطلحات موضوعية: 0301 basic medicine, Male, Parkinson's disease, pathology [Dopaminergic Neurons], drug effects [Dopaminergic Neurons], toxicity [Trichloroethylene], TaClo, pathology [Parkinsonian Disorders], toxicity [Neurotoxins], CE, coefficient of error, Mice, 0302 clinical medicine, TaClo, 1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline, Neurotoxin, ANOVA, analysis of variance, α-Synuclein, Chemistry, General Neuroscience, Neurodegeneration, Dopaminergic, DA, dopaminergic, pathology [Nerve Degeneration], SNpc, substantia nigra pars compacta, Substantia Nigra, alpha-Synuclein, metabolism [Neurotoxins], genetics [alpha-Synuclein], MPTP, 1-methy,4-phenyl, 1,2,3,6 tetrahyrdopyridine, Female, Genetically modified mouse, medicine.medical_specialty, DMSO, dimethylsulfoxide, TH, tyrosine hydroxylase, Neurotoxins, Substantia nigra, Mice, Transgenic, Article, 03 medical and health sciences, Parkinsonian Disorders, Internal medicine, medicine, TCE, trichloroethylene, Animals, Humans, metabolism [Trichloroethylene], ddc:610, pathology [Substantia Nigra], PD, Parkinson’s disease, Pars compacta, Dopaminergic Neurons, Wild type, medicine.disease, nervous system diseases, Trichloroethylene, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, nervous system, Nerve Degeneration, Mutation, Parkinson’s disease, drug effects [Substantia Nigra], 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c72fc6dc3fd8505e5e8d6afd86da507Test

المؤلفون: Matteo Santoro, Walter Maetzler, Petros Stathakos, Heather L. Martin, Markus A. Hobert, Tim W. Rattay, Thomas Gasser, John V. Forrester, Daniela Berg, Kevin J. Tracey, Gernot Riedel, Peter Teismann

المصدر: Neurobiology of Disease
Neurobiology of disease 91, 59-68 (2016). doi:10.1016/j.nbd.2016.02.018
Neurobiology of Disease, Vol 91, Iss, Pp 59-68 (2016)

مصطلحات موضوعية: Male, TNF-α, tumour necrosis factor-alpha, Parkinson's disease, metabolism [Tumor Necrosis Factor-alpha], TH, tyrosine-hydroxylase, drug effects [Dopaminergic Neurons], metabolism [Microglia], drug effects [Microglia], PD, Parkinson's disease, pharmacology [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine], HMGB1 Protein, Aged, 80 and over, Cell Death, metabolism [Dopaminergic Neurons], Parkinson Disease, Middle Aged, SNpc, substantia nigra pars compacta, Neuroprotective Agents, Neurology, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, HMGB1 protein, mouse, Female, Microglia, Wt, wild type, HMGB1, high-mobility group box 1, metabolism [Parkinson Disease], MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, chemical and pharmacologic phenomena, pharmacology [Glycyrrhizic Acid], Article, lcsh:RC321-571, RAGE, receptor for advanced glycation endproducts, High-mobility group box 1, receptor for advanced glycation endproducts, ddc:570, HVA, homovanillic acid, Animals, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, MPTP, Aged, CSF, Cerebrospinal fluid, HMGB1 protein, human, pharmacology [Neuroprotective Agents], Tumor Necrosis Factor-alpha, Dopaminergic Neurons, GFAP, glial fibrillary acidic protein, metabolism [HMGB1 Protein], drug effects [Cell Death], Glycyrrhizic Acid, drug therapy [Parkinson Disease], DOPAC, 3,4-Dihydroxyphenylacetic acid, COX, cyclooxygenase, MPP+, 1-methyl-4-phenylpyridinium, Mice, Inbred C57BL, OD, optical density, Disease Models, Animal, H&Y, Hoehn & Yahr

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4bcd188988a849bde590cba7ed6617a6Test
http://europepmc.org/articles/PMC4867789Test

المؤلفون: Thomas W. Rösler, Wolfgang H. Oertel, Candan Depboylu, Günter U. Höglinger, Anderson de Andrade

المصدر: Journal of neurochemistry 133(4), 590-597 (2015). doi:10.1111/jnc.13026

مصطلحات موضوعية: Male, therapeutic use [Neuregulin-1], Time Factors, Receptor, ErbB-4, Dopamine Agents, Nigrostriatal pathway, drug effects [Dopaminergic Neurons], genetics [Receptor, ErbB-4], Striatum, Pharmacology, Biochemistry, Animals, Genetically Modified, Mice, chemistry.chemical_compound, pharmacology [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine], chemically induced [MPTP Poisoning], neuregulin beta, biology, MPTP, Dopaminergic, therapeutic use [Neuroprotective Agents], Substantia Nigra, Neuroprotective Agents, medicine.anatomical_structure, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, medicine.drug, pharmacology [Neuregulin-1], Neuregulin-1, Substantia nigra, Neuroprotection, pathology [MPTP Poisoning], Cellular and Molecular Neuroscience, Dopamine, medicine, Animals, ddc:610, pathology [Substantia Nigra], Dopamine transporter, Dopamine Plasma Membrane Transport Proteins, pharmacology [Neuroprotective Agents], business.industry, Dopaminergic Neurons, deficiency [Receptor, ErbB-4], MPTP Poisoning, Erbb4 protein, mouse, Mice, Inbred C57BL, Disease Models, Animal, pharmacology [Dopamine Agents], nervous system, chemistry, biology.protein, metabolism [Dopamine Plasma Membrane Transport Proteins], business, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5bab3ff3500e4ff65eb72552b0850cTest
https://doi.org/10.1111/jnc.13026Test

المؤلفون: Donato A. Di Monte, Regina Pape, Stefan Schildknecht, Kim Tieu, Marcel Leist

المصدر: Trends in pharmacological sciences 38(6), 541-555 (2017). doi:10.1016/j.tips.2017.03.010

مصطلحات موضوعية: 0301 basic medicine, pathology [Neostriatum], Parkinson's disease, pathology [Dopaminergic Neurons], pharmacokinetics [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine], drug effects [Dopaminergic Neurons], Endogeny, Degeneration (medical), metabolism [Neurodegenerative Diseases], Toxicology, chemistry.chemical_compound, 0302 clinical medicine, drug effects [Neostriatum], pharmacology [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine], metabolism [Neostriatum], Tissue homeostasis, pathology [Astrocytes], chemistry.chemical_classification, chemically induced [MPTP Poisoning], metabolism [Astrocytes], MPTP, metabolism [Dopaminergic Neurons], Neurodegeneration, Dopaminergic, pathology [Neurodegenerative Diseases], Neurodegenerative Diseases, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Psychology, metabolism [MPTP Poisoning], drug effects [Astrocytes], pathology [MPTP Poisoning], 03 medical and health sciences, ddc:570, medicine, Animals, Humans, ddc:610, Pharmacology, Reactive oxygen species, Dopaminergic Neurons, MPTP Poisoning, medicine.disease, nervous system diseases, Neostriatum, 030104 developmental biology, chemistry, nervous system, chemically induced [Neurodegenerative Diseases], Astrocytes, Neuroscience, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddbbc214879ae685ab7dadd3aa4847cbTest
https://pubmed.ncbi.nlm.nih.gov/28442167Test

المؤلفون: Liudmila Mus, Elena Dvoretskova, Ilda Theka, Damiana Leo, Alexander Dityatev, Raul R. Gainetdinov, Vania Broccoli, Gaia Colasante, Maria Teresa Dell’Anno, Stefano Taverna, Giovanni Russo, Serena Giannelli, Fabio Benfenati, Massimiliano Caiazzo, Gianni Pezzoli, Lucian Medrihan

المساهمون: Dell'Anno, Maria Teresa, Caiazzo, Massimiliano, Leo, Damiana, Dvoretskova, Elena, Medrihan, Lucian, Colasante, Gaia, Giannelli, Serena, Theka, Ilda, Russo, Giovanni, Mus, Liudmila, Pezzoli, Gianni, Gainetdinov, Raul R, Benfenati, Fabio, Taverna, Stefano, Dityatev, Alexander, Broccoli, Vania

المصدر: The journal of clinical investigation 124(7), 3215-3229 (2014). doi:10.1172/JCI74664

مصطلحات موضوعية: Male, Dopamine, Cell, drug effects [Dopaminergic Neurons], physiopathology [Brain], pathology [Parkinsonian Disorders], Pharmacology, Designer Drugs, Cell therapy, Mice, pathology [Brain], analogs & derivatives [Clozapine], Premovement neuronal activity, metabolism [Dopamine], Clozapine, Mice, Knockout, Dopaminergic, Brain, Parkinsonian Disorder, genetics [Cell Transdifferentiation], General Medicine, transplantation [Dopaminergic Neurons], medicine.anatomical_structure, physiopathology [Parkinsonian Disorders], Female, Rats, Transgenic, Dopaminergic Neuron, Reprogramming, Human, Research Article, medicine.drug, Cell signaling, Designer Drug, Biology, Parkinsonian Disorders, pharmacology [Clozapine], medicine, Animals, Humans, ddc:610, physiology [Dopaminergic Neurons], therapy [Parkinsonian Disorders], Animal, Dopaminergic Neurons, Electrophysiological Phenomena, Rats, Disease Models, Animal, nervous system, clozapine N-oxide, Cell Transdifferentiation, Rat, Neuron, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddbf0311b5f91393ed619b666d24a3aTest
https://doi.org/10.1172/jci74664Test

المؤلفون: Frank Striggow, Grazyna Debska-Vielhaber, Jürgen Voges, Frank N. Gellerich, Patricia Panther, Andreas Kupsch, Stefan Vielhaber, Hans-Jochen Heinze, Herbert Schwegler, Werner Schmidt, Zemfira Gizatullina

المصدر: Journal of neural transmission 121(10), 1245-1257 (2014). doi:10.1007/s00702-014-1185-3

مصطلحات موضوعية: Male, Parkinson's disease, pathology [Dopaminergic Neurons], drug effects [Dopaminergic Neurons], Mitochondrion, physiology [Cell Death], Oxidative Phosphorylation, Functional Laterality, Rats, Sprague-Dawley, drug effects [Medial Forebrain Bundle], drug effects [Oxidative Phosphorylation], Cell Death, Dopaminergic, drug effects [Mitochondria], Immunohistochemistry, Mitochondria, Psychiatry and Mental health, physiology [Motor Activity], Neurology, physiopathology [Parkinsonian Disorders], medicine.drug, medicine.medical_specialty, Tyrosine 3-Monooxygenase, Substantia nigra, Motor Activity, Biology, Neuroprotection, Parkinsonian Disorders, Dopamine, Internal medicine, medicine, Animals, physiology [Mitochondria], ddc:610, physiology [Dopaminergic Neurons], Oxidopamine, Biological Psychiatry, pathology [Medial Forebrain Bundle], Hydroxydopamine, Dose-Response Relationship, Drug, Pars compacta, Dopaminergic Neurons, drug effects [Motor Activity], physiopathology [Medial Forebrain Bundle], Medial Forebrain Bundle, drug effects [Cell Death], medicine.disease, toxicity [Oxidopamine], metabolism [Tyrosine 3-Monooxygenase], Endocrinology, nervous system, Neurology (clinical), Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4d1b2a6a297acea61985b3f5fc84e4Test
https://doi.org/10.1007/s00702-014-1185-3Test