المؤلفون: Belaïd, Amine, Ndiaye, Papa Diogop, Filippakis, Harilaos, Roux, Jérémie, Röttinger, Eric, Graba, Yacine, Brest, Patrick, Hofman, Paul, Mograbi, Baharia

المساهمون: Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Brigham & Women’s Hospital Boston (BWH), Harvard Medical School Boston (HMS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Infection bactérienne, inflammation, et carcinogenèse digestive, Université Nice Sophia Antipolis (1965 - 2019) (UNS)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UniCA), Laboratoire de Pathologie Clinique et Expérimentale. Hôpital Pasteur Nice, Hôpital Pasteur Nice (CHU), Human Tissue Biobank Unit CHU Nice, Hôpital Pasteur Nice (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011)

المصدر: ISSN: 1568-0096 ; Current Cancer Drug Targets ; https://hal.science/hal-02411388Test ; Current Cancer Drug Targets, 2015, 15 (8), pp.684-702. ⟨10.2174/156800961508151001102452⟩.

مصطلحات موضوعية: Antineoplastic agents/drug effects/autophagy targeted therapy, autophagy addiction/KRAS/BRAF-driven cancers, tumor metabolism, tumor resistance, tumor relapse, tumor metastasis, tumor dormancy, translational medicine, [SDV.CAN]Life Sciences [q-bio]/Cancer

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26452384; hal-02411388; https://hal.science/hal-02411388Test; https://hal.science/hal-02411388/documentTest; https://hal.science/hal-02411388/file/Curr%20Cancer%20Drug%20Targets%202015%20Belaid.pdfTest; PUBMED: 26452384

الإتاحة: https://doi.org/10.2174/156800961508151001102452Test
https://hal.science/hal-02411388Test
https://hal.science/hal-02411388/documentTest
https://hal.science/hal-02411388/file/Curr%20Cancer%20Drug%20Targets%202015%20Belaid.pdfTest

المؤلفون: Günter U. Höglinger, Wolfgang Wurst, Matthias Höllerhage, Natascha Fussi, Christian Behrends, Thomas W. Rösler

المصدر: Neuropharmacology 149, 13-26 (2019). doi:10.1016/j.neuropharm.2019.01.023

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Druggability, drug effects [Dopaminergic Neurons], pharmacology [Pyrimidines], chemistry.chemical_compound, 0302 clinical medicine, metabolism [alpha-Synuclein], pharmacology [Furans], Caspase 7, Diphosphonates, Caspase 3, pharmacology [Diphosphonates], Benzenesulfonates, Dopaminergic, Parkinson Disease, Neuroprotection, Cell biology, MAP1LC3B protein, human, Toxicity, alpha-Synuclein, 4,4,',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonate), Signal transduction, Microtubule-Associated Proteins, drug effects [alpha-Synuclein], Signal Transduction, Cell Survival, drug effects [Cell Survival], PI103, drug effects [Autophagy], metabolism [Parkinson Disease], Cell Line, 03 medical and health sciences, Cellular and Molecular Neuroscience, Autophagy, metabolism [Caspase 3], Humans, ddc:610, metabolism [Caspase 7], Furans, pharmacology [Benzenesulfonates], Pharmacology, Alpha-synuclein, Synucleinopathies, Dopaminergic Neurons, metabolism [Microtubule-Associated Proteins], pharmacology [Pyridines], drug therapy [Parkinson Disease], L 690330, Pyrimidines, 030104 developmental biology, nervous system, chemistry, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625e929d4d566ceb29c99157505daf15Test
https://doi.org/10.1016/j.neuropharm.2019.01.023Test

المؤلفون: Eicke Latz, Victor Saavedra, Matthew Mangan, Anke Penno, Mario A. Lauterbach, Lars Kuerschner, Christoph Thiele

المصدر: Autophagy
Autophagy 17(8), 1947-1961 (2021). doi:10.1080/15548627.2020.1804677

مصطلحات موضوعية: 0301 basic medicine, Autophagosome, Inflammasomes, metabolism [NLR Family, Pyrin Domain-Containing 3 Protein], metabolism [Lysosomes], doxSA, Hereditary sensory and autonomic neuropathy, Macrophage, HSAN1, drug effects [Lysosomes], innate immunity, pharmacology [Sphingolipids], metabolism [Inflammation], metabolism [Autophagosomes], Cell biology, drug effects [Inflammasomes], medicine.anatomical_structure, metabolism [Fibroblasts], Research Paper, drug effects [Autophagy], macrophage, Biology, crystal, drug effects [NLR Family, Pyrin Domain-Containing 3 Protein], 03 medical and health sciences, lipid, ddc:570, Lysosome, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Autophagy, Animals, Molecular Biology, drug effects [Fibroblasts], Inflammation, Sphingolipids, Innate immune system, 030102 biochemistry & molecular biology, Autophagosomes, Cell Biology, Fibroblasts, medicine.disease, Sphingolipid, Mice, Inbred C57BL, 030104 developmental biology, drug effects [Autophagosomes], NLRP3 inflammasome activation, Lysosomes, metabolism [Inflammasomes]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7633b2425588b3dc8eb6ca3aa34a32Test
https://pubmed.ncbi.nlm.nih.gov/32835606Test

المؤلفون: Rodriguez-Muela, Natalia

المصدر: Progress in molecular biology and translational science 172, 157-202 (2020). doi:10.1016/bs.pmbts.2020.03.009

مصطلحات موضوعية: Adult, deficiency [C9orf72 Protein], pathology [Motor Neuron Disease], physiology [Autophagy], drug effects [Autophagy], genetics [Autophagy-Related Proteins], Autophagy-Related Proteins, Mice, Transgenic, genetics [Muscular Atrophy, Spinal], physiology [Autophagy-Related Proteins], Muscular Atrophy, Spinal, Autophagy, Animals, Humans, ddc:530, deficiency [RNA-Binding Protein FUS], Motor Neuron Disease, pathology [Amyotrophic Lateral Sclerosis], genetics [C9orf72 Protein], physiology [C9orf72 Protein], Organelles, DNA Repeat Expansion, physiology [RNA-Binding Protein FUS], C9orf72 Protein, Amyotrophic Lateral Sclerosis, pathology [Neurodegenerative Diseases], genetics [TDP-43 Proteinopathies], Neurodegenerative Diseases, Endocytosis, genetics [Amyotrophic Lateral Sclerosis], pathology [TDP-43 Proteinopathies], Disease Models, Animal, genetics [Neurodegenerative Diseases], TDP-43 Proteinopathies, Mutation, RNA-Binding Protein FUS, genetics [Motor Neuron Disease], genetics [RNA-Binding Protein FUS], pathology [Muscular Atrophy, Spinal]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d62e2b3b2a1db2166925b2c6c1720a6dTest
https://pubmed.ncbi.nlm.nih.gov/32620242Test

المؤلفون: Pierluigi Nicotera, Maria Tiziana Corasaniti, Alessandra Fornarelli, Daniele Bano, Fabio Bertan, Anaïs Marsal-Cots, Annagrazia Adornetto, F Cavaliere, Giacinto Bagetta, Rossella Russo, Luigi Antonio Morrone

المصدر: Scientific reports 9(1), 4881 (2019). doi:10.1038/s41598-019-40887-x
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Clomipramine, lcsh:Medicine, Antidepressive Agents, Tricyclic, Pharmacology, Norepinephrine, Mice, 0302 clinical medicine, lcsh:Science, Neurons, Multidisciplinary, Chemistry, drug effects [Caenorhabditis elegans], 3. Good health, drug effects [Liver], Liver, metabolism [Neurons], medicine.symptom, Signal Transduction, medicine.drug, Affective Disorders, Psychotic, pharmacology [Clomipramine], Serotonin, adverse effects [Antidepressive Agents, Tricyclic], drug effects [Signal Transduction], medicine.drug_class, drug effects [Autophagy], Tricyclic antidepressant, Neurotransmission, Article, 03 medical and health sciences, Cellular neuroscience, Autophagy, medicine, Animals, drug effects [Neurons], Caenorhabditis elegans, pathology [Affective Disorders, Psychotic], adverse effects [Clomipramine], metabolism [Serotonin], metabolism [Norepinephrine], lcsh:R, Disease Models, Animal, 030104 developmental biology, Monoamine neurotransmitter, Mechanism of action, pharmacology [Antidepressive Agents, Tricyclic], drug therapy [Affective Disorders, Psychotic], lcsh:Q, ddc:600, Flux (metabolism), 030217 neurology & neurosurgery, metabolism [Liver]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fded6401b4a4a73809c10548601c4d8aTest
https://doi.org/10.1038/s41598-019-40887-xTest

المؤلفون: Barbara Stiller, Eckhard Mandelkow, Eva Maria Mandelkow, Benjamin Caballero, Ana Maria Cuervo, Yves R. Juste, Inmaculada Tasset, Antonio Diaz, Yipeng Wang

المصدر: Aging cell 17(1), e12692 (2017). doi:10.1111/acel.12692
Aging Cell

مصطلحات موضوعية: 0301 basic medicine, Male, pathology [Tauopathies], Aging, metabolism [Neurodegenerative Diseases], medicine.disease_cause, frontotemporal dementia, 0302 clinical medicine, Phosphorylation, Neurons, Mutation, biology, Neurodegeneration, neurodegeneration, Brain, Neurodegenerative Diseases, Alzheimer's disease, 3. Good health, Tauopathies, Biochemistry, metabolism [Neurons], Original Article, drug effects [Brain], Tauopathy, drug therapy [Neurodegenerative Diseases], autophagy, genetics [Autophagy], Tau protein, drug effects [Autophagy], Context (language use), genetics [Mutation], tau Proteins, 03 medical and health sciences, lysosomes, drug effects [Phosphorylation], mental disorders, medicine, Animals, Humans, drug effects [Neurons], ddc:610, Microautophagy, Rats, Wistar, Autophagy, drug effects [Proteolysis], Original Articles, Cell Biology, medicine.disease, pharmacology [tau Proteins], metabolism [tau Proteins], 030104 developmental biology, Proteostasis, metabolism [Brain], Proteolysis, biology.protein, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b95a92cdc02add0f08c195e65bd176Test

المؤلفون: Adrian Danek, Alessandro Matte, Carlo Zancanaro, Lucia De Franceschi, Elena Tibaldi, Francesca Zonta, Benedikt Bader, Anna Maria Brunati, Seth L. Alper, Mariarita Bertoldi, Alok K. Sharma, Andreas Hermann, Ruth H. Walker, Alexander Storch, Francesca Lupo, Angela Siciliano, Donatella Benati

المصدر: Blood 128(25), 2976-2987 (2016). doi:10.1182/blood-2016-07-727321

مصطلحات موضوعية: Male, Erythrocytes, red cell integrity, metabolism [Autophagy-Related Protein 7], Biochemistry, Macrocyclic, metabolism [Lysosomes], 0302 clinical medicine, Cytosol, Anion Exchange Protein 1, Erythrocyte, metabolism [Erythrocytes], Benzoquinones, Heat-Shock Proteins, Chorea acanthocytosis, Chorea-acanthocytosis, autophagy, Lyn kinase activity, erythropoiesis, metabolism [Autophagy-Related Protein-1 Homolog], drug effects [Cell Differentiation], metabolism [Anion Exchange Protein 1, Erythrocyte], Atg7 protein, human, Multivesicular Bodies, Intracellular Signaling Peptides and Proteins, drug effects [Mitochondria], Cell biology, ultrastructure [Erythroid Cells], Erythropoiesis, metabolism [Intracellular Signaling Peptides and Proteins], Neuroacanthocytosis, Lactams, Immunoprecipitation, Immunology, 03 medical and health sciences, LYN, Humans, metabolism [Multivesicular Bodies], metabolism [Proteasome Endopeptidase Complex], Demography, Anion Exchange Protein 1, lyn protein-tyrosine kinase, medicine.disease, Molecular Weight, 030104 developmental biology, pathology [Erythroid Cells], drug effects [Erythrocytes], metabolism [Heat-Shock Proteins], metabolism [Cytosol], 030217 neurology & neurosurgery, pathology [Neuroacanthocytosis], 0301 basic medicine, pathology [Erythrocytes], drug effects [Cytosol], drug effects [Multivesicular Bodies], Mitochondrion, Autophagy-Related Protein 7, drug effects [Erythroid Cells], Bortezomib, metabolism [src-Family Kinases], hemic and lymphatic diseases, Autophagy-Related Protein-1 Homolog, Phosphorylation, drug effects [Lysosomes], LAMP1, pharmacology [Bortezomib], Cell Differentiation, Hematology, pharmacology [Benzoquinones], Middle Aged, humanities, Mitochondria, Erythrocyte, pharmacology [Lactams, Macrocyclic], src-Family Kinases, drug effects [Erythropoiesis], ultrastructure [Erythrocytes], Female, Adult, congenital, hereditary, and neonatal diseases and abnormalities, ULK1 protein, human, Proteasome Endopeptidase Complex, Lactams, Macrocyclic, drug effects [Autophagy], Biology, Red Cells, Iron, and Erythropoiesis, Erythroid Cells, drug effects [Phosphorylation], mental disorders, medicine, ddc:610, geldanamycin, Autophagy, drug effects [Proteolysis], Cell Biology, metabolism [Mitochondria], Lysosomes, Proteolysis, Membrane protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066e34dc3f3e1d101c1fb0f53a84d33dTest

المؤلفون: Isil Keskin, Elin Forsgren, Jonathan D. Gilthorpe, Anna Birve, Dale J. Lange, Peter M. Andersen, Stefan L. Marklund, Matthis Synofzik, Markus Weber

المصدر: PLOS ONE 11(2), e0150133 (2016). doi:10.1371/journal.pone.0150133
PLoS ONE, Vol 11, Iss 2, p e0150133 (2016)
PLoS ONE

مصطلحات موضوعية: Aging, Biochemistry, 0302 clinical medicine, JUNQ and IPOD, Superoxide Dismutase-1, Animal Cells, Superoxides, genetics [Superoxide Dismutase], Enzyme-Linked Immunoassays, Age of Onset, lcsh:Science, Energy-Producing Organelles, Cells, Cultured, Connective Tissue Cells, DNA Repeat Expansion, Endoplasmic Reticulum Stress, genetics [Amyotrophic Lateral Sclerosis], Aggresome, Dismutases, Neurology, pharmacology [Rotenone], Biological Cultures, Cellular Types, Cellular Structures and Organelles, pathology [Fibroblasts], Genotype, physiology [Autophagy], metabolism [Superoxide Dismutase], SOD1, antagonists & inhibitors [Electron Transport Complex I], Protein Aggregation, Pathological, 03 medical and health sciences, Rotenone, pharmacology [Adenine], Humans, Protease Inhibitors, metabolism [Aging], metabolism [Proteasome Endopeptidase Complex], Immunoassays, C9orf72 Protein, Endoplasmic reticulum, Amyotrophic Lateral Sclerosis, lcsh:R, Biology and Life Sciences, Proteasomes, nutritional and metabolic diseases, Proteins, Fibroblasts, genetics [Proteins], nervous system diseases, 030104 developmental biology, Biological Tissue, Proteasome, nervous system, Case-Control Studies, Mutation, lcsh:Q, 030217 neurology & neurosurgery, 0301 basic medicine, Protein Folding, Cell Lines, animal diseases, lcsh:Medicine, Mitochondrion, Motor Neuron Diseases, Bortezomib, enzymology [Fibroblasts], Medicine and Health Sciences, Multidisciplinary, biology, Cell Death, pharmacology [Bortezomib], SOD1 protein, human, Neurodegenerative Diseases, Enzymes, Mitochondria, Connective Tissue, Cell Processes, Anatomy, analogs & derivatives [Adenine], pharmacology [Protease Inhibitors], Neurovetenskaper, Research Article, Proteasome Endopeptidase Complex, Autophagic Cell Death, drug effects [Autophagy], Enzyme-Linked Immunosorbent Assay, Bioenergetics, Research and Analysis Methods, Superoxide dismutase, Autophagy, ddc:610, pathology [Amyotrophic Lateral Sclerosis], Electron Transport Complex I, Superoxide Dismutase, metabolism [Amyotrophic Lateral Sclerosis], Adenine, Neurosciences, 3-methyladenine, Protein Complexes, Cell Biology, Molecular biology, Solubility, Proteolysis, biology.protein, Enzymology, Immunologic Techniques, Cultured Fibroblasts, C9orf72 protein, human

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04c3ab95ca3fc0c1f8e436bc49b5f91Test
https://pub.dzne.de/record/138409Test

المؤلفون: Campbell, Grant R, Bruckman, Rachel S, Chu, Yen-Lin, Spector, Stephen A

المصدر: Campbell, Grant R; Bruckman, Rachel S; Chu, Yen-Lin; & Spector, Stephen A. (2015). Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1.. The Journal of Biological Chemistry, 290(8), 5028-5040. UC Office of the President: California HIV/AIDS Research Program. Retrieved from: http://www.escholarship.org/uc/item/19z491ccTest
The Journal of biological chemistry, vol 290, iss 8

مصطلحات موضوعية: Male, Biochemistry & Molecular Biology, Macrophage, enzymology, drug effects [Autophagy], HIV Infections, Protein Serine-Threonine Kinases, metabolism [TOR Serine-Threonine Kinases], Medical and Health Sciences, enzymology [Macrophages], Clinical Research, Histone Deacetylase Inhibitor, Autophagy, Autophagy-Related Protein-1 Homolog, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Humans, pathology, virology [Lysosomes], drug therapy [HIV Infections], Macrophages, TOR Serine-Threonine Kinases, Intracellular Signaling Peptides and Proteins, metabolism [Protein-Serine-Threonine Kinases], Life Sciences, Biological Sciences, Protein-Serine-Threonine Kinases, drug effects [Virus Latency], virology, Virus Latency, Histone Deacetylase Inhibitors, Autophagy Autophagy-related Protein 7, Infectious Diseases, 5.1 Pharmaceuticals, physiology [HIV-1], Chemical Sciences, drug therapy, pathology [HIV Infections], HIV-1, virology [Macrophages], HIV/AIDS, Female, Lysosomes, Infection, metabolism [Intracellular Signaling Peptides and Proteins], Human Immunodeficiency Virus, pharmacology [Histone Deacetylase Inhibitors], pathology [Lysosomes]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f525d6453c38e571a4b0534515e17dcaTest
http://www.escholarship.org/uc/item/19z491ccTest

المؤلفون: Carsten Culmsee, Bastian Hengerer, Anderson de Andrade, Matthias Höllerhage, Tobias Hildebrandt, Günter U. Höglinger, Wolfgang H. Oertel, Joachim N. Goebel, Amalia M. Dolga

المصدر: Neurobiology of aging 35(7), 1700-1711 (2014). doi:10.1016/j.neurobiolaging.2014.01.027

مصطلحات موضوعية: Aging, Programmed cell death, pathology [Dopaminergic Neurons], drug effects [Autophagy], pharmacology [Trifluoperazine], pharmacology [Antipsychotic Agents], drug effects [Dopaminergic Neurons], Trifluoperazine, Pharmacology, Biology, toxicity [alpha-Synuclein], Neuroprotection, chemistry.chemical_compound, genetics [Parkinson Disease], Dopaminergic Cell, medicine, Autophagy, Humans, ddc:610, Molecular Targeted Therapy, metabolism [alpha-Synuclein], Cells, Cultured, Alpha-synuclein, cytology [Dopaminergic Neurons], General Neuroscience, Dopaminergic Neurons, Neurodegeneration, Neurotoxicity, Parkinson Disease, medicine.disease, metabolism [Lewy Bodies], drug therapy [Parkinson Disease], Cell biology, pathology [Parkinson Disease], nervous system, chemistry, therapeutic use [Antipsychotic Agents], alpha-Synuclein, Lewy Bodies, Neurology (clinical), Geriatrics and Gerontology, therapeutic use [Trifluoperazine], Developmental Biology, medicine.drug, Antipsychotic Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccc30d9961bcc0365778dcb18dba8c5Test