Decreased Urinary Dopamine Excretion and Disturbed Dopamine/Sodium Relationship in Type 1 Diabetes Mellitus
| العنوان: | Decreased Urinary Dopamine Excretion and Disturbed Dopamine/Sodium Relationship in Type 1 Diabetes Mellitus |
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| المؤلفون: | Erik Gerlo, Alain Dupont, Olga Segers, Guido Somers |
| المساهمون: | Internal Medicine Specializations, Pathologic Biochemistry and Physiology |
| المصدر: | Vrije Universiteit Brussel |
| بيانات النشر: | Wiley, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Time Factors, Fractional excretion of sodium, dopamine excretion, type 1 diabetes mellitus, Dopamine, Endocrinology, Diabetes and Metabolism, Urinary system, Sodium, chemistry.chemical_element, Body Mass Index, Excretion, Endocrinology, Reference Values, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Albuminuria, Humans, Infusions, Intravenous, Glycated Hemoglobin, Analysis of Variance, Type 1 diabetes, business.industry, Dopaminergic, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Case-Control Studies, Creatinine, Female, business, medicine.drug |
| الوصف: | In Type 1 diabetes an increased total body sodium and an impaired ability to excrete a sodium load have been described. A possible involvement of the renal dopaminergic system in this abnormal sodium handling was evaluated through measurements of the urinary output of dopamine, sodium, the dopamine/sodium correlation, and through examining the effect of a dopamine infusion on urinary sodium excretion. Twenty-four hour urinary dopamine excretion was significantly lower in Type 1 diabetic patients as compared to normal controls. A significant correlation between urinary dopamine and sodium excretion was present in normoalbuminuric Type 1 diabetic patients and in normal controls. However, no such correlation could be found in microalbuminuric patients. The increase in fractional excretion of sodium during a 1 h low-dose dopamine (3 micrograms kg-1 min-1) infusion in Type 1 diabetic patients was negatively correlated with diabetes duration. Patients with short duration of diabetes (less than 15 years) had a comparable dopamine-induced increase in fractional excretion of sodium as normal controls. However, patients with longer duration of diabetes (more than 15 years) and microalbuminuric patients displayed no significant changes in sodium output during dopamine infusion. These findings suggest that in Type 1 diabetes mellitus a deficiency of renal dopamine production could be responsible for the impaired sodium handling. Longer duration of the disease and microalbuminuria seem to be associated with an uncoupling of the urinary dopamine/sodium relationship. |
| تدمد: | 1464-5491 0742-3071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af77c7d8c3cdb3d5a9f5972c481e9baTest https://doi.org/10.1111/j.1464-5491.1995.tb00463.xTest |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....1af77c7d8c3cdb3d5a9f5972c481e9ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14645491 07423071 |
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