التفاصيل البيبلوغرافية
| العنوان: |
Peptide-Decorated DNA Nanostructures Promote Site-Specific Hydroxyapatite Growth |
| المؤلفون: |
Alexander L. Danesi (11879109), Dimitra Athanasiadou (11879112), Abdulmateen O. Aderinto (11879115), Prakash Rasie (11879118), Leo Y. T. Chou (7499429), Karina M. M. Carneiro (11879121) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Molecular Biology, Physiology, Developmental Biology, Marine Biology, Virology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, site specifically functionalized, amorphous calcium phosphate, nanoengineered dna structures, mineralized tissue formation, dna origami rectangle, phosphate ions present, describe dna nanostructures, 2 +, specific hydroxyapatite growth, mineral growth occurs, ecm proteins present, phosphate ions, dna nanostructures, mineralized tissues, dna nanotube, dna nanostructure, may occur, incubation time, guiding principle |
| الوصف: |
The guiding principle for mineralized tissue formation is that mineral growth occurs through the interaction of Ca 2+ and phosphate ions with extracellular matrix (ECM) proteins. Recently, nanoengineered DNA structures have been proposed as mimics to ECM scaffolds. However, these principles have not been applied to mineralized tissues. Here, we describe DNA nanostructures, namely, a DNA nanotube and a DNA origami rectangle that are site specifically functionalized with a mineral-promoting “SSEE” peptide derived from ECM proteins present in mineralized tissues. In the presence of Ca 2+ and phosphate ions (mineralizing conditions), site-specific calcium phosphate formation occurred on the DNA nanostructures. Amorphous calcium phosphate or hydroxyapatite was formed depending on the incubation time, shape of the DNA nanostructure, and amount of Ca 2+ and phosphate ions present. The ability to design and control the growth of hydroxyapatite through nanoengineered scaffolds provides insights into the mechanisms that may occur during crystal nucleation and growth of mineralized tissues and can inspire mineralized tissue regeneration strategies. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Peptide-Decorated_DNA_Nanostructures_Promote_Site-Specific_Hydroxyapatite_Growth/17694744Test |
| DOI: |
10.1021/acsami.1c19271.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsami.1c19271.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.5BD2BD6B |
| قاعدة البيانات: |
BASE |
