دورية أكاديمية
THE EFFECT OF FREE AND BOUND NITRIC OXIDE ON BLOOD ENERGY METABOLISM
| العنوان: | THE EFFECT OF FREE AND BOUND NITRIC OXIDE ON BLOOD ENERGY METABOLISM |
|---|---|
| المؤلفون: | А.К. Martusevich, А.G. Solovyova, S.P. Peretyagin |
| بيانات النشر: | ГБОУ ВПО «Нижегородская государственная медицинская академия» Министерства здравоохранения Российской Федерации |
| سنة النشر: | 2013 |
| المجموعة: | CyberLeninka (Scientific Electronic Library) / Научная электронная библиотека «Киберленинка» |
| مصطلحات موضوعية: | nitric oxide, dinitrozyl iron complexes, energy metabolism, lactate dehydrogenase |
| الوصف: | The aim of the investigation was to perform a comparative analysis of free and bound nitric oxide effects on erythrocyte energy metabolic parameters in vitro. Materials and Methods. Two series of experiments were carried out. In the first series we processed blood samples (5 ml) by gaseous nitric oxide (800 μg/l) using three regimens of Plazon apparatus (Russia). In the second series we saturated three aliquot blood samples by 0.05; 0.1 and 0.2 ml of dinitrozyl iron complexes (DNIC) respectively (concentration of the compound was 3 mmol/l). We determined lactate dehydrogenase activity in direct and indirect reactions and lactate level in blood and erythrocytes. A number of derived coefficients were calculated to estimate energy metabolic changes. Results. High concentrations of free nitric oxide were found to inhibit the activity of enzyme systems related to energy metabolism. On the contrary, DNIC have a stimulating effect on erythrocytes energy metabolism. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | unknown |
| الإتاحة: | http://cyberleninka.ru/article/n/the-effect-of-free-and-bound-nitric-oxide-on-blood-energy-metabolismTest http://cyberleninka.ru/article_covers/15708700.pngTest |
| رقم الانضمام: | edsbas.AA565511 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |