التفاصيل البيبلوغرافية
| العنوان: |
Targeting Small GTPases and Their Prenylation in Diabetes Mellitus |
| المؤلفون: |
Edyta Gendaszewska-Darmach (4518808), Malgorzata A. Garstka (5155868), Katarzyna M. Błażewska (1409386) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Physiology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, blood glucose level, mevalonate pathway, diabetes mellitus, diabetes-affected tissues, covalent attachment, T 2D development, Small GTPases, protein prenylation, T 2D, post-translational modifications, glucose homeostasis, inhibition, Hyperglycemia-induced upregulation, pancreatic β- cells, geranylgeranyl group controls, Ras superfamily |
| الوصف: |
A fundamental role of pancreatic β-cells to maintain proper blood glucose level is controlled by the Ras superfamily of small GTPases that undergo post-translational modifications, including prenylation. This covalent attachment with either a farnesyl or a geranylgeranyl group controls their localization, activity, and protein–protein interactions. Small GTPases are critical in maintaining glucose homeostasis acting in the pancreas and metabolically active tissues such as skeletal muscles, liver, or adipocytes. Hyperglycemia-induced upregulation of small GTPases suggests that inhibition of these pathways deserves to be considered as a potential therapeutic approach in treating T2D. This Perspective presents how inhibition of various points in the mevalonate pathway might affect protein prenylation and functioning of diabetes-affected tissues and contribute to chronic inflammation involved in diabetes mellitus (T2D) development. We also demonstrate the currently available molecular tools to decipher the mechanisms linking the mevalonate pathway’s enzymes and GTPases with diabetes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Targeting_Small_GTPases_and_Their_Prenylation_in_Diabetes_Mellitus/14935546Test |
| DOI: |
10.1021/acs.jmedchem.1c00410.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jmedchem.1c00410.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.84EADFA5 |
| قاعدة البيانات: |
BASE |
