دورية أكاديمية
Defining the Design Principles of Skin Epidermis Postnatal Growth.
| العنوان: | Defining the Design Principles of Skin Epidermis Postnatal Growth. |
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| المؤلفون: | Dekoninck, Sophie, Hannezo, Edouard, Sifrim, Alejandro, Miroshnikova, Yekaterina A, Aragona, Mariaceleste, Malfait, Milan, Gargouri, Souhir, de Neunheuser, Charlotte, Dubois, Christine, Voet, Thierry, Wickström, Sara A, Simons, Benjamin D, Blanpain, Cédric |
| بيانات النشر: | Elsevier BV //dx.doi.org/10.1016/j.cell.2020.03.015 Cell |
| سنة النشر: | 2020 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | development, differentiation, epidermis, growth, imbalance, postnatal, progenitors, self-renewal, skin, stem cells, Animals, Outbred Strains, Cell Differentiation, Cell Division, Cell Lineage, Cell Proliferation, Cells, Cultured, Epidermal Cells, Female, Male, Mice, Transgenic |
| الوصف: | During embryonic and postnatal development, organs and tissues grow steadily to achieve their final size at the end of puberty. However, little is known about the cellular dynamics that mediate postnatal growth. By combining in vivo clonal lineage tracing, proliferation kinetics, single-cell transcriptomics, and in vitro micro-pattern experiments, we resolved the cellular dynamics taking place during postnatal skin epidermis expansion. Our data revealed that harmonious growth is engineered by a single population of developmental progenitors presenting a fixed fate imbalance of self-renewing divisions with an ever-decreasing proliferation rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors form a more uniform population compared with adult stem and progenitor cells. Finally, we found that the spatial pattern of cell division orientation is dictated locally by the underlying collagen fiber orientation. Our results uncover a simple design principle of organ growth where progenitors and differentiated cells expand in harmony with their surrounding tissues. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/311040Test |
| DOI: | 10.17863/CAM.58130 |
| الإتاحة: | https://doi.org/10.17863/CAM.58130Test https://www.repository.cam.ac.uk/handle/1810/311040Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.3A8932B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.58130 |
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