المؤلفون: Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

المساهمون: NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Cancer Research UK, CRT Pioneer Fund, Sixth Element Capital

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 8, page 5892-5906 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00155Test

المؤلفون: Huckvale, Rosemary, Harnden, Alice C., Cheung, Kwai-Ming J., Pierrat, Olivier A., Talbot, Rachel, Box, Gary M., Henley, Alan T., de Haven Brandon, Alexis K., Hallsworth, Albert E., Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, Hayes, Angela, Gunnell, Emma A., Brennan, Alfie, Davis, Owen A., Johnson, Louise D., de Klerk, Selby, McAndrew, Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

المساهمون: Cancer Research UK, Sixth Element Capital

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 12, page 8191-8207 ; ISSN 0022-2623 1520-4804

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c02175Test

المؤلفون: Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros

المصدر: British Journal of Cancer ; volume 116, issue 9, page 1166-1176 ; ISSN 0007-0920 1532-1827

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1038/bjc.2017.75Test
http://www.nature.com/articles/bjc201775.pdfTest
http://www.nature.com/articles/bjc201775Test

المؤلفون: Osborne, James D., Matthews, Thomas P., McHardy, Tatiana, Proisy, Nicolas, Cheung, Kwai-Ming J., Lainchbury, Michael, Brown, Nathan, Walton, Michael I., Eve, Paul D., Boxall, Katherine J., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Jamin, Yann, Robinson, Simon P., Westwood, Isaac M., van Montfort, Rob L. M., Leonard, Philip M., Lamers, Marieke B. A. C., Reader, John C., Aherne, G. Wynne, Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian

المساهمون: Engineering and Physical Sciences Research Council, Medical Research Council, Institute of Cancer Research, Royal Cancer Hospital, Cancer Research UK, Department of Health, United Kingdom, Sareum Limited

المصدر: Journal of Medicinal Chemistry ; volume 59, issue 11, page 5221-5237 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.5b01938Test

المؤلفون: Lainchbury, Michael, Matthews, Thomas P., McHardy, Tatiana, Boxall, Kathy J., Walton, Michael I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., de Haven Brandon, Alexis K., Box, Gary, Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian

المصدر: Journal of Medicinal Chemistry ; volume 55, issue 22, page 10229-10240 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/jm3012933Test

المؤلفون: Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.

المصدر: Oncotarget

مصطلحات موضوعية: Lung Neoplasms, Lymphoma, B-Cell, CHK1, Mice, Nude, Apoptosis, Mice, Transgenic, Irinotecan, environment and public health, CCT245737, Deoxycytidine, Proto-Oncogene Proteins c-myc, Proto-Oncogene Proteins p21(ras), Mice, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, CDC2 Protein Kinase, Animals, Humans, antitumor activity, 4-Aminopyridine, Mice, Inbred BALB C, biomarker assay, Drug Synergism, Cell Cycle Checkpoints, Xenograft Model Antitumor Assays, Gemcitabine, Cyclin-Dependent Kinases, enzymes and coenzymes (carbohydrates), Checkpoint Kinase 2, Pyrazines, Checkpoint Kinase 1, Camptothecin, biological phenomena, cell phenomena, and immunity, pharmacology, HT29 Cells, Research Paper, DNA Damage

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::8442ee95d6b0079b6c786a7ec241811fTest
http://europepmc.org/articles/PMC4823038Test

المؤلفون: Yap, Timothy A., Walton, Mike I., Grimshaw, Kayla M., te Poele, Robert H., Eve, Paul D., Valenti, Melanie R., De Haven Brandon, Alexis K., Martins, Vanessa, Zetterlund, Anna, Heaton, Simon P., Heinzmann, Kathrin, Jones, Paul S., Feltell, Ruth E., Reule, Matthias, Woodhead, Steven J., Davies, Thomas G., Lyons, John F., Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Thompson, Neil T., Garrett, Michelle D.

مصطلحات موضوعية: Q Science

العلاقة: Yap, Timothy A., Walton, Mike I., Grimshaw, Kayla M., te Poele, Robert H., Eve, Paul D., Valenti, Melanie R., De Haven Brandon, Alexis K., Martins, Vanessa, Zetterlund, Anna, Heaton, Simon P., and others. Heinzmann, Kathrin, Jones, Paul S., Feltell, Ruth E., Reule, Matthias, Woodhead, Steven J., Davies, Thomas G., Lyons, John F., Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Thompson, Neil T., and Garrett, Michelle D. (hide) (2012) AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity. Clinical Cancer Research, 18 (14). pp. 3912-3923. ISSN 1078-0432. (doi:10.1158/1078-0432.CCR-11-3313 ) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:58561 )

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-11-3313Test
https://kar.kent.ac.uk/58561Test/

المؤلفون: Walton, Mike I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Hallsworth, Albert, Smith, Elizabeth L., Boxall, Kathy J., Lainchbury, Michael, Matthews, Thomas P., Jamin, Yann, Robinson, Simon P., Aherne, G. Wynne, Reader, John C., Chesler, Louis, Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.

مصطلحات موضوعية: Q Science

العلاقة: Walton, Mike I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Hallsworth, Albert, Smith, Elizabeth L., Boxall, Kathy J., Lainchbury, Michael, and others. Matthews, Thomas P., Jamin, Yann, Robinson, Simon P., Aherne, G. Wynne, Reader, John C., Chesler, Louis, Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, and Garrett, Michelle D. (hide) (2012) CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs. Clinical Cancer Research, 18 (20). pp. 5650-5661. ISSN 1078-0432. (doi:10.1158/1078-0432.CCR-12-1322 ) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:58558 )

الإتاحة: https://doi.org/10.1158/1078-0432.CCR-12-1322Test
https://kar.kent.ac.uk/58558Test/

المؤلفون: Gowan, Sharon M., Hardcastle, Anthea, Hallsworth, Albert E., Valenti, Melanie R., Hunter, Lisa-Jane K., de Haven Brandon, Alexis K., Garrett, Michelle D., Raynaud, Florence, Workman, Paul, Aherne, Wynne, Eccles, Suzanne A.

المصدر: ASSAY and Drug Development Technologies ; volume 5, issue 3, page 391-402 ; ISSN 1540-658X 1557-8127

الإتاحة: https://doi.org/10.1089/adt.2006.044Test

المؤلفون: Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

المصدر: Journal of Medicinal Chemistry; 20230101, Issue: Preprints