Real-world costing analysis for diffuse large B-cell lymphoma in British Columbia
| العنوان: | Real-world costing analysis for diffuse large B-cell lymphoma in British Columbia |
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| المؤلفون: | David W. Scott, Stuart Peacock, Dean A. Regier, Sarah Costa, Christian Steidl |
| المصدر: | Current Oncology Volume 26 Issue 2 Pages 4565-113 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Pediatrics, Systemic therapy, 0302 clinical medicine, immune system diseases, Oncology Service, Hospital, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, 030212 general & internal medicine, Child, health care economics and organizations, Aged, 80 and over, Inverse probability weighting, Standard treatment, costs, real-world, censored costing, Fee-for-Service Plans, Health Care Costs, Diffuse large B-cell lymphoma, Middle Aged, Hospitalization, Vincristine, 030220 oncology & carcinogenesis, Child, Preschool, Cohort, Female, Lymphoma, Large B-Cell, Diffuse, Rituximab, inverse probability weighting, Adult, medicine.medical_specialty, Adolescent, Antineoplastic Agents, 03 medical and health sciences, Young Adult, medicine, Humans, Cyclophosphamide, neoplasms, Aged, Costing Series, British Columbia, business.industry, Infant, Newborn, Infant, Retrospective cohort study, medicine.disease, Confidence interval, Standard error, Doxorubicin, Prednisone, business |
| الوصف: | Diffuse large B-cell lymphoma (dlbcl) accounts for 30%&ndash 40% of all non-Hodgkin lymphomas. Approximately 60% of patients are cured with standard treatment. Targeted treatments are being investigated and might improve disease outcomes however, their effect on cancer drug budgets will be significant. For the present study, we conducted an analysis of real-world costs for dlbcl patients treated in British Columbia, useful for health care system planning. Patient records from a retrospective cohort of patients diagnosed with dlbcl in British Columbia during 2004&ndash 2013 were anonymously linked across multiple administrative data sources: systemic therapy, radiotherapy, hospitalizations, oncologist services, outpatient medications, and fee-for-service physician services. Using generalized linear modelling regression, time-dependent costs (in 2015 Canadian dollars) were estimated in 6-month intervals over a 5-year period. The inverse probability weighting method was applied to account for censored observations. Nonparametric bootstrapping was used to estimate standard errors for the mean cost at each time interval. The cohort consisted of 678 patients (5-year overall survival: 67%). Mean age at diagnosis was 64 ± 14 years median follow-up was 3.2 years. Mean total cost of care was highest in the first 6 months after diagnosis ($29,120 95% confidence interval: $28,986 to $29,170) and after disease progression ($18,480 95% confidence interval: $15,187 to $24,772). Systemic therapy and hospitalization costs were the largest cost drivers. At each time interval, costs were observed to be positively skewed. Our results depict real-world costs for the treatment of dlbcl patients with standard chop-r therapy. Cost-model parameters are also provided for economic modelling of dlbcl interventions. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1718-7729 |
| DOI: | 10.3747/co.26.4565 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6580622428575698c62c18498297ac84Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6580622428575698c62c18498297ac84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17187729 |
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| DOI: | 10.3747/co.26.4565 |