التفاصيل البيبلوغرافية
| العنوان: |
Iridium-Catalyzed Intramolecular β‑C–H Alkenylation of Ketones with Alkynes via a Hydride-Transfer Approach |
| المؤلفون: |
Bo Zhou (15092), Shuang Deng (3435830), Yin Xu (159474), Xiaotian Qi (1425286), Guangbin Dong (1288614) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mediated alkyne insertion, avoids strong acids, involving ketone α, trivial task, transfer pathway, redox neutral, economical transformations, coupling partner, corresponding atom, conjugate addition, common alkenes, combined experimental |
| الوصف: |
Direct functionalization of carbonyl β C–H bonds without using directing groups has not been a trivial task, and it is even more challenging to realize the corresponding atom-economical transformations with common alkenes or alkynes as the coupling partner. Here, we describe the development of an iridium-catalyzed intramolecular direct β-alkenylation of ketones with regular alkynes. The reaction is redox neutral, avoids strong acids or bases, and tolerates various functional groups. The combined experimental and computational mechanistic studies reveal a hydride-transfer pathway, involving ketone α,β-desaturation, iridium-hydride-mediated alkyne insertion, conjugate addition, and α-protonation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Iridium-Catalyzed_Intramolecular_C_H_Alkenylation_of_Ketones_with_Alkynes_via_a_Hydride-Transfer_Approach/21713968Test |
| DOI: |
10.1021/jacs.2c11505.s001 |
| الإتاحة: |
https://doi.org/10.1021/jacs.2c11505.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.62F38B6C |
| قاعدة البيانات: |
BASE |
