United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia
| العنوان: | United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia |
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| المؤلفون: | Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., Tack, J., Accarino, A., Barbara, G., Bor, S., Coffin, B., Corsetti, M., De Schepper, H., Dumitrascu, D., Farmer, A., Gourcerol, G., Hauser, G., Hausken, T., Karamanolis, G., Keszthelyi, D., Malagelada, C., Milosavljevic, T., Muris, J., O'Morain, C., Papathanasopoulos, A., Pohl, D., Rumyantseva, D., Sarnelli, G., Savarino, E., Schol, J., Sheptulin, A., Smet, A., Stengel, A., Storonova, O., Storr, M., Tornblom, H., Vanuytsel, T., Velosa, M., Waluga, M., Zarate, N., Zerbib, F., Kestzhelyi, D. |
| المساهمون: | Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R5 - Optimising Patient Care, Family Medicine Education, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris - UFR Médecine Paris Centre [Santé] (UP Médecine Paris Centre), Université de Paris (UP), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service de physiologie digestive, urinaire, respiratoire et de l'exercice [CHU Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), ESNM FD Consensus Grp, Wauters L., Dickman R., Drug V., Mulak A., Serra J., Enck P., Tack J., Accarino A., Barbara G., Bor S., Coffin B., Corsetti M., De Schepper H., Dumitrascu D., Farmer A., Gourcerol G., Hauser G., Hausken T., Karamanolis G., Keszthelyi D., Malagelada C., Milosavljevic T., Muris J., O'Morain C., Papathanasopoulos A., Pohl D., Rumyantseva D., Sarnelli G., Savarino E., Schol J., Sheptulin A., Smet A., Stengel A., Storonova O., Storr M., Tornblom H., Vanuytsel T., Velosa M., Waluga M., Zarate N., Zerbib F., ESNM FD Consensus Group, Wauters, L., Dickman, R., Drug, V., Mulak, A., Serra, J., Enck, P., Tack, J., Accarino, A., Barbara, G., Bor, S., Coffin, B., Corsetti, M., De Schepper, H., Dumitrascu, D., Farmer, A., Gourcerol, G., Hauser, G., Hausken, T., Karamanolis, G., Keszthelyi, D., Malagelada, C., Milosavljevic, T., Muris, J., O'Morain, C., Papathanasopoulos, A., Pohl, D., Rumyantseva, D., Sarnelli, G., Savarino, E., Schol, J., Sheptulin, A., Smet, A., Stengel, A., Storonova, O., Storr, M., Tornblom, H., Vanuytsel, T., Velosa, M., Waluga, M., Zarate, N., Zerbib, F. |
| المصدر: | United European Gastroenterology Journal, 9(3), 307-331. SAGE Publications Inc. United European Gastroenterology Journal r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Volume 9 Issue 3 United European Gastroenterology Journal, SAGE Publications, 2021, 9 (3), pp.307-331. ⟨10.1002/ueg2.12061⟩ Neurogastroenterology and motility United European gastroenterology journal Neurogastroenterology and Motility Neurogastroenterology and Motility, 33(9):e14238. Wiley |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Proton Pump Inhibitor, Delphi Technique, IRRITABLE-BOWEL-SYNDROME, Gastrointestinal Diseases, Physiology, [SDV]Life Sciences [q-bio], Placebo-controlled study, GASTROESOPHAGEAL-REFLUX DISEASE, Sex Factor, PLACEBO-CONTROLLED TRIAL, Epigastric pain, Endoscopy, Gastrointestinal, DOUBLE-BLIND, 0302 clinical medicine, Quality of life, Risk Factors, QUALITY-OF-LIFE, UPPER GASTROINTESTINAL SYMPTOMS, Irritable bowel syndrome, Societies, Medical, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, evidence‐based medicine, based medicine, Gastroenterology, Neurogastroenterology, Postprandial Period, 3. Good health, consensus, endoscopy, evidence‐based medicine, functional dyspepsia, proton pump inhibitors, Europe, Oncology, Neurology, 030220 oncology & carcinogenesis, Anxiety, 030211 gastroenterology & hepatology, Original Article, Female, medicine.symptom, Symptom Assessment, proton pump inhibitors, evidence-based medicine, consensus, endoscopy, functional dyspepsia, Human, medicine.medical_specialty, Consensu, Satiation, evidence‐, Helicobacter Infections, 03 medical and health sciences, Sex Factors, HELICOBACTER-PYLORI, Internal medicine, IMPAIRED GASTRIC ACCOMMODATION, medicine, Humans, DUODENAL ACID EXPOSURE, Dyspepsia, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Gastric emptying, Helicobacter pylori, Endocrine and Autonomic Systems, business.industry, Risk Factor, Evidence-based medicine, NATURAL-HISTORY, NONULCER DYSPEPSIA, medicine.disease, HELICOBACTER-PYLORI INFECTION, Abdominal Pain, Quality of Life, Human medicine, business, Helicobacter Infection |
| الوصف: | Background Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite of its prevalence, FD is associated with major uncertainties in terms of its definition, underlying pathophysiology, diagnosis, treatment, and prognosis. Methods A Delphi consensus was initiated with 41 experts from 22 European countries who conducted a literature summary and voting process on 87 statements. Quality of evidence was evaluated using the grading of recommendations, assessment, development, and evaluation (GRADE) criteria. Consensus (defined as >80% agreement) was reached for 36 statements. Results The panel agreed with the definition in terms of its cardinal symptoms (early satiation, postprandial fullness, epigastric pain, and epigastric burning), its subdivision into epigastric pain syndrome and postprandial distress syndrome, and the presence of accessory symptoms (upper abdominal bloating, nausea, belching), and overlapping conditions. Also, well accepted are the female predominance of FD, its impact on quality of life and health costs, and acute gastrointestinal infections, and anxiety as risk factors. In terms of pathophysiological mechanisms, the consensus supports a role for impaired gastric accommodation, delayed gastric emptying, hypersensitivity to gastric distention, Helicobacter pylori infection, and altered central processing of signals from the gastroduodenal region. There is consensus that endoscopy is mandatory for establishing a firm diagnosis of FD, but that in primary care, patients without alarm symptoms or risk factors can be managed without endoscopy. There is consensus that H. pylori status should be determined in every patient with dyspeptic symptoms and H. pylori positive patients should receive eradication therapy. Also, proton pump inhibitor therapy is considered an effective therapy for FD, but no other treatment approach reached a consensus. The long‐term prognosis and life expectancy are favorable. Conclusions and Inferences A multinational group of European experts summarized the current state of consensus on the definition, diagnosis and management of FD. Key summary Current knowledge Functional dyspepsia is one of the most common conditions encountered in clinical practice.There is a lack of guidance for clinicians in guiding diagnosis and treatment of this prevalent condition.No treatments are currently approved for the treatment of functional dyspepsia in Europe. What is new here A Delphi panel consisting of 41 experts from 22 European countries established the level of consensus on 87 statements regarding functional dyspepsia.The statements reaching consensus serve to guide clinicians in recognizing, diagnosing and treating FD in clinical practice.Endoscopy is mandatory for establishing a firm diagnosis of functional dyspepsia D, but in primary care patients without alarm symptoms or risk factors can be managed without endoscopy. Helicobacter pylori status should be determined in every patient with dyspeptic symptoms and H. Pylori positive patients should receive eradication therapy.Proton pump inhibitor‐therapy is considered an effective therapy for FD, but no other treatment approach reached consensus support. |
| وصف الملف: | application/pdf; Print; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2050-6406 2050-6414 1350-1925 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b15f6cd3308671b03ff931e42db1a0Test https://cris.maastrichtuniversity.nl/en/publications/339d16eb-3577-44eb-b1b4-73d1117ced79Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....56b15f6cd3308671b03ff931e42db1a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20506406 20506414 13501925 |
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