المؤلفون: Elizabeth Daly Hicks, Noah O. Agada, Tyler R. Yates, Matthew S. Kelly, Jonathan S. Tam, Ronald M. Ferdman, Louis R. Dibernardo, John F. Madden, M. Anthony Moody, Mary Louise Markert

المصدر: Frontiers in Immunology, Vol 14 (2023)

مصطلحات موضوعية: athymia, complete DiGeorge syndrome, DiGeorge anomaly, nontuberculous mycobacteria, Mycobacterium kansasii, Mycobacterium avium complex, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1078976/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/e371aef595714601ae24b1d9edcb83d4Test

المؤلفون: Seminario-Vidal, Lucia, Kole, Lauren, Knapp, Charles, Fort, Prem, Kankirawatana, Suthida, Atkinson, T Prescott, McKay, Kristopher M, Theos, Amy

المصدر: Dermatology Online Journal. 22(11)

مصطلحات موضوعية: DiGeorge syndrome, atypical complete DiGeorge syndrome, eczematous eruption, neonatal rash

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/90k681pbTest

المؤلفون: Cathleen Collins (10922654), Julie J. Kim-Chang (10922648), Elena Hsieh (11267900), Abigail Silber (10922650), Matthew O’Hara (10922651), Sarah Kulke (5617931), Megan A. Cooper (8475378)

مصطلحات موضوعية: Medicine, Biotechnology, Immunology, Cancer, Science Policy, Virology, Computational Biology, Biological Sciences not elsewhere classified, Congenital athymia, real-world evidence, cultured thymic tissue, thymic aplasia, cost of care, complete DiGeorge syndrome, 22q11.2 deletion syndrome, healthcare resource utilization, economic burden, I10, I1, I19

العلاقة: https://figshare.com/articles/journal_contribution/Economic_burden_of_congenital_athymia_in_the_United_States_for_patients_receiving_supportive_care_during_the_first_3_years_of_life/15157484Test

الإتاحة: https://doi.org/10.6084/m9.figshare.15157484.v1Test

المصدر: RETHYM US Prescrg formatn, 2021.
Congenital Athymia Patient Registry of RETHYMIC

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05329935Test

المؤلفون: Food and Drug Administration (FDA), National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المصدر: Markert ML, Marques JG, Neven B, Devl BH, McCarthy EA, Chn , Albuquerque AS, Sva SL, Pnata C, de Sat Base G, Vtoro RM, Pard C, Debre M, MahlaouN, Fcher A, Sousa AE. Fst use of thymus transplantatn therapy for FOXN1 defncy (nude/SC): a report of 2 cases. Blood. 2011 Jan 13;117(2):688-96. do 10.1182/blood-2010-06-292490. Epub 2010 Oct 26.
Chn , Devl BH, LYJ, Markert ML. Long-term tolerance to allogene thymus transplants complete Deorge anomaly. Cl munol. 2008 Mar;126(3):277-81. do 10.1016/j.cl.2007.11.009. Epub 2007 Dec 26.
Sel MA, Markert ML, Burchette JL, Herman CM, Turner JW. The cutaneous manestatns of atypal complete Deorge syndrome: a htopatholog and munohtochemal study. J Cutan Pathol. 2008 Apr;35(4):380-5. do 10.1111/j.1600-0560.2007.00816.x.
Markert ML, SarzottM, OzakDA, SempowskGD, Rhe ME, Hale LP, Le Det F, Alexff MJ, LJ, Hauser ER, Haynes BF, Re HE, Skner MA, Mahaffey SM, Jaggers J, Ste LD, Ml MR. Thymus transplantatn complete Deorge syndrome: munolog and safety evaluatns 12 patnts. Blood. 2003 Aug 1;102(3):1121-30. do 10.1182/blood-2002-08-2545. Epub 2003 Apr 17.
Chn , Olson JA, Skner MA, McCarthy EA, Gupton SE, Chen DF, Bonla FA, Roberts RL, Kanaru MG, Devl BH, Markert ML. Mechanms of tolerance to parental parathyro tsue when combed wh human allogene thymus transplantatn. J Allergy Cl munol. 2010 Oct;126(4):814-820.e8. do 10.1016/j.jac2010.07.016. Epub 2010 Sep 15.
Chn , Mner JD, Scheberg P, Douek DC, Markert ML. Thymus transplantatn restores the repertoes of forkhead box prote 3 (FoxP3)+ and FoxP3- T cells complete Deorge anomaly. Cl Exp munol. 2013 Jul;173(1):140-9. do 10.1111/ce12088.
Markert ML, Devlin BH, Chinn IK, McCarthy EA. Thymus transplantation in complete DiGeorge anomaly. Immunol Res. 2009;44(1-3):61-70. doi: 10.1007/s12026-008-8082-5.
Markert ML, Devlin BH, McCarthy EA, Chinn IK, Hale LP. Thymus Transplantation in Thymus Gland Pathology: Clinical, Diagnostic, and Therapeutic Features. Eds Lavinin C, Moran CA, Morandi U, Schoenhuber R. Springer-Verlag Italia, Milan, 2008, pp 255-267.
Markert ML, Devlin BH, Chinn IK, McCarthy EA, Li YJ. Factors affecting success of thymus transplantation for complete DiGeorge anomaly. Am J Transplant. 2008 Aug;8(8):1729-36. doi: 10.1111/j.1600-6143.2008.02301.x. Epub 2008 Jun 28.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297-309. doi: 10.1016/j.smim.2007.10.002. Epub 2007 Nov 26.
Markert ML, Li J, Devlin BH, Hoehner JC, Rice HE, Skinner MA, Li YJ, Hale LP. Use of allograft biopsies to assess thymopoiesis after thymus transplantation. J Immunol. 2008 May 1;180(9):6354-64. doi: 10.4049/jimmunol.180.9.6354.
Markert ML, Devlin BH, Alexieff MJ, Li J, McCarthy EA, Gupton SE, Chinn IK, Hale LP, Kepler TB, He M, Sarzotti M, Skinner MA, Rice HE, Hoehner JC. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood. 2007 May 15;109(10):4539-47. doi: 10.1182/blood-2006-10-048652. Epub 2007 Feb 6.
Markert ML and Devlin BH. Thymic reconstitution (in Rich RR, Shearer WT, Fleischer T, Schroeder HW, Weyand CM, Frew A, eds., Clinical Immunology 3rd edn., Elsevier, Edinburgh) p 1253-1262, 2008.
Markert ML, Devlin BH, McCarthy EA. Thymus transplantation. Clin Immunol. 2010 May;135(2):236-46. doi: 10.1016/j.clim.2010.02.007. Epub 2010 Mar 16.
Markert ML, Alexieff MJ, Li J, Sarzotti M, Ozaki DA, Devlin BH, Sedlak DA, Sempowski GD, Hale LP, Rice HE, Mahaffey SM, Skinner MA. Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. Blood. 2004 Oct 15;104(8):2574-81. doi: 10.1182/blood-2003-08-2984. Epub 2004 Apr 20.
Parathyroid and Thymus Transplantation in DiGeorge Syndrome, #931

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00566488Test

المؤلفون: National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المصدر: Chn , Devl BH, LYJ, Markert ML. Long-term tolerance to allogene thymus transplants complete Deorge anomaly. Cl munol. 2008 Mar;126(3):277-81. do 10.1016/j.cl.2007.11.009. Epub 2007 Dec 26.
Markert ML, SarzottM, OzakDA, SempowskGD, Rhe ME, Hale LP, Le Det F, Alexff MJ, LJ, Hauser ER, Haynes BF, Re HE, Skner MA, Mahaffey SM, Jaggers J, Ste LD, Ml MR. Thymus transplantatn complete Deorge syndrome: munolog and safety evaluatns 12 patnts. Blood. 2003 Aug 1;102(3):1121-30. do 10.1182/blood-2002-08-2545. Epub 2003 Apr 17.
Chn , Mner JD, Scheberg P, Douek DC, Markert ML. Thymus transplantatn restores the repertoes of forkhead box prote 3 (FoxP3)+ and FoxP3- T cells complete Deorge anomaly. Cl Exp munol. 2013 Jul;173(1):140-9. do 10.1111/ce12088.
Chn , Olson JA, Skner MA, McCarthy EA, Gupton SE, Chen DF, Bonla FA, Roberts RL, Kanaru MG, Devl BH, Markert ML. Mechanms of tolerance to parental parathyro tsue when combed wh human allogene thymus transplantatn. J Allergy Cl munol. 2010 Oct;126(4):814-820.e8. do 10.1016/j.jac2010.07.016. Epub 2010 Sep 15.
Markert ML, Devlin BH, Alexieff MJ, Li J, McCarthy EA, Gupton SE, Chinn IK, Hale LP, Kepler TB, He M, Sarzotti M, Skinner MA, Rice HE, Hoehner JC. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood. 2007 May 15;109(10):4539-47. doi: 10.1182/blood-2006-10-048652. Epub 2007 Feb 6.
Markert ML, Devlin BH, McCarthy EA. Thymus transplantation. Clin Immunol. 2010 May;135(2):236-46. doi: 10.1016/j.clim.2010.02.007. Epub 2010 Mar 16.
Markert ML, Devlin BH, Chinn IK, McCarthy EA, Li YJ. Factors affecting success of thymus transplantation for complete DiGeorge anomaly. Am J Transplant. 2008 Aug;8(8):1729-36. doi: 10.1111/j.1600-6143.2008.02301.x. Epub 2008 Jun 28.
Markert ML and Devlin BH. Thymic reconstitution (in Rich RR, Shearer WT, Fleischer T, Schroeder HW, Weyand CM, Frew A, eds., Clinical Immunology 3rd edn., Elsevier, Edinburgh) p 1253-1262, 2008.
Markert ML, Li J, Devlin BH, Hoehner JC, Rice HE, Skinner MA, Li YJ, Hale LP. Use of allograft biopsies to assess thymopoiesis after thymus transplantation. J Immunol. 2008 May 1;180(9):6354-64. doi: 10.4049/jimmunol.180.9.6354.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297-309. doi: 10.1016/j.smim.2007.10.002. Epub 2007 Nov 26.
Markert ML, Devlin BH, McCarthy EA, Chinn IK, Hale LP. Thymus Transplantation in Thymus Gland Pathology: Clinical, Diagnostic, and Therapeutic Features. Eds Lavinin C, Moran CA, Morandi U, Schoenhuber R. Springer-Verlag Italia, Milan, 2008, pp 255-267.
Markert ML, Devlin BH, Chinn IK, McCarthy EA. Thymus transplantation in complete DiGeorge anomaly. Immunol Res. 2009;44(1-3):61-70. doi: 10.1007/s12026-008-8082-5.
Li B, Li J, Devlin BH, Markert ML. Thymic microenvironment reconstitution after postnatal human thymus transplantation. Clin Immunol. 2011 Sep;140(3):244-59. doi: 10.1016/j.clim.2011.04.004. Epub 2011 Apr 16.
Ciupe SM, Devlin BH, Markert ML, Kepler TB. Quantification of total T-cell receptor diversity by flow cytometry and spectratyping. BMC Immunol. 2013 Aug 6;14:35. doi: 10.1186/1471-2172-14-35.
Dose Study of Thymus Transplantation in DiGeorge Anomaly, IND 9836, #932.1

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00576836Test

المؤلفون: National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المصدر: Markert ML, SarzottM, OzakDA, SempowskGD, Rhe ME, Hale LP, Le Det F, Alexff MJ, LJ, Hauser ER, Haynes BF, Re HE, Skner MA, Mahaffey SM, Jaggers J, Ste LD, Ml MR. Thymus transplantatn complete Deorge syndrome: munolog and safety evaluatns 12 patnts. Blood. 2003 Aug 1;102(3):1121-30. do 10.1182/blood-2002-08-2545. Epub 2003 Apr 17.
Chn , Olson JA, Skner MA, McCarthy EA, Gupton SE, Chen DF, Bonla FA, Roberts RL, Kanaru MG, Devl BH, Markert ML. Mechanms of tolerance to parental parathyro tsue when combed wh human allogene thymus transplantatn. J Allergy Cl munol. 2010 Oct;126(4):814-820.e8. do 10.1016/j.jac2010.07.016. Epub 2010 Sep 15.
Markert ML, Alexieff MJ, Li J, Sarzotti M, Ozaki DA, Devlin BH, Sedlak DA, Sempowski GD, Hale LP, Rice HE, Mahaffey SM, Skinner MA. Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome. Blood. 2004 Oct 15;104(8):2574-81. doi: 10.1182/blood-2003-08-2984. Epub 2004 Apr 20.
Markert ML, Devlin BH, McCarthy EA. Thymus transplantation. Clin Immunol. 2010 May;135(2):236-46. doi: 10.1016/j.clim.2010.02.007. Epub 2010 Mar 16.
Markert ML and Devlin BH. Thymic reconstitution (in Rich RR, Shearer WT, Fleischer T, Schroeder HW, Weyand CM, Frew A, eds., Clinical Immunology 3rd edn., Elsevier, Edinburgh) p 1253-1262, 2008.
Markert ML, Devlin BH, Alexieff MJ, Li J, McCarthy EA, Gupton SE, Chinn IK, Hale LP, Kepler TB, He M, Sarzotti M, Skinner MA, Rice HE, Hoehner JC. Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants. Blood. 2007 May 15;109(10):4539-47. doi: 10.1182/blood-2006-10-048652. Epub 2007 Feb 6.
Selim MA, Markert ML, Burchette JL, Herman CM, Turner JW. The cutaneous manifestations of atypical complete DiGeorge syndrome: a histopathologic and immunohistochemical study. J Cutan Pathol. 2008 Apr;35(4):380-5. doi: 10.1111/j.1600-0560.2007.00816.x.
Chinn IK, Devlin BH, Li YJ, Markert ML. Long-term tolerance to allogeneic thymus transplants in complete DiGeorge anomaly. Clin Immunol. 2008 Mar;126(3):277-81. doi: 10.1016/j.clim.2007.11.009. Epub 2007 Dec 26.
Markert ML, Li J, Devlin BH, Hoehner JC, Rice HE, Skinner MA, Li YJ, Hale LP. Use of allograft biopsies to assess thymopoiesis after thymus transplantation. J Immunol. 2008 May 1;180(9):6354-64. doi: 10.4049/jimmunol.180.9.6354.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297-309. doi: 10.1016/j.smim.2007.10.002. Epub 2007 Nov 26.
Markert ML, Devlin BH, Chinn IK, McCarthy EA, Li YJ. Factors affecting success of thymus transplantation for complete DiGeorge anomaly. Am J Transplant. 2008 Aug;8(8):1729-36. doi: 10.1111/j.1600-6143.2008.02301.x. Epub 2008 Jun 28.
Markert ML, Devlin BH, McCarthy EA, Chinn IK, Hale LP. Thymus Transplantation in Thymus Gland Pathology: Clinical, Diagnostic, and Therapeutic Features. Eds Lavinin C, Moran CA, Morandi U, Schoenhuber R. Springer-Verlag Italia, Milan, 2008, pp 255-267.
Markert ML, Devlin BH, Chinn IK, McCarthy EA. Thymus transplantation in complete DiGeorge anomaly. Immunol Res. 2009;44(1-3):61-70. doi: 10.1007/s12026-008-8082-5.
Markert ML, Marques JG, Neven B, Devlin BH, McCarthy EA, Chinn IK, Albuquerque AS, Silva SL, Pignata C, de Saint Basile G, Victorino RM, Picard C, Debre M, Mahlaoui N, Fischer A, Sousa AE. First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases. Blood. 2011 Jan 13;117(2):688-96. doi: 10.1182/blood-2010-06-292490. Epub 2010 Oct 26.
Markert ML, Alexieff MJ, Li J, Sarzotti M, Ozaki DA, Devlin BH, Sempowski GD, Rhein ME, Szabolcs P, Hale LP, Buckley RH, Coyne KE, Rice HE, Mahaffey SM, Skinner MA. Complete DiGeorge syndrome: development of rash, lymphadenopathy, and oligoclonal T cells in 5 cases. J Allergy Clin Immunol. 2004 Apr;113(4):734-41. doi: 10.1016/j.jaci.2004.01.766.
Albuquerque AS, Marques JG, Silva SL, Ligeiro D, Devlin BH, Dutrieux J, Cheynier R, Pignata C, Victorino RM, Markert ML, Sousa AE. Human FOXN1-deficiency is associated with alphabeta double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation. PLoS One. 2012;7(5):e37042. doi: 10.1371/journal.pone.0037042. Epub 2012 May 10.
Chinn IK, Milner JD, Scheinberg P, Douek DC, Markert ML. Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly. Clin Exp Immunol. 2013 Jul;173(1):140-9. doi: 10.1111/cei.12088.
Thymus Transplantation With Immunosuppression, #884

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00579709Test

المؤلفون: National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المصدر: Markert ML, Devl BH, Alexff MJ, LJ, McCarthy EA, Gupton SE, Chn , Hale LP, Kepler TB, He M, SarzottM, Skner MA, Re HE, Hoehner JC. Revw of 54 patnts wh complete Deorge anomaly enrolled protocols for thymus transplantatn: outcome of 44 consecute transplants. Blood. 2007 May 15;109(10):4539-47. do 10.1182/blood-2006-10-048652. Epub 2007 Feb 6.
Markert ML, Alexff MJ, LJ, SarzottM, OzakDA, Devl BH, Sedlak DA, SempowskGD, Hale LP, Re HE, Mahaffey SM, Skner MA. Postnatal thymus transplantatn wh munosuppressn as treatment for Deorge syndrome. Blood. 2004 Oct 15;104(8):2574-81. do 10.1182/blood-2003-08-2984. Epub 2004 Apr 20.
Markert ML and Devl BH. Thym reconstutn ( Rh RR, Shearer WT, Flecher T, Schroeder HW, Weyand CM, Frew A, eds., Clal munology 3rd edn., Elsevr, Edburgh) p 1253-1262, 2008.
Sel MA, Markert ML, Burchette JL, Herman CM, Turner JW. The cutaneous manestatns of atypal complete Deorge syndrome: a htopatholog and munohtochemal study. J Cutan Pathol. 2008 Apr;35(4):380-5. do 10.1111/j.1600-0560.2007.00816.x.
Chn , Devl BH, LYJ, Markert ML. Long-term tolerance to allogene thymus transplants complete Deorge anomaly. Cl munol. 2008 Mar;126(3):277-81. do 10.1016/j.cl.2007.11.009. Epub 2007 Dec 26.
Markert ML, Alexff MJ, LJ, SarzottM, OzakDA, Devl BH, SempowskGD, Rhe ME, Szabolcs P, Hale LP, Buckley RH, Coyne KE, Re HE, Mahaffey SM, Skner MA. Complete Deorge syndrome: development of rash, lymphadenopathy, and oloclonal T cells 5 cases. J Allergy Cl munol. 2004 Apr;113(4):734-41. do 10.1016/j.jac2004.01.766.
Markert ML, SarzottM, OzakDA, SempowskGD, Rhe ME, Hale LP, Le Det F, Alexff MJ, LJ, Hauser ER, Haynes BF, Re HE, Skner MA, Mahaffey SM, Jaggers J, Ste LD, Ml MR. Thymus transplantatn complete Deorge syndrome: munolog and safety evaluatns 12 patnts. Blood. 2003 Aug 1;102(3):1121-30. do 10.1182/blood-2002-08-2545. Epub 2003 Apr 17.
LB, LJ, Devl BH, Markert ML. Thym mroenvonment reconstutn after postnatal human thymus transplantatn. Cl munol. 2011 Sep;140(3):244-59. do 10.1016/j.cl.2011.04.004. Epub 2011 Apr 16.
Chn , Olson JA, Skner MA, McCarthy EA, Gupton SE, Chen DF, Bonla FA, Roberts RL, Kanaru MG, Devl BH, Markert ML. Mechanms of tolerance to parental parathyro tsue when combed wh human allogene thymus transplantatn. J Allergy Cl munol. 2010 Oct;126(4):814-820.e8. do 10.1016/j.jac2010.07.016. Epub 2010 Sep 15.
Markert ML, Devlin BH, McCarthy EA. Thymus transplantation. Clin Immunol. 2010 May;135(2):236-46. doi: 10.1016/j.clim.2010.02.007. Epub 2010 Mar 16.
Markert ML, Li J, Devlin BH, Hoehner JC, Rice HE, Skinner MA, Li YJ, Hale LP. Use of allograft biopsies to assess thymopoiesis after thymus transplantation. J Immunol. 2008 May 1;180(9):6354-64. doi: 10.4049/jimmunol.180.9.6354.
Hudson LL, Louise Markert M, Devlin BH, Haynes BF, Sempowski GD. Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol. 2007 Oct;19(5):297-309. doi: 10.1016/j.smim.2007.10.002. Epub 2007 Nov 26.
Markert ML, Devlin BH, Chinn IK, McCarthy EA, Li YJ. Factors affecting success of thymus transplantation for complete DiGeorge anomaly. Am J Transplant. 2008 Aug;8(8):1729-36. doi: 10.1111/j.1600-6143.2008.02301.x. Epub 2008 Jun 28.
Markert ML, Devlin BH, McCarthy EA, Chinn IK, Hale LP. Thymus Transplantation in Thymus Gland Pathology: Clinical, Diagnostic, and Therapeutic Features. Eds Lavinin C, Moran CA, Morandi U, Schoenhuber R. Springer-Verlag Italia, Milan, 2008, pp 255-267.
Markert ML, Devlin BH, Chinn IK, McCarthy EA. Thymus transplantation in complete DiGeorge anomaly. Immunol Res. 2009;44(1-3):61-70. doi: 10.1007/s12026-008-8082-5.
Chinn IK, Milner JD, Scheinberg P, Douek DC, Markert ML. Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly. Clin Exp Immunol. 2013 Jul;173(1):140-9. doi: 10.1111/cei.12088.
Phase I/II Trial of Thymus Transplantation With Immunosuppression, #950

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT00579527Test

المؤلفون: National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

المصدر: Markert ML, Devl BH, Alexff MJ, LJ, McCarthy EA, Gupton SE, Chn , Hale LP, Kepler TB, He M, SarzottM, Skner MA, Re HE, Hoehner JC. Revw of 54 patnts wh complete Deorge anomaly enrolled protocols for thymus transplantatn: outcome of 44 consecute transplants. Blood. 2007 May 15;109(10):4539-47. do 10.1182/blood-2006-10-048652. Epub 2007 Feb 6.
Markert ML, Devl BH, McCarthy EA. Thymus transplantatn. Cl munol. 2010 May;135(2):236-46. do 10.1016/j.cl.2010.02.007. Epub 2010 Mar 16.
Markert ML, Alexff MJ, LJ, SarzottM, OzakDA, Devl BH, Sedlak DA, SempowskGD, Hale LP, Re HE, Mahaffey SM, Skner MA. Postnatal thymus transplantatn wh munosuppressn as treatment for Deorge syndrome. Blood. 2004 Oct 15;104(8):2574-81. do 10.1182/blood-2003-08-2984. Epub 2004 Apr 20.
Sel MA, Markert ML, Burchette JL, Herman CM, Turner JW. The cutaneous manestatns of atypal complete Deorge syndrome: a htopatholog and munohtochemal study. J Cutan Pathol. 2008 Apr;35(4):380-5. do 10.1111/j.1600-0560.2007.00816.x.
Chn , Devl BH, LYJ, Markert ML. Long-term tolerance to allogene thymus transplants complete Deorge anomaly. Cl munol. 2008 Mar;126(3):277-81. do 10.1016/j.cl.2007.11.009. Epub 2007 Dec 26.
Markert ML, LJ, Devl BH, Hoehner JC, Re HE, Skner MA, LYJ, Hale LP. Use of allograft bpss to assess thymopos after thymus transplantatn. J munol. 2008 May 1;180(9):6354-64. do 10.4049/jmunol.180.9.6354.
Hudson LL, Loue Markert M, Devl BH, Haynes BF, SempowskGD. Human T cell reconstutn Deorge syndrome and H-1 fectn. Sem munol. 2007 Oct;19(5):297-309. do 10.1016/j.sm.2007.10.002. Epub 2007 Nov 26.
Markert ML, Devl BH, Chn , McCarthy EA. Thymus transplantatn complete Deorge anomaly. munol Res. 2009;44(1-3):61-70. do 10.1007/s12026-008-8082-5.
Markert ML, Alexff MJ, LJ, SarzottM, OzakDA, Devl BH, SempowskGD, Rhe ME, Szabolcs P, Hale LP, Buckley RH, Coyne KE, Re HE, Mahaffey SM, Skner MA. Complete Deorge syndrome: development of rash, lymphadenopathy, and oloclonal T cells 5 cases. J Allergy Cl munol. 2004 Apr;113(4):734-41. do 10.1016/j.jac2004.01.766.
Markert ML, Devl BH, McCarthy EA, Chn , Hale LP. Thymus Transplantatn Thymus Gland Pathology: Clal, Dgnost, and Therapeut Features. Eds Lav C, Moran CA, MorandU, Schoenhuber R. Sprger-Verlag al, Man, 2008, pp 255-267.
Markert ML and Devl BH. Thym reconstutn ( Rh RR, Shearer WT, Flecher T, Schroeder HW, Weyand CM, Frew A, eds., Clal munology 3rd edn., Elsevr, Edburgh) p 1253-1262, 2008.
Markert ML, SarzottM, OzakDA, SempowskGD, Rhe ME, Hale LP, Le Det F, Alexff MJ, LJ, Hauser ER, Haynes BF, Re HE, Skner MA, Mahaffey SM, Jaggers J, Ste LD, Ml MR. Thymus transplantatn complete Deorge syndrome: munolog and safety evaluatns 12 patnts. Blood. 2003 Aug 1;102(3):1121-30. do 10.1182/blood-2002-08-2545. Epub 2003 Apr 17.
Cpe SM, Devl BH, Markert ML, Kepler TB. The dynams of T-cell receptor repertoe dersy followg thymus transplantatn for Deorge anomaly. PLoS Comput Bl. 2009 Jun;5(6):e1000396. do 10.1371/journal.pcb1000396. Epub 2009 Jun 12.
Chn , Olson JA, Skner MA, McCarthy EA, Gupton SE, Chen DF, Bonla FA, Roberts RL, Kanaru MG, Devl BH, Markert ML. Mechanms of tolerance to parental parathyro tsue when combed wh human allogene thymus transplantatn. J Allergy Cl munol. 2010 Oct;126(4):814-820.e8. do 10.1016/j.jac2010.07.016. Epub 2010 Sep 15.
Markert ML, Marques JG, Neven B, Devl BH, McCarthy EA, Chn , Albuquerque AS, Sva SL, Pnata C, de Sat Base G, Vtoro RM, Pard C, Debre M, MahlaouN, Fcher A, Sousa AE. Fst use of thymus transplantatn therapy for FOXN1 defncy (nude/SC): a report of 2 cases. Blood. 2011 Jan 13;117(2):688-96. do 10.1182/blood-2010-06-292490. Epub 2010 Oct 26.
LB, LJ, Devl BH, Markert ML. Thym mroenvonment reconstutn after postnatal human thymus transplantatn. Cl munol. 2011 Sep;140(3):244-59. do 10.1016/j.cl.2011.04.004. Epub 2011 Apr 16.
Albuquerque AS, Marques JG, Sva SL, Leo D, Devl BH, Dutrux J, Cheynr R, Pnata C, Vtoro RM, Markert ML, Sousa AE. Human FOXN1-defncy assocted wh alphabeta double-negate and FoxP3+ T-cell expansns that are dtctly modulated upon thym transplantatn. PLoS One. 2012;7(5):e37042. do 10.1371/journal.pone.0037042. Epub 2012 May 10.
Markert ML, Devl BH, Chn , McCarthy EA, LYJ. Factors affectg success of thymus transplantatn for complete Deorge anomaly. Am J Transplant. 2008 Aug;8(8):1729-36. do 10.1111/j.1600-6143.2008.02301.x. Epub 2008 Jun 28.
Heall J, Keller M, Saltzman R, Bun N, McDonald-McGn D, ZakaE, de Vlartay JP, Moshous D, Are B, McCarthy EA, Devl BH, Parh S, Buckley RH, Markert ML. Dgnos of 22q11.2 deletn syndrome and artem defncy two chdren wh T-B-NK+ munodefncy. J Cl munol. 2012 Oct;32(5):1141-4. do 10.1007/s10875-012-9741-9. Epub 2012 Aug 3.
Chn , Mner JD, Scheberg P, Douek DC, Markert ML. Thymus transplantatn restores the repertoes of forkhead box prote 3 (FoxP3)+ and FoxP3- T cells complete Deorge anomaly. Cl Exp munol. 2013 Jul;173(1):140-9. do 10.1111/ce12088.
Cpe SM, Devl BH, Markert ML, Kepler TB. Quantatn of total T-cell receptor dersy by flow cytometry and spectratypg. BMC munol. 2013 Aug 6;14:35. do 10.1186/1471-2172-14-35.
LB, LJ, Hsh CS, Hale LP, LYJ, Devl BH, Markert ML. Characteratn of cultured thymus tsue used for transplantatn wh emphas on promcuous expressn of thyro tsue-spec genes. munol Res. 2009;44(1-3):71-83. do 10.1007/s12026-008-8083-4.
Markert ML. Defects thym development ( Sullan KE, Sthm ER, eds., Sthm's mune Defncs, 2nd edn, Academ Press/Elsevr) p 357 - 379, 2020.
Markert ML, McCarthy EA, Gupton SE, L AP. Cultured thym tsue transplantatn ( Sullan KE, Sthm ER, eds., Sthm's mune Defncs, 2nd edn, Academ Press/Elsevr) p 1229 - 1239, 2020.
Gupton SE, McCarthy EA, Markert ML. Care of Chdren wh Deorge Before and After Cultured Thymus Tsue plantatn. J Cl munol. 2021 Jul;41(5):896-905. do 10.1007/s10875-021-01044-0. Epub 2021 May 18.
Markert ML, Gupton SE, McCarthy EA. Expernce wh cultured thymus tsue 105 chdren. J Allergy Cl munol. 2022 Feb;149(2):747-757. do 10.1016/j.jac2021.06.028. Epub 2021 Aug 4.
Safety and Efficacy of Thymus Transplantation in Complete DiGeorge Anomaly, IND#9836

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT01220531Test

المؤلفون: E Graham, Davies, Melissa, Cheung, Kimberly, Gilmour, Jesmeen, Maimaris, Joe, Curry, Anna, Furmanski, Neil, Sebire, Neil, Halliday, Konstantinos, Mengrelis, Stuart, Adams, Jolanta, Bernatoniene, Ronald, Bremner, Michael, Browning, Blythe, Devlin, Hans Christian, Erichsen, H Bobby, Gaspar, Lizzie, Hutchison, Winnie, Ip, Marianne, Ifversen, T Ronan, Leahy, Elizabeth, McCarthy, Despina, Moshous, Kim, Neuling, Malgorzata, Pac, Alina, Papadopol, Kathryn L, Parsley, Luigi, Poliani, Ida, Ricciardelli, David M, Sansom, Tiia, Voor, Austen, Worth, Tessa, Crompton, M Louise, Markert, Adrian J, Thrasher

المصدر: Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology

مصطلحات موضوعية: Male, 0301 basic medicine, T-Lymphocytes, medicine.medical_treatment, FoxP3, Forkhead box P3, Hematopoietic stem cell transplantation, EpCam, Epithelial cell adhesion molecule, Autoimmune thrombocytopenia, HSCT, Hematopoietic stem cell transplantation, Immune Reconstitution, Postoperative Complications, 0302 clinical medicine, DiGeorge syndrome, Immunology and Allergy, thymus transplantation, Child, CTLA4, Cytotoxic T lymphocyte–associated antigen 4, Cells, Cultured, cTEC, Cortical thymic epithelial cell, AIRE, Autoimmune regulator, athymia, FOXP3, Autoimmune regulator, Europe, ATG, Antithymocyte globulin, Treatment Outcome, Thymus transplantation, Child, Preschool, Female, DGS, DiGeorge syndrome, CHARGE, Coloboma, heart defects, atresia choanae, retardation of growth and development, genital abnormalities, ear abnormalities/deafness, Immunology, Thymus Gland, Biology, Neutropenia, Article, Autoimmune Diseases, 03 medical and health sciences, Organ Culture Techniques, mTEC, Medullary thymic epithelial cell, medicine, Humans, Transplantation, Homologous, LCL, Lymphoblastoid cell line, SCID, Severe combined immunodeficiency, CMV, Cytomegalovirus, TEC, Thymic epithelial cell, TREC, T-cell receptor signal joint excision circle, Infant, cDGS, Complete DiGeorge syndrome, Organ Transplantation, Treg, Regulatory T, medicine.disease, Transplantation, 030104 developmental biology, TCR, T-cell receptor, CK, Cytokeratin, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5497aaf2c51a3e3722a7cc649f13c7e1Test
http://hdl.handle.net/11379/489605Test