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1رسالة جامعية
المؤلفون: Fenollosa Artés, Felip
المساهمون: University/Department: Universitat Politècnica de Catalunya. Departament d'Enginyeria Mecànica
مرشدي الرسالة: Buj Corral, Irene, Gomà Ayats, Joan Ramon
المصدر: TDX (Tesis Doctorals en Xarxa)
مصطلحات موضوعية: This doctoral thesis has been focused on the challenge to obtain, using Additive Manufacturing (AM), models for surgical planning, under the premise that the equipment to obtain them should be accessible to the hospital field. The objective is to spread the use of prototypes as a surgical training tool, upgrading medical practice in the same way that technologies which enhanced radiographs at the time. The reason for using AM, instead of more traditional technologies, is its capacity to materialise, in a straight way, the digital data of the patient anatomy coming from three-dimensional scanning systems, making it possible to achieve personalised models. The results are basically the generation of new knowledge in order to create accessible multi-material 3D printing machines that would allow to obtain models mimicking living tissues. Related to the will to spread this technology, research has focused on open source technologies, mainly Fused Filament Fabrication (FFF), and similar technologies based on catalitzable liquids. This research is aligned with the development work related to AM at CIM UPC, and in this special field there is a close cooperation with Hospital Sant Joan de Déu in Barcelona (HSJD). The first section of the thesis includes a description of the state of the art, including the existing technologies and their application within the medical field. For the first time, basis have been laid for the characterisation of living tissues – primarily soft tissues – to support the selection of materials mimicking them in an AM process, so as to improve the surgical planning experience. The stiffness linked to most of the materials commonly used in 3D printing, makes them unhelpful to simulate tumours and other anatomic references. Then, parameters like density, viscoelasticity, soft materials industry characterisation, soft tissues and vessels elastic modulus, its hardness, mimicking blood and sterilisation requirements, are successively treated. The second section starts exploring FFF 3D printing. Processes are classified from the point of view of multi-materiality, a key factor for surgical planning models, telling multi-nozzle solutions from mixing printheads solutions. A study about probable useful materials (both filaments and liquids) to mimic soft tissues is included. It is stated how liquids, compared to filaments, are more demanding related to additive manufacturing processes, and different ways to print very soft materials are detailed. Finally, six real cases – in which the doctorate has participated in these last years –, involving collaboration with HSJD, are reported. In the origin it can be found the difficulty to perform tumour resection surgeries to children, like neuroblastoma type, and the initiative of Dr. Lucas Krauel. Finally, Section 3 is devoted to the exploration of many concepts (up to 8), activity performed along the last five years thanks to the technical resources of CIM UPC and the academic activity of the UPC students, related to their final degree thesis, therefore reaching the construction of several machines and mechanisms to test them. The wide and systematic research about these concepts makes closer the day to reach a desktop 3D printing multimaterial solution. It is found that the best way to progress is having a plurality of independent printheads in order to enable a 3D printer to integrate some of the researched concepts, thus materialising a possible solution. To sum up, it is raised how a 3D printer for surgical training models should be like, for the purpose of serving as a basis for new developments., Àrees temàtiques de la UPC::Enginyeria mecànica
وصف الملف: application/pdf
الوصول الحر: http://hdl.handle.net/10803/667421Test
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2مؤتمر
مصطلحات موضوعية: Medicine, Cell Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, transforming growth factor, tnf - 593, tgf - 946, seahorse xf96 analyzer, peripheral mononuclear cells, immune cells contributes, bladder pain syndrome, several inflammatory diseases, systemic inflammatory markers, chemokines including interferon, lymphocyte cellular bioenergetics, assess cellular bioenergetics,
+inflammation%22">xlink "> inflammation, several bioenergetic parameters, glycolytic rates compared, bps ) p, plasma cytokine levels, 6 ), interleukin, bps patients compared, cellular bioenergetics الإتاحة: https://doi.org/10.1371/journal.pone.0298981.s001Test
https://figshare.com/articles/presentation/Parametric_correlation_coefficients_of_cytokine_levels_and_mitochondrial_responses_in_monocytes_and_lymphocytes_/25228733Test -
3مؤتمر
المؤلفون: Imrul Kayes Nabil, Zimam Mahmud, Sonia Tamanna, Md Mostafijur Rahman, Gowhar Rashid, Md. Sarowar Hossain, Humaira Binte Asad, Mohammad Amjad Kamal, Md. Zakir Hossain Howlader
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Immunology, Developmental Biology, Cancer, Mental Health, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, potential inverse correlation, carefully selected cohort, bsmi genotypic variants, hypertensive individuals compared, 111 hypertensive individuals, study therefore introduces, statistically significant distinction, control subjects compared, hypertensive patients across, gene polymorphism rs2228570,
+vitamin%22">xlink "> vitamin, significantly higher occurrence, hypertension vulnerability due, foki genotypic variants, vdr gene polymorphisms, hypertensive patients, significantly higher, control study, significant difference -
4مؤتمر
المؤلفون: Imrul Kayes Nabil, Zimam Mahmud, Sonia Tamanna, Md Mostafijur Rahman, Gowhar Rashid, Md. Sarowar Hossain, Humaira Binte Asad, Mohammad Amjad Kamal, Md. Zakir Hossain Howlader
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Immunology, Developmental Biology, Cancer, Mental Health, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, potential inverse correlation, carefully selected cohort, bsmi genotypic variants, hypertensive individuals compared, 111 hypertensive individuals, study therefore introduces, statistically significant distinction, control subjects compared, hypertensive patients across, gene polymorphism rs2228570,
+vitamin%22">xlink "> vitamin, significantly higher occurrence, hypertension vulnerability due, foki genotypic variants, vdr gene polymorphisms, hypertensive patients, significantly higher, control study, significant difference العلاقة: https://figshare.com/articles/presentation/Uncropped_original_gel_images_SF5-SF7_/25409152Test
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5دورية أكاديمية
المصدر: Folia Veterinaria, Vol 67, Iss 4, Pp 61-66 (2023)
مصطلحات موضوعية: monitored cold storage conditions, ndvi-2 compared eid50 potency value, three weeks of freight, Veterinary medicine, SF600-1100
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2453-7837Test
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6دورية أكاديمية
المؤلفون: Anne B. Kruse, Stephan Fortmeier, Kirstin Vach, Elmar Hellwig, Petra Ratka-Krüger, Nadine Schlueter
مصطلحات موضوعية: Medicine, Biotechnology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tested methods led, sra increased significantly, linear regression models, less invasive procedure, compare group differences, dental hard tissue, limited clinical relevance, insignificant roughness increase, ex vivo <, div >< p, corresponding baseline value, investigate surface roughness, affect surface roughness, tissue loss compared, measurable tissue loss, polishing using erythritol, surface roughness, tissue loss, clinical application, roughness values, reducing roughness, enamel compared, 05 <, 001 <
الإتاحة: https://doi.org/10.1371/journal.pone.0286672.s003Test
https://figshare.com/articles/journal_contribution/Loss_values_in_dentin_and_enamel_for_flat_samples_of_each_treatment_group_/25290440Test -
7دورية أكاديمية
المؤلفون: Anne B. Kruse, Stephan Fortmeier, Kirstin Vach, Elmar Hellwig, Petra Ratka-Krüger, Nadine Schlueter
مصطلحات موضوعية: Medicine, Biotechnology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tested methods led, sra increased significantly, linear regression models, less invasive procedure, compare group differences, dental hard tissue, limited clinical relevance, insignificant roughness increase, ex vivo <, div >< p, corresponding baseline value, investigate surface roughness, affect surface roughness, tissue loss compared, measurable tissue loss, polishing using erythritol, surface roughness, tissue loss, clinical application, roughness values, reducing roughness, enamel compared, 05 <, 001 <
الإتاحة: https://doi.org/10.1371/journal.pone.0286672.s001Test
https://figshare.com/articles/journal_contribution/sRa_data_for_all_treatment_groups_on_enamel_and_dentin_/25290434Test -
8دورية أكاديمية
المؤلفون: Anne B. Kruse, Stephan Fortmeier, Kirstin Vach, Elmar Hellwig, Petra Ratka-Krüger, Nadine Schlueter
مصطلحات موضوعية: Medicine, Biotechnology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tested methods led, sra increased significantly, linear regression models, less invasive procedure, compare group differences, dental hard tissue, limited clinical relevance, insignificant roughness increase, ex vivo <, div >< p, corresponding baseline value, investigate surface roughness, affect surface roughness, tissue loss compared, measurable tissue loss, polishing using erythritol, surface roughness, tissue loss, clinical application, roughness values, reducing roughness, enamel compared, 05 <, 001 <
الإتاحة: https://doi.org/10.1371/journal.pone.0286672.s004Test
https://figshare.com/articles/journal_contribution/Significance_values_for_sRa_data_for_all_treatment_groups_on_enamel_upper_triangle_and_dentin_lower_triangle_for_flat_surfaces_/25290443Test -
9دورية أكاديمية
المؤلفون: Vera Lúcia Teixeira de Freitas, Christina Terra Gallafrio Novaes, Ana Marli Christovam Sartori, Noemia Barbosa Carvalho, Sheila Cristina Vicente da Silva, Érika Shimoda Nakanishi, Fernando Salvador, Cleudson Nery de Castro, Rita Cristina Bezerra, Elizabeth Visone Nunes Westphalen, Caroline Medeji Ramos de Oliveira, Felipe Delatorre Busser, Yeh-Li Ho, Renata Buccheri, Carolina Bonilla, Maria Aparecida Shikanai-Yasuda
مصطلحات موضوعية: Medicine, Immunology, Infectious Diseases, Virology, main factors associated, lower cd4 counts, least 58 days, immune response restoration, early antiparasitic treatment, 0 – 5, preemptive antiparasitic treatment, higher viral load, viral load control, applied quantitative pcr, hiv seronegative cases, >/ hiv coinfection, 1 higher chance, negative parasitemia compared, trypanosoma cruzi <, untreated patients showed, quantitative pcr, hiv coinfection, viral loads, higher parasitemia, untreated patients, therapeutic control, reactivated cases, preemptive therapy, period compared, cruzi <
الإتاحة: https://doi.org/10.1371/journal.pntd.0011961.s004Test
https://figshare.com/articles/journal_contribution/Parasitemia_indirect_parasitological_and_molecular_methods_vs_CD4_and_viral_load_VL_in_HIV_treated_T_and_untreated_UT_patients_/25291834Test -
10دورية أكاديمية
المؤلفون: Vera Lúcia Teixeira de Freitas, Christina Terra Gallafrio Novaes, Ana Marli Christovam Sartori, Noemia Barbosa Carvalho, Sheila Cristina Vicente da Silva, Érika Shimoda Nakanishi, Fernando Salvador, Cleudson Nery de Castro, Rita Cristina Bezerra, Elizabeth Visone Nunes Westphalen, Caroline Medeji Ramos de Oliveira, Felipe Delatorre Busser, Yeh-Li Ho, Renata Buccheri, Carolina Bonilla, Maria Aparecida Shikanai-Yasuda
مصطلحات موضوعية: Medicine, Immunology, Infectious Diseases, Virology, main factors associated, lower cd4 counts, least 58 days, immune response restoration, early antiparasitic treatment, 0 – 5, preemptive antiparasitic treatment, higher viral load, viral load control, applied quantitative pcr, hiv seronegative cases, >/ hiv coinfection, 1 higher chance, negative parasitemia compared, trypanosoma cruzi <, untreated patients showed, quantitative pcr, hiv coinfection, viral loads, higher parasitemia, untreated patients, therapeutic control, reactivated cases, preemptive therapy, period compared, cruzi <
الإتاحة: https://doi.org/10.1371/journal.pntd.0011961.s003Test
https://figshare.com/articles/journal_contribution/Parasitemia_vs_HIV_status_in_untreated_HIV_and_HIV_seronegative_patients_/25291831Test