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Retinal thinning and brain atrophy in early MS and CIS

التفاصيل البيبلوغرافية
العنوان: Retinal thinning and brain atrophy in early MS and CIS
بيانات النشر: Linköpings universitet, Avdelningen för neurobiologi Linköpings universitet, Medicinska fakulteten Linköpings universitet, Avdelningen för diagnostik och specialistmedicin Medicinsk strålningsfysik Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV Linköpings universitet, Medicinska fakulteten Linköpings universitet, Avdelningen för samhälle och hälsa Linköpings universitet, Medicinska fakulteten Linköpings universitet, Avdelningen för diagnostik och specialistmedicin Linköpings universitet, Medicinska fakulteten Medicinsk strålningsfysik Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV Linköpings universitet, Avdelningen för neurobiologi Linköpings universitet, Medicinska fakulteten Neurologiska kliniken i Linköping Karolinska Inst, Sweden 2020
تفاصيل مُضافة: Borgström, Max
Tisell, Anders
Link, Hans
Wilhelm, Elisabeth
Lundberg, Peter
Huang-Link, YuMin
نوع الوثيقة: Electronic Resource
مستخلص: Background Optical coherence tomography (OCT) could be complementary to magnetic resonance imaging (MRI) of the brain in monitoring course of multiple sclerosis (MS) and clinically isolated syndrome (CIS). Thinning of neurons in ganglion cell-inner plexiform layer (GCIPL) measured by OCT is assumed to be associated with brain atrophy. Objectives To evaluate association of GCIPL with brain parameters detected by quantitative MRI (qMRI) and MR-spectroscopy (MRS) in early MS and CIS. Methods Seventeen newly diagnosed MS and 18 CIS patients were prospectively included. The patients were assessed at baseline as well as at 1 year follow-up by OCT, qMRI and MRS. Brain parenchymal and myelin volumes (BPV, MYV respectively) and the corresponding fractions (BPF, MYF) were measured with qMRI. Metabolites including myo-inositol (myo-Ins) were measured in the normal-appearing white matter (NAWM) using MRS. T-tests and ANOVA were used to analyze group differences, and linear regression models to evaluate association of GCIPL with BPV, MYV and myo-Ins after correlation analysis. Results Disease activity reflected by lesions on MRI and presence of CSF oligoclonal IgG bands were more prominent in MS compared to CIS. GCIPL, BPV, MYV, BPF and MYF were reduced, while concentration of myo-Ins was increased in MS compared to CIS. Follow-up showed consistency of thinner GCIPL in MS compared to CIS. GCIPL thinning correlated with reduced BPV and MYV (P < .05 for both), but with increased myo-Ins (P < .01). Conclusions Significant GCIPL thinning occurs in early MS and is associated with enhanced brain inflammation and atrophy.
Funding Agencies|Medical Faculty of Linkoping University; County Council of Ostergotland, Sweden [LIO-533241, LIO-607051, LIO-703171, LIO799111]
مصطلحات الفهرس: clinically isolated syndrome (CIS); ganglion cell-inner plexiform layer (GCIPL); Multiple sclerosis (MS); optical coherence tomography (OCT); quantitative magnetic resonance imaging (qMRI); quantitative magnetic resonance-spectroscopy (MRS), Neurology, Neurologi, Article in journal, info:eu-repo/semantics/article, text
DOI: 10.1111.ane.13282
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166911Test
Acta Neurologica Scandinavica, 0001-6314, 2020, 142:5, s. 418-427
الإتاحة: Open access content. Open access content
info:eu-repo/semantics/restrictedAccess
ملاحظة: English
أرقام أخرى: UPE oai:DiVA.org:liu-166911
doi:10.1111/ane.13282
PMID 32416627
ISI:000537587200001
Scopus 2-s2.0-85085875889
1234742900
المصدر المساهم: UPPSALA UNIV LIBR
From OAIster®, provided by the OCLC Cooperative.
رقم الانضمام: edsoai.on1234742900
قاعدة البيانات: OAIster
الوصف
DOI:10.1111.ane.13282