التفاصيل البيبلوغرافية
| العنوان: |
Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress |
| المؤلفون: |
Paul D. O’Dowd, Andres S. Guerrero, Katelyn R. Alley, Hannah C. Pigg, Fiona O’Neill, Justine Meiller, Chloe Hobbs, Daniel A. Rodrigues, Brendan Twamley, Finbarr O’Sullivan, Victoria J. DeRose, Darren M. Griffith |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Molecular Biology, Mental Health, Biological Sciences not elsewhere classified, still poorly understood, seen great success, rna transcription levels, cellular responses observed, complexes successfully mimic, capable phenanthriplatin derivatives, induced nucleolar stress, capable phenanthriplatin complexes, nucleolar stress, nucleolar proteins, pt complexes, phenanthriplatin treatment, well established, vitro <, urgently needed, studies aimed, future design, first examples, existing library, exact mechanisms, different mode, click complexes, biological targets, anticancer drug |
| الوصف: |
It is well established that oxaliplatin, one of the three Pt(II) anticancer drugs approved worldwide, and phenanthriplatin, an important preclinical monofunctional Pt(II) anticancer drug, possess a different mode of action from that of cisplatin and carboplatin, namely, the induction of nucleolar stress. The exact mechanisms that lead to Pt-induced nucleolar stress are, however, still poorly understood. As such, studies aimed at better understanding the biological targets of both oxaliplatin and phenanthriplatin are urgently needed to expand our understanding of Pt-induced nucleolar stress and guide the future design of Pt chemotherapeutics. One approach that has seen great success in the past is the use of Pt-click complexes to study the biological targets of Pt drugs. Herein, we report the synthesis and characterization of the first examples of click-capable phenanthriplatin complexes. Furthermore, through monitoring the relocalization of nucleolar proteins, RNA transcription levels, and DNA damage repair biomarker γH2AX, and by investigating their in vitro cytotoxicity, we show that these complexes successfully mimic the cellular responses observed for phenanthriplatin treatment in the same experiments. The click-capable phenanthriplatin derivatives described here expand the existing library of Pt-click complexes. Significantly they are suitable for studying nucleolar stress mechanisms and further elucidating the biological targets of Pt complexes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Click-Capable_Phenanthriplatin_Derivatives_as_Tools_to_Study_Pt_II_-Induced_Nucleolar_Stress/25407739Test |
| DOI: |
10.1021/acschembio.3c00607.s001 |
| الإتاحة: |
https://doi.org/10.1021/acschembio.3c00607.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.BB53932 |
| قاعدة البيانات: |
BASE |
