المؤلفون: Bernardino Ghetti, Erik Portelius, Kaj Blennow, Adrian L. Oblak, Jasmin Mahler, Nick C. Fox, Lisa M. Häsler, Per Hammarström, Natalie Beschorner, K. Peter R. Nilsson, Stephan A. Kaeser, Tammaryn Lashley, Lary C. Walker, Jay Rasmussen, Diego Sepulveda-Falla, Matthias Staufenbiel, Sofie Nyström, Mathias Jucker, Markus Glatzel, Frank Baumann

المصدر: Proceedings of the National Academy of Sciences of the United States of America 114(49), 13018-13023 (2017). doi:10.1073/pnas.1713215114

مصطلحات موضوعية: Male, 0301 basic medicine, genetics [Plaque, Amyloid], Protein Conformation, Gene Expression, Plaque, Amyloid, genetics [Alzheimer Disease], pathology [Frontal Lobe], Protein aggregation, classification [Plaque, Amyloid], APP protein, human, pathology [Alzheimer Disease], Mice, Amyloid beta-Protein Precursor, 0302 clinical medicine, Protein structure, metabolism [Amyloid beta-Protein Precursor], chemistry [Occipital Lobe], pathology [Occipital Lobe], Genetics, Multidisciplinary, chemistry [Fluorescent Dyes], metabolism [Presenilin-1], Chemistry, Neurodegeneration, genetics [Presenilin-1], Biological Sciences, Phenotype, Temporal Lobe, Frontal Lobe, metabolism [Frontal Lobe], genetics [Amyloid beta-Protein Precursor], chemistry [Peptide Hydrolases], Female, Occipital Lobe, ddc:500, Alzheimer's disease, metabolism [Alzheimer Disease], classification [Alzheimer Disease], Protein Binding, Amyloid, metabolism [Amyloid beta-Peptides], Thiophenes, metabolism [Temporal Lobe], Presenilin, chemistry [Temporal Lobe], Protein Aggregates, PSEN1 protein, human, 03 medical and health sciences, chemistry [Thiophenes], Alzheimer Disease, mental disorders, Presenilin-1, medicine, chemistry [Amyloid], Animals, Humans, pathology [Plaque, Amyloid], Fluorescent Dyes, Amyloid beta-Peptides, classification [Amyloid], metabolism [Occipital Lobe], Posterior cortical atrophy, pathology [Temporal Lobe], medicine.disease, metabolism [Plaque, Amyloid], Disease Models, Animal, Spectrometry, Fluorescence, 030104 developmental biology, Proteolysis, ultrastructure [Amyloid], chemistry [Frontal Lobe], chemistry [Amyloid beta-Peptides], 030217 neurology & neurosurgery, Peptide Hydrolases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3d0e8d1f9bf7f7e58a153b9ac589d6Test
https://doi.org/10.1073/pnas.1713215114Test

المؤلفون: Marius K. Lemberg, Harald Steiner, Christina Scharnagl, Dieter Langosch

المصدر: Trends in biochemical sciences 40(6), 318-327 (2015). doi:10.1016/j.tibs.2015.04.001

مصطلحات موضوعية: Proteases, Proteolysis, metabolism [Peptide Hydrolases], Biology, Cleavage (embryo), Biochemistry, metabolism [Cell Membrane], Presenilin, medicine, Humans, chemistry [Membrane Proteins], Molecular Biology, chemistry.chemical_classification, medicine.diagnostic_test, Protein dynamics, Rhomboid, Cell Membrane, Membrane Proteins, Kinetics, Transmembrane domain, Enzyme, chemistry, chemistry [Amyloid Precursor Protein Secretases], chemistry [Peptide Hydrolases], ddc:540, Amyloid Precursor Protein Secretases, metabolism [Membrane Proteins], Peptide Hydrolases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75762527c38deab910605c51e91db23Test
https://doi.org/10.1016/j.tibs.2015.04.001Test

المؤلفون: Khatib, F., DiMaio, F., Contenders Group, F., Void Crushers Group, F., Cooper, S., Kazmierczyk, M., Gilski, M., Krzywda, S., Zabranska, H., Pichova, I., Thompson, J., Popovi\'c, Z., Jaskolski, M., Baker, D.

المصدر: Nature structural & molecular biology 18, 1175-1177 (2011). doi:10.1038/nsmb.2119

مصطلحات موضوعية: Models, Molecular, Protein Folding, enzymology [Retroviridae], Protein Conformation, chemistry [Viral Proteins], Crystal structure, Computational biology, Biology, Crystallography, X-Ray, Article, Viral Proteins, Biochemistry, Structural Biology, ddc:570, chemistry [Peptide Hydrolases], Retroviral protease, Molecular replacement, Protein folding, Molecular Biology, human activities, Peptide Hydrolases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408b2a58f63b723b05673b2ee590e74bTest
https://europepmc.org/articles/PMC3705907Test/

المؤلفون: Richard M. Page, Harald Steiner, Christian Haass, Edith Winkler, Amelie Gutsmiedl, Akio Fukumori

المصدر: The journal of biological chemistry 285(23), 17798-17810 (2010). doi:10.1074/jbc.M110.103283

مصطلحات موضوعية: genetics [Phenylalanine], Phenylalanine, Mutant, Amino Acid Motifs, physiology [Amyloid beta-Protein Precursor], chemistry [Peptides], Peptide, Plasma protein binding, Cleavage (embryo), Biochemistry, Models, Biological, Cell Line, pharmacology [Anti-Inflammatory Agents, Non-Steroidal], Amyloid beta-Protein Precursor, Alzheimer Disease, medicine, Humans, Molecular Biology, Gamma secretase, chemistry.chemical_classification, Immunoassay, biology, Cell-Free System, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, medicine.disease, metabolism [Amyloid Precursor Protein Secretases], Transmembrane domain, chemistry, Protein Synthesis and Degradation, genetics [Amyloid beta-Protein Precursor], chemistry [Peptide Hydrolases], ddc:540, Mutation, biology.protein, Alzheimer's disease, Amyloid Precursor Protein Secretases, Peptides, Amyloid precursor protein secretase, metabolism [Alzheimer Disease], Protein Binding, Peptide Hydrolases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16d16ae5dbab15510628cded650e667Test