دورية أكاديمية
Current and future therapeutic approaches of CFTR and airway dysbiosis in an era of personalized medicine
| العنوان: | Current and future therapeutic approaches of CFTR and airway dysbiosis in an era of personalized medicine |
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| المؤلفون: | Kirti Upadhyay, Nitu Nigam, Surbhi Gupta, Surya Kant Tripathi, Amita Jain, Bipin Puri |
| المصدر: | Journal of Family Medicine and Primary Care, Vol 13, Iss 6, Pp 2200-2208 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | airway dysbiosis, cftr therapeutic approaches, personalized medicine, Medicine |
| الوصف: | Cystic fibrosis (CF) is a life-threatening genetic disorder caused by mutations in the CFTR gene. This leads to a defective protein that impairs chloride transport, resulting in thick mucus buildup and chronic inflammation in the airways. The review discusses current and future therapeutic approaches for CFTR dysfunction and airway dysbiosis in the era of personalized medicine. Personalized medicine has revolutionized CF treatment with the advent of CFTR modulator therapies that target specific genetic mutations. These therapies have significantly improved patient outcomes, slowing disease progression, and enhancing quality of life. It also highlights the growing recognition of the airway microbiome’s role in CF pathogenesis and discusses strategies to modulate the microbiome to further improve patient outcomes. This review discusses various therapeutic approaches for cystic fibrosis (CFTR) mutations, including adenovirus gene treatments, nonviral vectors, CRISPR/cas9 methods, RNA replacement, antisense-oligonucleotide-mediated DNA-based therapies, and cell-based therapies. It also introduces airway dysbiosis with CF and how microbes influence the lungs. The review highlights the importance of understanding the cellular and molecular causes of CF and the development of personalized medicine to improve quality of life and health outcomes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-4863 2278-7135 |
| العلاقة: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1085_23Test; https://doaj.org/toc/2249-4863Test; https://doaj.org/toc/2278-7135Test |
| DOI: | 10.4103/jfmpc.jfmpc_1085_23 |
| الوصول الحر: | https://doaj.org/article/de1575d0645f4a13b2ecf813d1c35fb9Test |
| رقم الانضمام: | edsdoj.1575d0645f4a13b2ecf813d1c35fb9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22494863 22787135 |
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| DOI: | 10.4103/jfmpc.jfmpc_1085_23 |