المؤلفون: Lachhi, Reddy, V., Avula, V. K. R., Zyryanov, G. V., Vallela, S., Anireddy, J. S., Pasupuleti, V. R., Chamarthi, N. R., Зырянов, Г. В.

المصدر: Bioorg. Chem. ; Bioorganic Chemistry

مصطلحات موضوعية: 2,3-DIHYDRO-1H-INDEN-1-AMINE, 2HCK ENZYME GROWTH INHIBITION, ADMET PROPERTIES, ANTIOXIDANT ACTIVITY, MOLECULAR DOCKING STUDIES, UREA/THIO-UREA DERIVATIVE, 1 (2,3 DIHYDRO 1H INDEN 1 YL) 3 (4 FLUOROPHENYL)UREA, 1,1 DIPHENYL 2 PICRYLHYDRAZYL, ANTIOXIDANT, ASCORBIC ACID, CELL NUCLEUS RECEPTOR, FREE RADICAL, PHOSPHOTRANSFERASE INHIBITOR, PROTEIN TYROSINE KINASE INHIBITOR, PROTEINASE INHIBITOR, THIOUREA DERIVATIVE, UNCLASSIFIED DRUG, UREA DERIVATIVE, LIGAND, NEUROPROTECTIVE AGENT, PROTEIN KINASE INHIBITOR, PROTEIN TYROSINE KINASE, THIOUREA, UREA, ANIMAL CELL, ARTICLE, BLOOD BRAIN BARRIER, CACO-2 CELL LINE, CARBON NUCLEAR MAGNETIC RESONANCE, CATALYST

وصف الملف: application/pdf

العلاقة: Hunig's base catalyzed synthesis of new 1-(2,3-dihydro-1H-inden-1-yl)-3-aryl urea/thiourea derivatives as potent antioxidants and 2HCK enzyme growth inhibitors / V. Lachhi Reddy, V. K. R. Avula, G. V. Zyryanov, et al. — DOI 10.1016/j.bioorg.2019.103558 // Bioorganic Chemistry. — 2020. — Vol. 95. — 103558.; 452068; Final; All Open Access, Green; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077326480&doi=10.1016%2fj.bioorg.2019.103558&partnerID=40&md5=02d7e1fb69b451ec09a0895de668ee96Test; http://eprints.ums.edu.my/25099/1/Hunig%27s%20base%20catalyzed%20synthesis%20of%20new%201%20%282,3-dihydro%201H%20inden%201%20yl%29%203%20aryl%20urea%20%20thiourea%20derivatives%20as%20potent%20antioxidants%20and%202HCK%20enzyme%20growth%20inhibitors.pdfTest; http://elar.urfu.ru/handle/10995/101611Test; 85077326480

الإتاحة: https://doi.org/10.1016/j.bioorg.2019.103558Test
http://elar.urfu.ru/handle/10995/101611Test
http://eprints.ums.edu.my/25099/1/Hunig%27s%20base%20catalyzed%20synthesis%20of%20new%201%20%282,3-dihydro%201H%20inden%201%20yl%29%203%20aryl%20urea%20%20thiourea%20derivatives%20as%20potent%20antioxidants%20and%202HCK%20enzyme%20growth%20inhibitors.pdfTest

المؤلفون: Broekema, Marjoleine F., Massink, Maarten P.G., Donato, Cinzia, de Ligt, Joep, Schaarschmidt, Joerg, Borgman, Anouska, Schooneman, Marieke G., Melchers, Diana, Gerding, Martin N., Houtman, René, Bonvin, Alexandre M.J.J., Majithia, Amit R., Monajemi, Houshang, van Haaften, Gijs W., Soeters, Maarten R., Kalkhoven, Eric

المساهمون: NMR Spectroscopy, Sub NMR Spectroscopy

مصطلحات موضوعية: Adipose tissue, FPLD3, Lipodystrophy, Nuclear receptor, PPARG, article, colon carcinoma cell line, colorectal cancer, controlled study, dimerization, DNA binding, genetic association, genetic susceptibility, human, human cell, in vitro study, ligand binding, missense mutation, phenotype, protein function, structure activity relation, amino acid, cell nucleus receptor, endogenous compound, peroxisome proliferator activated receptor gamma, retinoid X receptor alpha

وصف الملف: image/pdf

العلاقة: https://dspace.library.uu.nl/handle/1874/375456Test

الإتاحة: https://dspace.library.uu.nl/handle/1874/375456Test

المؤلفون: Yuan, C, Chakraborty, S, Chitta, K.K, Subramanian, S, Lim, T.E, Han, W, Bhanu Prakash, K.N, Sugii, S

المساهمون: MECHANOBIOLOGY INSTITUTE, DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20201031

مصطلحات موضوعية: cell nucleus receptor, 3T3-L1 cell line, accuracy, adipocyte, adipogenesis, adipose derived mesenchymal stem cell, adipose tissue cell, algorithm, animal cell, Article, cell density, cell differentiation, controlled study, embryoid body, fast adipogenesis tracking system, human, human cell, induced pluripotent stem cell, ligand binding, mesenchymal stem cell, mouse, nonhuman, priority journal, quantitative analysis

العلاقة: Yuan, C, Chakraborty, S, Chitta, K.K, Subramanian, S, Lim, T.E, Han, W, Bhanu Prakash, K.N, Sugii, S (2019). Fast Adipogenesis Tracking System (FATS) - A robust, high-throughput, automation-ready adipogenesis quantification technique 10 Technology 1004 Medical Biotechnology. Stem Cell Research and Therapy 10 (1) : 38. ScholarBank@NUS Repository. https://doi.org/10.1186/s13287-019-1141-0Test; https://scholarbank.nus.edu.sg/handle/10635/178049Test

الإتاحة: https://doi.org/10.1186/s13287-019-1141-0Test
https://scholarbank.nus.edu.sg/handle/10635/178049Test

المؤلفون: Çakı, O., …, Karaçalı, B.

مصطلحات موضوعية: Compound Similarity, Chemoinformatics, Compound-Protein Interactions, Drug Discovery, Machine Learning, Cost functions, Drug interactions, Learning algorithms, Learning systems, Supervised learning, Compound-protein interaction, In-silico, Interaction prediction, Machine-learning, Protein interaction, Quasi-supervised learning, True positive, Proteins, alpha 2C adrenergic receptor, amcinonide, beta 1 adrenergic receptor, beta 2 adrenergic receptor, betaxolol, bisoprolol, cell nucleus receptor, chenodeoxycholic acid, chlorpromazine, chlorpromazine derivative, chlorpromazine hibenzate, chlorpromazine phenolphthalinate

العلاقة: Molecular Informatics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11147/14200Test; https://doi.org/10.1002/minf.202100118Test; 41; 2-s2.0-85119954344

الإتاحة: https://doi.org/10.1002/minf.202100118Test
https://hdl.handle.net/11147/14200Test

المؤلفون: Liu Y., Wu M., Miao C., Zhao P., Li X.-L.

المساهمون: DEPT OF COMPUTER SCIENCE

المصدر: Unpaywall 20191101

مصطلحات موضوعية: cell nucleus receptor, enzyme, G protein coupled receptor, ion channel, drug, ligand, protein, accuracy, algorithm, area under the curve, area under the precision recall curve, Article, controlled study, drug target interaction, drug targeting, information processing, neighborhood regularized logistic matrix factorization, observation, prediction, probability, receiver operating characteristic, statistical concepts, biology, chemistry, drug development, metabolism, procedures, Algorithms, Computational Biology, Drug Discovery

العلاقة: Liu Y., Wu M., Miao C., Zhao P., Li X.-L. (2016). Neighborhood Regularized Logistic Matrix Factorization for Drug-Target Interaction Prediction. PLoS Computational Biology 12 (2) : e1004760. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pcbi.1004760Test; https://scholarbank.nus.edu.sg/handle/10635/161924Test

الإتاحة: https://doi.org/10.1371/journal.pcbi.1004760Test
https://scholarbank.nus.edu.sg/handle/10635/161924Test

المؤلفون: Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S

المساهمون: DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20201031

مصطلحات موضوعية: C reactive protein, cell nucleus receptor, chemokine, collagen antibody, cytokine, gamma interferon, interleukin 10, interleukin 17, macrophage inflammatory protein 1alpha, pregnane derivative, pregnane X receptor, RANTES, solomonsterol A, tumor necrosis factor alpha, unclassified drug, adaptive immunity, animal experiment, animal model, antiinflammatory activity, article, controlled study, histopathology, immunopathology, inflammation, innate immunity, lymph node, male, mouse, nonhuman, rheumatoid arthritis

العلاقة: Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S (2014). Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis. Marine Drugs 12 (1) : 36-53. ScholarBank@NUS Repository. https://doi.org/10.3390/md12010036Test; https://scholarbank.nus.edu.sg/handle/10635/181535Test

الإتاحة: https://doi.org/10.3390/md12010036Test
https://scholarbank.nus.edu.sg/handle/10635/181535Test

المؤلفون: Kırmızıbayrak, Petek Ballar, Gözen, Oğuz, Erzurumlu, Yalçın, Barrio, R, Sutherland, JD, Rodriguez, MS

المساهمون: Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Moleküler Biyoloji ve Genetik Bölümü., Tepedelen, Burcu Erbaykent, CNH-6913-2022

مصطلحات موضوعية: Male, Unclassified drug, Biochemistry & molecular biology, Carcinogenesis, Protein function, Carboxy terminal sequence, Androgen, Unfolded protein response, Amino terminal sequence, Wild-type spop, Regulator protein, Pathology, Cyclin D1, Cancer inhibition, Proteasome endopeptidase complex, Oncogene myc, Priority journal, Prostate cancer, Cell-proliferation, Transcriptional activity, Cyclin dependent kinase inhibitor 1B, Cullin RING ubiquitin ligase, Endoplasmic reticulum associated degradation, Androgen receptor, Ubiquitin ligase SIAH2, Protein p27, Prostate tumor, Deubiquitination, Prostatic neoplasms, Deubiquitinating enzymes, Protein homeostasis, Prostate specific antigen, Protein NKX 3 1, Protein p21, Human, Research & experimental medicine, DNA repair, Ubiquitin protein ligase NEDD4, Amino acid sequence, Protein kinase B, Ubiquitin-like, Homeobox gene, Autophagy, Tumor-suppressor gene, Humans, Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, Medicine, research & experimental, Deubiquitinase, Ubiquitin-Specific Proteases, Ubiquitin, RING finger E3 ubiquitin ligase, Androgen receptor-activty, Proteasome, Deubiquitinating enzyme USP12, Ubiquitination, Sumoylation, Nonhuman, Ligase, Metabolism, Myc protein, Proteostasis, Enzymology, Protein expression, Heat-shock proteins, Cell nucleus receptor, Autophagy (cellular), Endoplasmic reticulum-associated degradation, Epithelial mesenchymal transition, Ubiquitin protein ligase E3, Phosphatidylinositol 3 kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______9458::9417a90ad155f532ada7c63e64bf5b99Test
http://hdl.handle.net/11452/30992Test

المؤلفون: Renga B., Francisci D., D'Amore C., Schiaroli E., Mencarelli A., Cipriani S., Baldelli F., Fiorucci S.

المساهمون: DUKE-NUS MEDICAL SCHOOL, NUSHS PROJECT

المصدر: Unpaywall 20191101

مصطلحات موضوعية: CD36 antigen, CD40 antigen, CD86 antigen, cell nucleus receptor, farnesoid X receptor, intercellular adhesion molecule 1, Janus kinase 1, monocyte chemotactic protein 1, peptide vaccine, peroxisome proliferator activated receptor gamma, protein p17, receptor for activated C kinase 1, recombinant protein, STAT1 protein, 2,4 thiazolidinedione derivative, 3 [2 [2 chloro 4 [3 (2,6 dichlorophenyl) 5 isopropyl 4 isoxazolylmethoxy]phenyl]vinyl]benzoic acid, CD14 antigen, cell receptor, cell surface receptor, drug derivative, farnesoid X-activated receptor, fludarabine, Gag protein, GNB2L1 protein, human, guanine nucleotide binding protein, Human immunodeficiency virus antigen, isoxazole derivative, Janus kinase, p17 protein

العلاقة: Renga B., Francisci D., D'Amore C., Schiaroli E., Mencarelli A., Cipriani S., Baldelli F., Fiorucci S. (2012). The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. PLoS ONE 7 (4) : e35924. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0035924Test; https://scholarbank.nus.edu.sg/handle/10635/161986Test

الإتاحة: https://doi.org/10.1371/journal.pone.0035924Test
https://scholarbank.nus.edu.sg/handle/10635/161986Test

المؤلفون: Swetha Vallela, Visweswara Rao Pasupuleti, Grigoriy V. Zyryanov, Venkataramana Lachhi Reddy, Naga Raju Chamarthi, Jaya Shree Anireddy, Vijay Kumar Reddy Avula

المصدر: Bioorg. Chem.
Bioorganic Chemistry

مصطلحات موضوعية: PHYSICAL CHEMISTRY, Antioxidant, medicine.medical_treatment, IC50, 01 natural sciences, Biochemistry, Antioxidants, PROTEIN TYROSINE KINASE, CELL NUCLEUS RECEPTOR, CHEMISTRY, ANTIOXIDANT, DRUG ABSORPTION, ELEMENTAL ANALYSIS, Drug Discovery, HUMAN CELL, Urea, chemistry.chemical_classification, HUMAN, THIOUREA DERIVATIVE, DRUG DISTRIBUTION, QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP, LIGANDS, PROTEIN KINASE INHIBITORS, IN VITRO STUDY, PROTEIN-TYROSINE KINASES, Stereochemistry, Radical, UREA/THIO-UREA DERIVATIVE, CARBON NUCLEAR MAGNETIC RESONANCE, Residue (chemistry), QUANTITATIVE STRUCTURE ACTIVITY RELATION, MDCK CELL LINE, 2,3-DIHYDRO-1H-INDEN-1-AMINE, NONHUMAN, Humans, FREE RADICAL, CACO-2 CELL LINE, DRUG METABOLISM, Molecular Biology, 010405 organic chemistry, CATALYSIS, 0104 chemical sciences, 1,1 DIPHENYL 2 PICRYLHYDRAZYL, PROTON NUCLEAR MAGNETIC RESONANCE, chemistry, CACO-2 CELLS, THIOUREA, MOLECULAR DOCKING STUDIES, NEUROPROTECTIVE AGENT, BLOOD-BRAIN BARRIER, DRUG EXCRETION, ELECTROSPRAY MASS SPECTROMETRY, MOLECULAR DOCKING SIMULATION, Quantitative Structure-Activity Relationship, UNCLASSIFIED DRUG, Ligands, chemistry.chemical_compound, PROTEIN KINASE INHIBITOR, ANTIOXIDANTS, MOLECULAR DOCKING, 1 (2,3 DIHYDRO 1H INDEN 1 YL) 3 (4 FLUOROPHENYL)UREA, PRIORITY JOURNAL, 2HCK ENZYME GROWTH INHIBITION, CATALYST, Hydrogen bond, Thiourea, HUMANS, Protein-Tyrosine Kinases, Molecular Docking Simulation, NEUROPROTECTIVE AGENTS, Neuroprotective Agents, BLOOD BRAIN BARRIER, Blood-Brain Barrier, ASCORBIC ACID, NUCLEOPHILICITY, PHOSPHOTRANSFERASE INHIBITOR, ADMET PROPERTIES, PLASMA PROTEIN BINDING, Catalysis, medicine, ARTICLE, Protein Kinase Inhibitors, Aryl, DRUG SYNTHESIS, Organic Chemistry, PROTEIN TYROSINE KINASE INHIBITOR, UREA DERIVATIVE, ULTRAVIOLET RADIATION, CONTROLLED STUDY, 010404 medicinal & biomolecular chemistry, Enzyme, ANIMAL CELL, CELL PROLIFERATION, THIN LAYER CHROMATOGRAPHY, LIGAND, UREA, Caco-2 Cells, PROTEINASE INHIBITOR, ANTIOXIDANT ACTIVITY

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc0762df3d5d57522edfdd207388aa1Test
https://pubmed.ncbi.nlm.nih.gov/31911311Test

المؤلفون: Mencarelli A., Distrutti E., Renga B., D'Amore C., Cipriani S., Palladino G., Donini A., Ricci P., Fiorucci S.

المساهمون: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL), DUKE-NUS MEDICAL SCHOOL

المصدر: Unpaywall 20191101

مصطلحات موضوعية: adiponectin, cell nucleus receptor, ciprofloxacin, farnesoid X receptor, gamma interferon, interleukin 6, leptin, liver X receptor, metronidazole, peroxisome proliferator activated receptor alpha, peroxisome proliferator activated receptor gamma, pregnane X receptor, probiotic agent, tumor necrosis factor alpha, tumor necrosis factor alpha inhibitor, VSL3, cell receptor, cytokine, farnesoid X-activated receptor, messenger RNA, orphan nuclear receptor, steroid receptor, trinitrobenzenesulfonic acid, abdominal abscess, abdominal fat, adipose tissue, adult, animal experiment, animal model, animal tissue

العلاقة: Mencarelli A., Distrutti E., Renga B., D'Amore C., Cipriani S., Palladino G., Donini A., Ricci P., Fiorucci S. (2011). Probiotics modulate intestinal expression of nuclear receptor and provide Counter-Regulatory signals to Inflammation-Driven adipose tissue activation. PLoS ONE 6 (7) : e22978. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0022978Test; https://scholarbank.nus.edu.sg/handle/10635/162037Test

الإتاحة: https://doi.org/10.1371/journal.pone.0022978Test
https://scholarbank.nus.edu.sg/handle/10635/162037Test